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Protein

Transmembrane emp24 domain-containing protein 5

Gene

Tmed5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane emp24 domain-containing protein 5
Alternative name(s):
p24 family protein gamma-2
Short name:
p24gamma2
Gene namesi
Name:Tmed5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359437. Tmed5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 196LumenalSequence analysisAdd BLAST169
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 229CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000001039228 – 229Transmembrane emp24 domain-containing protein 5Add BLAST202

Proteomic databases

PaxDbiQ6AXN3.
PRIDEiQ6AXN3.

Expressioni

Gene expression databases

GenevisibleiQ6AXN3. RN.

Interactioni

Subunit structurei

Interacts with TMED9 and TMED10.By similarity

Protein-protein interaction databases

MINTiMINT-4578345.
STRINGi10116.ENSRNOP00000000083.

Structurei

3D structure databases

SMRiQ6AXN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 126GOLDPROSITE-ProRule annotationAdd BLAST82

Sequence similaritiesi

Belongs to the EMP24/GP25L family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3287. Eukaryota.
ENOG410Z18S. LUCA.
HOVERGENiHBG000271.
InParanoidiQ6AXN3.
KOiK14825.
OrthoDBiEOG091G0RNG.

Family and domain databases

InterProiView protein in InterPro
IPR009038. GOLD_dom.
IPR036598. GOLD_dom_sf.
IPR015717. TMED5.
IPR015720. TMP21-related.
PANTHERiPTHR22811. PTHR22811. 1 hit.
PTHR22811:SF41. PTHR22811:SF41. 1 hit.
PfamiView protein in Pfam
PF01105. EMP24_GP25L. 1 hit.
SMARTiView protein in SMART
SM01190. EMP24_GP25L. 1 hit.
SUPFAMiSSF101576. SSF101576. 1 hit.
PROSITEiView protein in PROSITE
PS50866. GOLD. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AXN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVRMWLPFP MLLLSALPAT LLSGAAGFTP SLDSDFTFTL PAGQKECFYQ
60 70 80 90 100
PMPLKASLEI EYQVLDGGEL DIDFHLASPE GRTLVFEQRK SDGVHTVETE
110 120 130 140 150
DGDYMFCFDN TFSTISEKVI FFELILDNMG EEVEGQEDWK KYITNTDVLE
160 170 180 190 200
MKLEDILESI NSIKSRLSKS GHIQTLLRAF EARDRNIQES NFDRVNFWSV
210 220
VNLMVMVVVS AIQVYTLKSL FEDKRKSRT
Length:229
Mass (Da):26,136
Last modified:September 13, 2004 - v1
Checksum:i2A2D8070B26F6C68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079452 mRNA. Translation: AAH79452.1.
RefSeqiNP_001007620.1. NM_001007619.1.
UniGeneiRn.204558.

Genome annotation databases

GeneIDi289883.
KEGGirno:289883.
UCSCiRGD:1359437. rat.

Similar proteinsi

Entry informationi

Entry nameiTMED5_RAT
AccessioniPrimary (citable) accession number: Q6AXN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: September 13, 2004
Last modified: October 25, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families