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Protein

HBS1-like protein

Gene

Hbs1l

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi262 – 2698GTPBy similarity
Nucleotide bindingi339 – 3435GTPBy similarity
Nucleotide bindingi401 – 4044GTPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HBS1-like protein
Gene namesi
Name:Hbs1l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1308509. Hbs1l.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 679679HBS1-like proteinPRO_0000091494Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei113 – 1131PhosphoserineBy similarity
Modified residuei145 – 1451PhosphoserineBy similarity
Modified residuei147 – 1471PhosphoserineCombined sources
Modified residuei617 – 6171N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6AXM7.
PRIDEiQ6AXM7.

PTM databases

iPTMnetiQ6AXM7.
PhosphoSiteiQ6AXM7.

Expressioni

Gene expression databases

ExpressionAtlasiQ6AXM7. baseline and differential.
GenevisibleiQ6AXM7. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019734.

Structurei

3D structure databases

ProteinModelPortaliQ6AXM7.
SMRiQ6AXM7. Positions 56-120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini253 – 477225tr-type GPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni262 – 2698G1PROSITE-ProRule annotation
Regioni318 – 3225G2PROSITE-ProRule annotation
Regioni339 – 3424G3PROSITE-ProRule annotation
Regioni401 – 4044G4PROSITE-ProRule annotation
Regioni440 – 4423G5PROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family.PROSITE-ProRule annotation
Contains 1 tr-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0458. Eukaryota.
COG5256. LUCA.
GeneTreeiENSGT00620000087924.
HOGENOMiHOG000229291.
HOVERGENiHBG000179.
InParanoidiQ6AXM7.
KOiK14416.
PhylomeDBiQ6AXM7.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR015033. HBS1-like_N.
IPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF03143. GTP_EFTU_D3. 1 hit.
PF08938. HBS1_N. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
ProDomiPD278081. DUF1916. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AXM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARHRNVRGY NYDEDFEDDD LYGQSVEDDY CISPSTAAQF IYSRRDNPEE
60 70 80 90 100
EYGYEDLKES SNSLLNHQLS EIDQARLYSC LDHMREVLGD AVPDDILTEA
110 120 130 140 150
ILKHKFDVQK ALSVVLEQDG VQTLKEKSER AVCAGQPSKV ISRSSQSESE
160 170 180 190 200
IVPKVAKMTV SGKKQTMGFE VPGLPSEENG HNVRAPYKGP PGDDVSIASP
210 220 230 240 250
NVPETGTPKS TAHPPSLQTS EELGCTPTPL RKSGKLRQQI DVKAGLEKRQ
260 270 280 290 300
GGKQLLNLVV IGHVDAGKST LMGHMLYLLG NVNKRTMHKY EQESKKAGKA
310 320 330 340 350
SFAYAWVLDE TGEERERGVT MDVGMTKFET TTKVVTLMDA PGHKDFIPNM
360 370 380 390 400
ITGAAQADVA VLVVDASRGE FEAGFETGGQ TREHGLLVRS LGVTQLAVAV
410 420 430 440 450
NKMDQVNWQQ ERFQEITGKL GHFLKQAGFK ESDVAFIPTS GLSGENLTSR
460 470 480 490 500
SQSSDLTKWY KGLCLLEQID SFKPPQRSID KPFRLCVSDV FKDQGSGFCV
510 520 530 540 550
TGKIEAGYVQ TGDRLLAMPP NETCTAKGIT LHDEPVDWAA AGDHVSLTLV
560 570 580 590 600
GMDIIKINVG CIFCGPKEPI KACTRFRARI LIFNIEVPIT KGFPVLLHYQ
610 620 630 640 650
TVSEPAVIKR LISVLNKSTG EVTKKKPKLL TKGQNALVEL QTQRPVALEL
660 670
YKDFKELGRF MLRYGGSTVA AGVVTEIKE
Length:679
Mass (Da):74,774
Last modified:September 13, 2004 - v1
Checksum:i51D18EB5E8999A73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079463 mRNA. Translation: AAH79463.1.
RefSeqiNP_001011934.1. NM_001011934.1.
UniGeneiRn.98198.

Genome annotation databases

EnsembliENSRNOT00000019734; ENSRNOP00000019734; ENSRNOG00000014531.
GeneIDi293408.
KEGGirno:293408.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079463 mRNA. Translation: AAH79463.1.
RefSeqiNP_001011934.1. NM_001011934.1.
UniGeneiRn.98198.

3D structure databases

ProteinModelPortaliQ6AXM7.
SMRiQ6AXM7. Positions 56-120.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019734.

PTM databases

iPTMnetiQ6AXM7.
PhosphoSiteiQ6AXM7.

Proteomic databases

PaxDbiQ6AXM7.
PRIDEiQ6AXM7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019734; ENSRNOP00000019734; ENSRNOG00000014531.
GeneIDi293408.
KEGGirno:293408.

Organism-specific databases

CTDi10767.
RGDi1308509. Hbs1l.

Phylogenomic databases

eggNOGiKOG0458. Eukaryota.
COG5256. LUCA.
GeneTreeiENSGT00620000087924.
HOGENOMiHOG000229291.
HOVERGENiHBG000179.
InParanoidiQ6AXM7.
KOiK14416.
PhylomeDBiQ6AXM7.

Miscellaneous databases

NextBioi636041.
PROiQ6AXM7.

Gene expression databases

ExpressionAtlasiQ6AXM7. baseline and differential.
GenevisibleiQ6AXM7. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR015033. HBS1-like_N.
IPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF03143. GTP_EFTU_D3. 1 hit.
PF08938. HBS1_N. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
ProDomiPD278081. DUF1916. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-147, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHBS1L_RAT
AccessioniPrimary (citable) accession number: Q6AXM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: September 13, 2004
Last modified: May 11, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.