ID Q6AXB7_MOUSE Unreviewed; 614 AA. AC Q6AXB7; DT 13-SEP-2004, integrated into UniProtKB/TrEMBL. DT 13-SEP-2004, sequence version 1. DT 27-MAR-2024, entry version 140. DE SubName: Full=Fragile X mental retardation syndrome 1 homolog {ECO:0000313|EMBL:AAH79671.1}; DE SubName: Full=Fragile X messenger ribonucleoprotein 1 {ECO:0000313|Ensembl:ENSMUSP00000085906.6}; GN Name=Fmr1 {ECO:0000313|EMBL:AAH79671.1, GN ECO:0000313|Ensembl:ENSMUSP00000085906.6, ECO:0000313|MGI:MGI:95564}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH79671.1}; RN [1] {ECO:0000313|EMBL:AAH79671.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAH79671.1}; RC TISSUE=Brain {ECO:0000313|EMBL:AAH79671.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000085906.6, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000085906.6, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [4] {ECO:0007829|PubMed:24129315} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24129315; RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M., RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V., RA Bedford M.T., Comb M.J.; RT "Immunoaffinity enrichment and mass spectrometry analysis of protein RT methylation."; RL Mol. Cell. Proteomics 13:372-387(2014). RN [5] {ECO:0000313|Ensembl:ENSMUSP00000085906.6} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000085906.6}; RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. CC Cell projection, axon {ECO:0000256|ARBA:ARBA00004489}. Cell projection, CC dendrite {ECO:0000256|ARBA:ARBA00004279}. Cell projection, dendritic CC spine {ECO:0000256|ARBA:ARBA00004552}. Cell projection, filopodium tip CC {ECO:0000256|ARBA:ARBA00004495}. Cell projection, growth cone CC {ECO:0000256|ARBA:ARBA00004624}. Cell projection, neuron projection CC {ECO:0000256|ARBA:ARBA00004487}. Chromosome, centromere CC {ECO:0000256|ARBA:ARBA00004584}. Cytoplasm, Cytoplasmic CC ribonucleoprotein granule {ECO:0000256|ARBA:ARBA00004331}. Cytoplasm, CC Stress granule {ECO:0000256|ARBA:ARBA00004210}. Cytoplasm, perinuclear CC region {ECO:0000256|ARBA:ARBA00004556}. Membrane CC {ECO:0000256|ARBA:ARBA00004370}. Nucleus, nucleolus CC {ECO:0000256|ARBA:ARBA00004604}. Perikaryon CC {ECO:0000256|ARBA:ARBA00004484}. Presynaptic cell membrane CC {ECO:0000256|ARBA:ARBA00034111}. Synapse, synaptosome CC {ECO:0000256|ARBA:ARBA00034102}. Synaptic cell membrane CC {ECO:0000256|ARBA:ARBA00034109}. CC -!- SIMILARITY: Belongs to the FMR1 family. CC {ECO:0000256|ARBA:ARBA00006633}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC079671; AAH79671.1; -; mRNA. DR RefSeq; NP_001277353.1; NM_001290424.1. DR RefSeq; NP_032057.2; NM_008031.3. DR ProteomicsDB; 337214; -. DR Antibodypedia; 3246; 834 antibodies from 45 providers. DR DNASU; 14265; -. DR Ensembl; ENSMUST00000088546.12; ENSMUSP00000085906.6; ENSMUSG00000000838.18. DR GeneID; 14265; -. DR KEGG; mmu:14265; -. DR UCSC; uc009tiw.2; mouse. DR AGR; MGI:95564; -. DR CTD; 2332; -. DR MGI; MGI:95564; Fmr1. DR VEuPathDB; HostDB:ENSMUSG00000000838; -. DR GeneTree; ENSGT00950000183189; -. DR OrthoDB; 2995592at2759; -. DR TreeFam; TF105427; -. DR BioGRID-ORCS; 14265; 4 hits in 63 CRISPR screens. DR ChiTaRS; Fmr1; mouse. DR Proteomes; UP000000589; Chromosome X. DR Bgee; ENSMUSG00000000838; Expressed in humerus cartilage element and 262 other cell types or tissues. DR GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell. DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:UniProtKB-SubCell. DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell. DR GO; GO:0032433; C:filopodium tip; IEA:UniProtKB-SubCell. DR GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell. DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell. DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW. DR