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Protein
Submitted name:

EGF-containing fibulin-like extracellular matrix protein 1

Gene

Efemp1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-2129379. Molecules associated with elastic fibres.

Names & Taxonomyi

Protein namesi
Submitted name:
EGF-containing fibulin-like extracellular matrix protein 1Imported
Gene namesi
Name:Efemp1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1308528. Efemp1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_501084499518 – 493Sequence analysisAdd BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi218 ↔ 228PROSITE-ProRule annotation
Disulfide bondi258 ↔ 268PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000003553.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini173 – 213EGF-likeInterPro annotationAdd BLAST41
Domaini214 – 253EGF-likeInterPro annotationAdd BLAST40
Domaini254 – 293EGF-likeInterPro annotationAdd BLAST40
Domaini294 – 333EGF-likeInterPro annotationAdd BLAST40

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410KD9V. Eukaryota.
ENOG410YCRW. LUCA.
GeneTreeiENSGT00760000118806.
HOVERGENiHBG051560.
KOiK18262.
OMAiPCQDPYV.
OrthoDBiEOG091G04QP.

Family and domain databases

InterProiView protein in InterPro
IPR026823. cEGF.
IPR032973. EFEMP1.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
PANTHERiPTHR24044:SF369. PTHR24044:SF369. 1 hit.
PfamiView protein in Pfam
PF12662. cEGF. 2 hits.
PF07645. EGF_CA. 3 hits.
SMARTiView protein in SMART
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 6 hits.
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 4 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 2 hits.

Sequencei

Sequence statusi: Complete.

Q6AXN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQTVFLTML TLALVKSQVT EETITYTQCT DGYEWDPVRQ QCKDIDECDI
60 70 80 90 100
VPDACKGGMK CVNHYGGYLC LPKTAQIIVN NEQPQQETPA AEASSGAATG
110 120 130 140 150
TIAARSMATS GVIPGGGFIA SATAVAGPEV QTGRNNFVIR RNPADPQRIP
160 170 180 190 200
SNPSHRIQCA AGYEQSEHNV CQDIDECTSG THNCRLDQVC INLRGSFTCH
210 220 230 240 250
CLPGYQKRGE QCVDIDECSV PPYCHQGCVN TPGSFYCQCN PGFQLAANNY
260 270 280 290 300
TCVDINECDA SNQCAQQCYN ILGSFICQCN QGYELSSDRL NCEDIDECRT
310 320 330 340 350
SSYLCQYQCV NEPGKFSCMC PQGYQVVRSR TCQDINECET TNECREDEMC
360 370 380 390 400
WNYHGGFRCY PQNPCQDPYV LTSENRCVCP VSNTMCRDVP QSIVYKYMNI
410 420 430 440 450
RSDRSVPSDI FQIQATTIYA NTINTFRIKS GNENGEFYLR QTSPVSAMLV
460 470 480 490
LVKSLTGPRE HIVDLEMLTV SSIGTFRTSS VLRLTIIVGP FSF
Length:493
Mass (Da):54,654
Last modified:September 13, 2004 - v1
Checksum:i22DAFD70BACC2C96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07016732 Genomic DNA. No translation available.
AABR07016733 Genomic DNA. No translation available.
AABR07016734 Genomic DNA. No translation available.
AABR07016735 Genomic DNA. No translation available.
AABR07016736 Genomic DNA. No translation available.
BC079455 mRNA. Translation: AAH79455.1.
RefSeqiNP_001012039.1. NM_001012039.1.
XP_008768678.1. XM_008770456.2.
XP_008768679.1. XM_008770457.2.
UniGeneiRn.163265.

Genome annotation databases

EnsembliENSRNOT00000004764; ENSRNOP00000004764; ENSRNOG00000003553.
GeneIDi305604.
KEGGirno:305604.

Similar proteinsi

Entry informationi

Entry nameiQ6AXN2_RAT
AccessioniPrimary (citable) accession number: Q6AXN2
Secondary accession number(s): D4A080
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: September 27, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported