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Q6AXJ9 (CDKL1_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase-like 1

EC=2.7.11.22
Gene names
Name:cdkl1
ORF Names:zgc:101002
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Domain

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Cyclin-dependent kinase-like 1
PRO_0000085813

Regions

Domain4 – 287284Protein kinase
Nucleotide binding10 – 189ATP By similarity
Motif45 – 517[NKR]KIAxRE

Sites

Active site1261Proton acceptor By similarity
Binding site331ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AXJ9 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 9B04440EE0E38BE1

FASTA35040,810
        10         20         30         40         50         60 
MEKYEKISKI GEGSYGVVFK CRNKDTGQIV AIKKFVESED DPIIKKIALR EIRMLKQLKH 

        70         80         90        100        110        120 
PNLVNLMEVF RRKRKLHLVF EYCDHTVLNE LDRYPRGVPE HMVKSIIWQT LQAVNFCHKQ 

       130        140        150        160        170        180 
NCIHRDVKPE NILITKHQVI KLCDFGFARI LTGPCDYYTD CVATRWYRAP ELLVGDTQYG 

       190        200        210        220        230        240 
PPVDVWAVGC VFAELLSGAP LWPGKSDVDQ LYLIRKTLGE LIPRHQQVFS TNQFFSGVCV 

       250        260        270        280        290        300 
PEPQEMEPLE LKYPNLSYQA LSLMKGCLRM DPAERLSCEQ LLEQPYFDSL REESESVTRE 

       310        320        330        340        350 
LDRKKRTRQP RKHLPPGYLP QLASSTVFPA VENRRNYNNL RKFNYHLPNI 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC079506 mRNA. Translation: AAH79506.1.
RefSeqNP_001003773.1. NM_001003773.1.
UniGeneDr.106937.

3D structure databases

ProteinModelPortalQ6AXJ9.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID445316.
KEGGdre:445316.

Organism-specific databases

CTD8814.
ZFINZDB-GENE-040808-34. cdkl1.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
HOVERGENHBG014652.
InParanoidQ6AXJ9.
KOK08824.
PhylomeDBQ6AXJ9.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20832059.
PROQ6AXJ9.

Entry information

Entry nameCDKL1_DANRE
AccessionPrimary (citable) accession number: Q6AXJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: September 13, 2004
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families