GO; GO:0003729; F:mRNA binding; IEA:InterPro. DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW. DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW. DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. DR CDD; cd22506; KH_I_FMR1_rpt1; 1. DR CDD; cd22509; KH_I_FMR1_rpt2; 1. DR CDD; cd20471; Tudor_Agenet_FMR1_rpt1; 1. DR CDD; cd20474; Tudor_Agenet_FMR1_rpt2; 1. DR Gene3D; 2.30.30.140; -; 2. DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 3. DR InterPro; IPR008395; Agenet-like_dom. DR InterPro; IPR040148; FMR1. DR InterPro; IPR022034; FMR1-like_C_core. DR InterPro; IPR032196; FMR1_C2. DR InterPro; IPR040472; FMRP_KH0. DR InterPro; IPR004087; KH_dom. DR InterPro; IPR004088; KH_dom_type_1. DR InterPro; IPR036612; KH_dom_type_1_sf. DR InterPro; IPR047438; KH_I_FMR1_rpt1. DR InterPro; IPR047440; KH_I_FMR1_rpt2. DR InterPro; IPR047431; Tudor_Agenet_FMR1_rpt1. DR InterPro; IPR047436; Tudor_Agenet_FMR1_rpt2. DR InterPro; IPR041560; Tudor_FRM1. DR PANTHER; PTHR10603; FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN; 1. DR PANTHER; PTHR10603:SF4; SYNAPTIC FUNCTIONAL REGULATOR FMR1; 1. DR Pfam; PF05641; Agenet; 1. DR Pfam; PF16098; FXMR_C2; 2. DR Pfam; PF12235; FXMRP1_C_core; 1. DR Pfam; PF00013; KH_1; 2. DR Pfam; PF17904; KH_9; 1. DR Pfam; PF18336; Tudor_FRX1; 1. DR SMART; SM00322; KH; 2. DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2. DR PROSITE; PS51641; AGENET_LIKE; 2. DR PROSITE; PS50084; KH_TYPE_1; 2. PE 1: Evidence at protein level; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Cell projection {ECO:0000256|ARBA:ARBA00023273}; KW Centromere {ECO:0000256|ARBA:ARBA00023328}; KW Chromosome {ECO:0000256|ARBA:ARBA00022454}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW mRNA processing {ECO:0000256|ARBA:ARBA00022664}; KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187}; KW mRNA transport {ECO:0000256|ARBA:ARBA00022816}; KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Proteomics identification {ECO:0007829|EPD:Q6AXB7, KW ECO:0007829|MaxQB:Q6AXB7}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Repressor {ECO:0000256|ARBA:ARBA00022491}; KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274}; KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE- KW ProRule:PRU00117}; Synapse {ECO:0000256|ARBA:ARBA00023018}; KW Synaptosome {ECO:0000256|ARBA:ARBA00022599}; KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}; KW Transport {ECO:0000256|ARBA:ARBA00022448}. FT DOMAIN 4..50 FT /note="Agenet-like" FT /evidence="ECO:0000259|PROSITE:PS51641" FT DOMAIN 63..115 FT /note="Agenet-like" FT /evidence="ECO:0000259|PROSITE:PS51641" FT REGION 323..369 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 442..614 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 499..536 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 548..570 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 586..603 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 614 AA; 68890 MW; 122768A6422F6066 CRC64; MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPER QIPFHDVRFP PPVGYNKDIN ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP ATKDTFHKIK LEVPEDLRQM CAKESAHKDF KKAVGAFSVT YDPENYQLVI LSINEVTSKR AHMLIDMHFR SLRTKLSLIL RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN IQQARKVPGV TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN GKLIQEIVDK SGVVRVRIEA ENEKSVPQEE EIMPPSSLPS NNSRVGPNSS EEKKHLDTKE NTHFSQPNST KVQRVLVVSS IVAGGPQKPE PKAWQGMVPF VFVGTKDSIA NATVLLDYHL NYLKEVDQLR LERLQIDEQL RQIGASSRPP PNRTDKEKGY VTDDGQGMGR GSRPYRNRGH GRRGPGYTSG TNSEASNASE TESDHRDELS DWSLAPTEEE RESFLRRGDG RRRGGGGRGQ GGRGRGGGFK GNDDHSRTDN RPRNPREAKG RTADGSLQSA SSEGSRLRTG KDRNQKKEKP DSVDGLQPLV NGVP //