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Protein

Cyclin-dependent kinase-like 1

Gene

cdkl1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei126Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • protein phosphorylation Source: ZFIN

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 1By similarity (EC:2.7.11.22)
Gene namesi
Name:cdkl1By similarity
ORF Names:zgc:101002
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040808-34 cdkl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000858131 – 350Cyclin-dependent kinase-like 1Add BLAST350

Proteomic databases

PaxDbiQ6AXJ9
PRIDEiQ6AXJ9

Structurei

3D structure databases

ProteinModelPortaliQ6AXJ9
SMRiQ6AXJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 287Protein kinasePROSITE-ProRule annotationAdd BLAST284

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 51[NKR]KIAxRE7

Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0593 Eukaryota
ENOG410XNSW LUCA
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiQ6AXJ9
KOiK08824
PhylomeDBiQ6AXJ9

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q6AXJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKYEKISKI GEGSYGVVFK CRNKDTGQIV AIKKFVESED DPIIKKIALR
60 70 80 90 100
EIRMLKQLKH PNLVNLMEVF RRKRKLHLVF EYCDHTVLNE LDRYPRGVPE
110 120 130 140 150
HMVKSIIWQT LQAVNFCHKQ NCIHRDVKPE NILITKHQVI KLCDFGFARI
160 170 180 190 200
LTGPCDYYTD CVATRWYRAP ELLVGDTQYG PPVDVWAVGC VFAELLSGAP
210 220 230 240 250
LWPGKSDVDQ LYLIRKTLGE LIPRHQQVFS TNQFFSGVCV PEPQEMEPLE
260 270 280 290 300
LKYPNLSYQA LSLMKGCLRM DPAERLSCEQ LLEQPYFDSL REESESVTRE
310 320 330 340 350
LDRKKRTRQP RKHLPPGYLP QLASSTVFPA VENRRNYNNL RKFNYHLPNI
Length:350
Mass (Da):40,810
Last modified:September 13, 2004 - v1
Checksum:i9B04440EE0E38BE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079506 mRNA Translation: AAH79506.1
RefSeqiNP_001003773.1, NM_001003773.1
UniGeneiDr.106937

Genome annotation databases

GeneIDi445316
KEGGidre:445316

Similar proteinsi

Entry informationi

Entry nameiCDKL1_DANRE
AccessioniPrimary (citable) accession number: Q6AXJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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