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Protein

HBS1-like protein

Gene

Hbs1l

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi262 – 269GTPBy similarity8
Nucleotide bindingi339 – 343GTPBy similarity5
Nucleotide bindingi401 – 404GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-429958. mRNA decay by 3' to 5' exoribonuclease.

Names & Taxonomyi

Protein namesi
Recommended name:
HBS1-like protein
Gene namesi
Name:Hbs1l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1308509. Hbs1l.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000914941 – 679HBS1-like proteinAdd BLAST679

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63PhosphoserineBy similarity1
Modified residuei113PhosphoserineBy similarity1
Modified residuei145PhosphoserineBy similarity1
Modified residuei147PhosphoserineCombined sources1
Modified residuei226PhosphothreonineBy similarity1
Modified residuei617N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6AXM7.
PRIDEiQ6AXM7.

PTM databases

iPTMnetiQ6AXM7.
PhosphoSitePlusiQ6AXM7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014531.
ExpressionAtlasiQ6AXM7. baseline and differential.
GenevisibleiQ6AXM7. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019734.

Structurei

3D structure databases

ProteinModelPortaliQ6AXM7.
SMRiQ6AXM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini253 – 477tr-type GPROSITE-ProRule annotationAdd BLAST225

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni262 – 269G1PROSITE-ProRule annotation8
Regioni318 – 322G2PROSITE-ProRule annotation5
Regioni339 – 342G3PROSITE-ProRule annotation4
Regioni401 – 404G4PROSITE-ProRule annotation4
Regioni440 – 442G5PROSITE-ProRule annotation3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0458. Eukaryota.
COG5256. LUCA.
GeneTreeiENSGT00620000087924.
HOGENOMiHOG000229291.
HOVERGENiHBG000179.
InParanoidiQ6AXM7.
KOiK14416.
OMAiHMIVIGH.
PhylomeDBiQ6AXM7.

Family and domain databases

InterProiView protein in InterPro
IPR015033. HBS1-like_N.
IPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004160. Transl_elong_EFTu/EF1A_C.
PfamiView protein in Pfam
PF00009. GTP_EFTU. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
PF08938. HBS1_N. 1 hit.
PRINTSiPR00315. ELONGATNFCT.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD278081. DUF1916. 1 hit.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51722. G_TR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AXM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARHRNVRGY NYDEDFEDDD LYGQSVEDDY CISPSTAAQF IYSRRDNPEE
60 70 80 90 100
EYGYEDLKES SNSLLNHQLS EIDQARLYSC LDHMREVLGD AVPDDILTEA
110 120 130 140 150
ILKHKFDVQK ALSVVLEQDG VQTLKEKSER AVCAGQPSKV ISRSSQSESE
160 170 180 190 200
IVPKVAKMTV SGKKQTMGFE VPGLPSEENG HNVRAPYKGP PGDDVSIASP
210 220 230 240 250
NVPETGTPKS TAHPPSLQTS EELGCTPTPL RKSGKLRQQI DVKAGLEKRQ
260 270 280 290 300
GGKQLLNLVV IGHVDAGKST LMGHMLYLLG NVNKRTMHKY EQESKKAGKA
310 320 330 340 350
SFAYAWVLDE TGEERERGVT MDVGMTKFET TTKVVTLMDA PGHKDFIPNM
360 370 380 390 400
ITGAAQADVA VLVVDASRGE FEAGFETGGQ TREHGLLVRS LGVTQLAVAV
410 420 430 440 450
NKMDQVNWQQ ERFQEITGKL GHFLKQAGFK ESDVAFIPTS GLSGENLTSR
460 470 480 490 500
SQSSDLTKWY KGLCLLEQID SFKPPQRSID KPFRLCVSDV FKDQGSGFCV
510 520 530 540 550
TGKIEAGYVQ TGDRLLAMPP NETCTAKGIT LHDEPVDWAA AGDHVSLTLV
560 570 580 590 600
GMDIIKINVG CIFCGPKEPI KACTRFRARI LIFNIEVPIT KGFPVLLHYQ
610 620 630 640 650
TVSEPAVIKR LISVLNKSTG EVTKKKPKLL TKGQNALVEL QTQRPVALEL
660 670
YKDFKELGRF MLRYGGSTVA AGVVTEIKE
Length:679
Mass (Da):74,774
Last modified:September 13, 2004 - v1
Checksum:i51D18EB5E8999A73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079463 mRNA. Translation: AAH79463.1.
RefSeqiNP_001011934.1. NM_001011934.1.
UniGeneiRn.98198.

Genome annotation databases

EnsembliENSRNOT00000019734; ENSRNOP00000019734; ENSRNOG00000014531.
GeneIDi293408.
KEGGirno:293408.

Similar proteinsi

Entry informationi

Entry nameiHBS1L_RAT
AccessioniPrimary (citable) accession number: Q6AXM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: September 13, 2004
Last modified: August 30, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families