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Protein

Transmembrane emp24 domain-containing protein 5

Gene

Tmed5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane emp24 domain-containing protein 5
Alternative name(s):
p24 family protein gamma-2
Short name:
p24gamma2
Gene namesi
Name:Tmed5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359437. Tmed5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 196169LumenalSequence analysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence analysisAdd
BLAST
Topological domaini218 – 22912CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 229202Transmembrane emp24 domain-containing protein 5PRO_0000010392Add
BLAST

Proteomic databases

PaxDbiQ6AXN3.
PRIDEiQ6AXN3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000000073.
GenevisibleiQ6AXN3. RN.

Interactioni

Subunit structurei

Interacts with TMED9 and TMED10.By similarity

Protein-protein interaction databases

MINTiMINT-4578345.
STRINGi10116.ENSRNOP00000000083.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 12682GOLDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the EMP24/GP25L family.Curated
Contains 1 GOLD domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3287. Eukaryota.
ENOG410Z18S. LUCA.
HOVERGENiHBG000271.
InParanoidiQ6AXN3.
KOiK14825.
OrthoDBiEOG091G0RNG.

Family and domain databases

InterProiIPR009038. GOLD_dom.
IPR015717. TMED5.
IPR015720. TMP21-related.
[Graphical view]
PANTHERiPTHR22811. PTHR22811. 1 hit.
PTHR22811:SF41. PTHR22811:SF41. 1 hit.
PfamiPF01105. EMP24_GP25L. 1 hit.
[Graphical view]
SMARTiSM01190. EMP24_GP25L. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
PROSITEiPS50866. GOLD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AXN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVRMWLPFP MLLLSALPAT LLSGAAGFTP SLDSDFTFTL PAGQKECFYQ
60 70 80 90 100
PMPLKASLEI EYQVLDGGEL DIDFHLASPE GRTLVFEQRK SDGVHTVETE
110 120 130 140 150
DGDYMFCFDN TFSTISEKVI FFELILDNMG EEVEGQEDWK KYITNTDVLE
160 170 180 190 200
MKLEDILESI NSIKSRLSKS GHIQTLLRAF EARDRNIQES NFDRVNFWSV
210 220
VNLMVMVVVS AIQVYTLKSL FEDKRKSRT
Length:229
Mass (Da):26,136
Last modified:September 13, 2004 - v1
Checksum:i2A2D8070B26F6C68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079452 mRNA. Translation: AAH79452.1.
RefSeqiNP_001007620.1. NM_001007619.1.
UniGeneiRn.204558.

Genome annotation databases

GeneIDi289883.
KEGGirno:289883.
UCSCiRGD:1359437. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079452 mRNA. Translation: AAH79452.1.
RefSeqiNP_001007620.1. NM_001007619.1.
UniGeneiRn.204558.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4578345.
STRINGi10116.ENSRNOP00000000083.

Proteomic databases

PaxDbiQ6AXN3.
PRIDEiQ6AXN3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi289883.
KEGGirno:289883.
UCSCiRGD:1359437. rat.

Organism-specific databases

CTDi50999.
RGDi1359437. Tmed5.

Phylogenomic databases

eggNOGiKOG3287. Eukaryota.
ENOG410Z18S. LUCA.
HOVERGENiHBG000271.
InParanoidiQ6AXN3.
KOiK14825.
OrthoDBiEOG091G0RNG.

Miscellaneous databases

PROiQ6AXN3.

Gene expression databases

BgeeiENSRNOG00000000073.
GenevisibleiQ6AXN3. RN.

Family and domain databases

InterProiIPR009038. GOLD_dom.
IPR015717. TMED5.
IPR015720. TMP21-related.
[Graphical view]
PANTHERiPTHR22811. PTHR22811. 1 hit.
PTHR22811:SF41. PTHR22811:SF41. 1 hit.
PfamiPF01105. EMP24_GP25L. 1 hit.
[Graphical view]
SMARTiSM01190. EMP24_GP25L. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
PROSITEiPS50866. GOLD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMED5_RAT
AccessioniPrimary (citable) accession number: Q6AXN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: September 13, 2004
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.