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Protein
Submitted name:

Ezh2 protein

Gene

Ezh2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Ezh2 proteinImported
Submitted name:
Histone-lysine N-methyltransferase EZH2Imported
Gene namesi
Name:Ezh2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107940. Ezh2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080419.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini499 – 601103CXCInterPro annotationAdd
BLAST
Domaini608 – 723116SETInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG1079. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00760000119228.
HOGENOMiHOG000008176.
HOVERGENiHBG002453.
KOiK11430.

Family and domain databases

InterProiIPR026489. CXC_dom.
IPR021654. EZH1/EZH2.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
IPR033467. Tesmin/TSO1-like_CXC.
[Graphical view]
PfamiPF11616. EZH2_WD-Binding. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM01114. CXC. 1 hit.
SM00717. SANT. 2 hits.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51633. CXC. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AXH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQTGKKSEK GPVCWRKRVK SEYMRLRQLK RFRRADEVKT MFSSNRQKIL
60 70 80 90 100
ERTETLNQEW KQRRIQPVHI MTSCSVTSDL DFPAQVIPLK TLNAVASVPI
110 120 130 140 150
MYSWSPLQQN FMVEDETVLH NIPYMGDEVL DQDGTFIEEL IKNYDGKVHG
160 170 180 190 200
DRECGFINDE IFVELVNALG QYNDDDDDDD GDDPDEREEK QKDLEDNRDD
210 220 230 240 250
KETCPPRKFP ADKIFEAISS MFPDKGTAEE LKEKYKELTE QQLPGALPPE
260 270 280 290 300
CTPNIDGPNA KSVQREQSLH SFHTLFCRRC FKYDCFLHRK CSYSFHATPN
310 320 330 340 350
TYKRKNTETA LDNKPCGPQC YQHLEGAKEF AAALTAERIK TPPKRPGGRR
360 370 380 390 400
RGRLPNNSSR PSTPTISVLE SKDTDSDREA GTETGGENND KEEEEKKDET
410 420 430 440 450
SSSSEANSRC QTPIKMKPNI EPPENVEWSG AEASMFRVLI GTYYDNFCAI
460 470 480 490 500
ARLIGTKTCR QVYEFRVKES SIIAPVPTED VDTPPRKKKR KHRLWAAHCR
510 520 530 540 550
KIQLKKDGSS NHVYNYQPCD HPRQPCDSSC PCVIAQNFCE KFCQCSSECQ
560 570 580 590 600
NRFPGCRCKA QCNTKQCPCY LAVRECDPDL CLTCGAADHW DSKNVSCKNC
610 620 630 640 650
SIQRGSKKHL LLAPSDVAGW GIFIKDPVQK NEFISEYCGE IISQDEADRR
660 670 680 690 700
GKVYDKYMCS FLFNLNNDFV VDATRKGNKI RFANHSVNPN CYAKVMMVNG
710 720 730 740
DHRIGIFAKR AIQTGEELFF DYRYSQADAL KYVGIEREME IP
Length:742
Mass (Da):84,934
Last modified:September 13, 2004 - v1
Checksum:iA9CDB80ACB2C6D6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154015 Genomic DNA. No translation available.
AC155652 Genomic DNA. No translation available.
BC079538 mRNA. Translation: AAH79538.1.
RefSeqiNP_001140161.1. NM_001146689.1.
NP_031997.2. NM_007971.2.
UniGeneiMm.246688.

Genome annotation databases

EnsembliENSMUST00000114618; ENSMUSP00000110265; ENSMUSG00000029687.
GeneIDi14056.
KEGGimmu:14056.
UCSCiuc009btc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154015 Genomic DNA. No translation available.
AC155652 Genomic DNA. No translation available.
BC079538 mRNA. Translation: AAH79538.1.
RefSeqiNP_001140161.1. NM_001146689.1.
NP_031997.2. NM_007971.2.
UniGeneiMm.246688.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080419.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114618; ENSMUSP00000110265; ENSMUSG00000029687.
GeneIDi14056.
KEGGimmu:14056.
UCSCiuc009btc.2. mouse.

Organism-specific databases

CTDi2146.
MGIiMGI:107940. Ezh2.

Phylogenomic databases

eggNOGiKOG1079. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00760000119228.
HOGENOMiHOG000008176.
HOVERGENiHBG002453.
KOiK11430.

Miscellaneous databases

ChiTaRSiEzh2. mouse.
NextBioi285012.
SOURCEiSearch...

Family and domain databases

InterProiIPR026489. CXC_dom.
IPR021654. EZH1/EZH2.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
IPR033467. Tesmin/TSO1-like_CXC.
[Graphical view]
PfamiPF11616. EZH2_WD-Binding. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM01114. CXC. 1 hit.
SM00717. SANT. 2 hits.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51633. CXC. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ6AXH7_MOUSE
AccessioniPrimary (citable) accession number: Q6AXH7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: May 11, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.