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Protein

Serum paraoxonase/arylesterase 2

Gene

Pon2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters.By similarity

Catalytic activityi

A phenyl acetate + H2O = a phenol + acetate.
An N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine.

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Calcium 1; catalyticBy similarity1
Metal bindingi54Calcium 2By similarity1
Active sitei114Proton acceptorBy similarity1
Metal bindingi116Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi167Calcium 1; catalyticBy similarity1
Metal bindingi168Calcium 2By similarity1
Metal bindingi223Calcium 1; catalyticBy similarity1
Metal bindingi268Calcium 1; catalyticBy similarity1
Metal bindingi269Calcium 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-2142688. Synthesis of 5-eicosatetraenoic acids.

Names & Taxonomyi

Protein namesi
Recommended name:
Serum paraoxonase/arylesterase 2 (EC:3.1.1.2, EC:3.1.1.81)
Short name:
PON 2
Alternative name(s):
Aromatic esterase 2
Short name:
A-esterase 2
Serum aryldialkylphosphatase 2
Gene namesi
Name:Pon2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1309954. Pon2.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: InterPro
  • intracellular membrane-bounded organelle Source: RGD
  • lysosome Source: RGD
  • mitochondrion Source: RGD
  • nucleus Source: RGD
  • plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002232891 – 354Serum paraoxonase/arylesterase 2Add BLAST354
Signal peptidei1 – ?Not cleavedSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 352By similarity
Glycosylationi254N-linked (GlcNAc...)Sequence analysis1
Glycosylationi269N-linked (GlcNAc...)Sequence analysis1
Glycosylationi323N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Glycosylated.By similarity
The signal sequence is not cleaved.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6AXM8.
PRIDEiQ6AXM8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000009112.
GenevisibleiQ6AXM8. RN.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033943.

Structurei

3D structure databases

ProteinModelPortaliQ6AXM8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paraoxonase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHDV. Eukaryota.
ENOG4111QK7. LUCA.
GeneTreeiENSGT00390000008932.
HOGENOMiHOG000252960.
HOVERGENiHBG003604.
InParanoidiQ6AXM8.
KOiK01045.
OMAiTWSNVVY.
OrthoDBiEOG091G0AV9.
PhylomeDBiQ6AXM8.
TreeFamiTF322436.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR002640. Arylesterase.
IPR008364. Paraoxonase2.
[Graphical view]
PfamiPF01731. Arylesterase. 1 hit.
[Graphical view]
PRINTSiPR01785. PARAOXONASE.
PR01787. PARAOXONASE2.

Sequencei

Sequence statusi: Complete.

Q6AXM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRLVALSLL GIGLALLGER FLALRSRLKA SREVESVDLP NCRLIKGIET
60 70 80 90 100
GAEDIDILPN GLAFFSVGLK FPGLHSFAPD KPGGILMMDL KEEKPRALEL
110 120 130 140 150
RVSWGFDLAS FNPHGISTFI DDDDTVYLFV VNHPEFKNTV EIFKFQEEEN
160 170 180 190 200
SLLHLKTIKH ELLPSVNDVI AVGPSHFYAT NDHYFSDPFL KYLETYLNLR
210 220 230 240 250
WANVVYYSPE EVKLVAEGFD SANGINISPD KKYVYVADIL AHEIHVLEKQ
260 270 280 290 300
PNMNLTQLKV LQLGTLVDNL SIDPSSGDIW VGCHPNGQKL FVYDPNHPPS
310 320 330 340 350
SEVLRIQNIL SEKPSVTTVY INNGSVLQGS SVATIYDRKL LVGTLYQRAL

YCEL
Length:354
Mass (Da):39,617
Last modified:September 13, 2004 - v1
Checksum:i69D77678C781859D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079462 mRNA. Translation: AAH79462.1.
RefSeqiNP_001013100.1. NM_001013082.1.
UniGeneiRn.1100.

Genome annotation databases

EnsembliENSRNOT00000036460; ENSRNOP00000033943; ENSRNOG00000009112.
GeneIDi296851.
KEGGirno:296851.
UCSCiRGD:1309954. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079462 mRNA. Translation: AAH79462.1.
RefSeqiNP_001013100.1. NM_001013082.1.
UniGeneiRn.1100.

3D structure databases

ProteinModelPortaliQ6AXM8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033943.

Proteomic databases

PaxDbiQ6AXM8.
PRIDEiQ6AXM8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000036460; ENSRNOP00000033943; ENSRNOG00000009112.
GeneIDi296851.
KEGGirno:296851.
UCSCiRGD:1309954. rat.

Organism-specific databases

CTDi5445.
RGDi1309954. Pon2.

Phylogenomic databases

eggNOGiENOG410IHDV. Eukaryota.
ENOG4111QK7. LUCA.
GeneTreeiENSGT00390000008932.
HOGENOMiHOG000252960.
HOVERGENiHBG003604.
InParanoidiQ6AXM8.
KOiK01045.
OMAiTWSNVVY.
OrthoDBiEOG091G0AV9.
PhylomeDBiQ6AXM8.
TreeFamiTF322436.

Enzyme and pathway databases

ReactomeiR-RNO-2142688. Synthesis of 5-eicosatetraenoic acids.

Miscellaneous databases

PROiQ6AXM8.

Gene expression databases

BgeeiENSRNOG00000009112.
GenevisibleiQ6AXM8. RN.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR002640. Arylesterase.
IPR008364. Paraoxonase2.
[Graphical view]
PfamiPF01731. Arylesterase. 1 hit.
[Graphical view]
PRINTSiPR01785. PARAOXONASE.
PR01787. PARAOXONASE2.
ProtoNetiSearch...

Entry informationi

Entry nameiPON2_RAT
AccessioniPrimary (citable) accession number: Q6AXM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: September 13, 2004
Last modified: November 30, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.