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Q6AXB7

- Q6AXB7_MOUSE

UniProt

Q6AXB7 - Q6AXB7_MOUSE

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Protein
Submitted name:

Fragile X mental retardation protein 1 homolog

Gene

Fmr1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. microtubule binding Source: MGI
  2. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. central nervous system development Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Fragile X mental retardation protein 1 homologImported
Submitted name:
Fragile X mental retardation syndrome 1 homologImported
Gene namesi
Name:Fmr1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:95564. Fmr1.

Subcellular locationi

GO - Cellular componenti

  1. cell body Source: MGI
  2. cytoplasmic stress granule Source: MGI
  3. dendritic shaft Source: Ensembl
  4. dendritic spine Source: Ensembl
  5. membrane Source: Ensembl
  6. microtubule Source: Ensembl
  7. neuronal ribonucleoprotein granule Source: MGI
  8. nucleus Source: MGI
  9. polysome Source: Ensembl
  10. synapse Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ6AXB7.

Family & Domainsi

Sequence similaritiesi

Contains 2 KH domains.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000017033.
HOVERGENiHBG005739.
KOiK15516.
OrthoDBiEOG7NKKJT.
TreeFamiTF105427.

Family and domain databases

Gene3Di3.30.1370.10. 3 hits.
InterProiIPR008395. Agenet-like_dom.
IPR022034. Frag_X_MRP_fam.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF05641. Agenet. 1 hit.
PF12235. FXR1P_C. 1 hit.
PF00013. KH_1. 2 hits.
[Graphical view]
SMARTiSM00322. KH. 2 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 2 hits.
PROSITEiPS51641. AGENET_LIKE. 2 hits.
PS50084. KH_TYPE_1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AXB7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPER QIPFHDVRFP
60 70 80 90 100
PPVGYNKDIN ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD
110 120 130 140 150
ATYNEIVTIE RLRSVNPNKP ATKDTFHKIK LEVPEDLRQM CAKESAHKDF
160 170 180 190 200
KKAVGAFSVT YDPENYQLVI LSINEVTSKR AHMLIDMHFR SLRTKLSLIL
210 220 230 240 250
RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN IQQARKVPGV
260 270 280 290 300
TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN
310 320 330 340 350
GKLIQEIVDK SGVVRVRIEA ENEKSVPQEE EIMPPSSLPS NNSRVGPNSS
360 370 380 390 400
EEKKHLDTKE NTHFSQPNST KVQRVLVVSS IVAGGPQKPE PKAWQGMVPF
410 420 430 440 450
VFVGTKDSIA NATVLLDYHL NYLKEVDQLR LERLQIDEQL RQIGASSRPP
460 470 480 490 500
PNRTDKEKGY VTDDGQGMGR GSRPYRNRGH GRRGPGYTSG TNSEASNASE
510 520 530 540 550
TESDHRDELS DWSLAPTEEE RESFLRRGDG RRRGGGGRGQ GGRGRGGGFK
560 570 580 590 600
GNDDHSRTDN RPRNPREAKG RTADGSLQSA SSEGSRLRTG KDRNQKKEKP
610
DSVDGLQPLV NGVP
Length:614
Mass (Da):68,890
Last modified:September 13, 2004 - v1
Checksum:i122768A6422F6066
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC055766 Genomic DNA. No translation available.
BC079671 mRNA. Translation: AAH79671.1.
RefSeqiNP_001277353.1. NM_001290424.1.
NP_032057.2. NM_008031.3.
UniGeneiMm.3451.

Genome annotation databases

EnsembliENSMUST00000088546; ENSMUSP00000085906; ENSMUSG00000000838.
GeneIDi14265.
KEGGimmu:14265.
UCSCiuc009tiw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC055766 Genomic DNA. No translation available.
BC079671 mRNA. Translation: AAH79671.1 .
RefSeqi NP_001277353.1. NM_001290424.1.
NP_032057.2. NM_008031.3.
UniGenei Mm.3451.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000088546 ; ENSMUSP00000085906 ; ENSMUSG00000000838 .
GeneIDi 14265.
KEGGi mmu:14265.
UCSCi uc009tiw.1. mouse.

Organism-specific databases

CTDi 2332.
MGIi MGI:95564. Fmr1.

Phylogenomic databases

GeneTreei ENSGT00390000017033.
HOVERGENi HBG005739.
KOi K15516.
OrthoDBi EOG7NKKJT.
TreeFami TF105427.

Miscellaneous databases

ChiTaRSi Fmr1. mouse.
NextBioi 285619.
SOURCEi Search...

Gene expression databases

Genevestigatori Q6AXB7.

Family and domain databases

Gene3Di 3.30.1370.10. 3 hits.
InterProi IPR008395. Agenet-like_dom.
IPR022034. Frag_X_MRP_fam.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view ]
Pfami PF05641. Agenet. 1 hit.
PF12235. FXR1P_C. 1 hit.
PF00013. KH_1. 2 hits.
[Graphical view ]
SMARTi SM00322. KH. 2 hits.
[Graphical view ]
SUPFAMi SSF54791. SSF54791. 2 hits.
PROSITEi PS51641. AGENET_LIKE. 2 hits.
PS50084. KH_TYPE_1. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ6AXB7_MOUSE
AccessioniPrimary (citable) accession number: Q6AXB7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: November 26, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3