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Q6AXB7

- Q6AXB7_MOUSE

UniProt

Q6AXB7 - Q6AXB7_MOUSE

Protein
Submitted name:

Fragile X mental retardation protein 1 homolog

Gene

Fmr1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. microtubule binding Source: MGI
    2. protein binding Source: MGI
    3. RNA binding Source: Ensembl

    GO - Biological processi

    1. central nervous system development Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Fragile X mental retardation protein 1 homologImported
    Submitted name:
    Fragile X mental retardation syndrome 1 homologImported
    Gene namesi
    Name:Fmr1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:95564. Fmr1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell body Source: MGI
    2. cytoplasmic stress granule Source: MGI
    3. dendritic shaft Source: Ensembl
    4. dendritic spine Source: Ensembl
    5. neuronal ribonucleoprotein granule Source: MGI
    6. nucleus Source: MGI
    7. synapse Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriQ6AXB7.

    Family & Domainsi

    Sequence similaritiesi

    Contains 2 KH domains.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000017033.
    HOVERGENiHBG005739.
    KOiK15516.
    OrthoDBiEOG7NKKJT.
    TreeFamiTF105427.

    Family and domain databases

    Gene3Di3.30.1370.10. 3 hits.
    InterProiIPR008395. Agenet-like_dom.
    IPR022034. Frag_X_MRP_fam.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    [Graphical view]
    PfamiPF05641. Agenet. 1 hit.
    PF12235. FXR1P_C. 1 hit.
    PF00013. KH_1. 2 hits.
    [Graphical view]
    SMARTiSM00322. KH. 2 hits.
    [Graphical view]
    SUPFAMiSSF54791. SSF54791. 2 hits.
    PROSITEiPS51641. AGENET_LIKE. 2 hits.
    PS50084. KH_TYPE_1. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6AXB7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPER QIPFHDVRFP    50
    PPVGYNKDIN ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD 100
    ATYNEIVTIE RLRSVNPNKP ATKDTFHKIK LEVPEDLRQM CAKESAHKDF 150
    KKAVGAFSVT YDPENYQLVI LSINEVTSKR AHMLIDMHFR SLRTKLSLIL 200
    RNEEASKQLE SSRQLASRFH EQFIVREDLM GLAIGTHGAN IQQARKVPGV 250
    TAIDLDEDTC TFHIYGEDQD AVKKARSFLE FAEDVIQVPR NLVGKVIGKN 300
    GKLIQEIVDK SGVVRVRIEA ENEKSVPQEE EIMPPSSLPS NNSRVGPNSS 350
    EEKKHLDTKE NTHFSQPNST KVQRVLVVSS IVAGGPQKPE PKAWQGMVPF 400
    VFVGTKDSIA NATVLLDYHL NYLKEVDQLR LERLQIDEQL RQIGASSRPP 450
    PNRTDKEKGY VTDDGQGMGR GSRPYRNRGH GRRGPGYTSG TNSEASNASE 500
    TESDHRDELS DWSLAPTEEE RESFLRRGDG RRRGGGGRGQ GGRGRGGGFK 550
    GNDDHSRTDN RPRNPREAKG RTADGSLQSA SSEGSRLRTG KDRNQKKEKP 600
    DSVDGLQPLV NGVP 614
    Length:614
    Mass (Da):68,890
    Last modified:September 13, 2004 - v1
    Checksum:i122768A6422F6066
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC055766 Genomic DNA. No translation available.
    BC079671 mRNA. Translation: AAH79671.1.
    RefSeqiNP_001277353.1. NM_001290424.1.
    NP_032057.2. NM_008031.3.
    UniGeneiMm.3451.

    Genome annotation databases

    EnsembliENSMUST00000088546; ENSMUSP00000085906; ENSMUSG00000000838.
    GeneIDi14265.
    KEGGimmu:14265.
    UCSCiuc009tiw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC055766 Genomic DNA. No translation available.
    BC079671 mRNA. Translation: AAH79671.1 .
    RefSeqi NP_001277353.1. NM_001290424.1.
    NP_032057.2. NM_008031.3.
    UniGenei Mm.3451.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000088546 ; ENSMUSP00000085906 ; ENSMUSG00000000838 .
    GeneIDi 14265.
    KEGGi mmu:14265.
    UCSCi uc009tiw.1. mouse.

    Organism-specific databases

    CTDi 2332.
    MGIi MGI:95564. Fmr1.

    Phylogenomic databases

    GeneTreei ENSGT00390000017033.
    HOVERGENi HBG005739.
    KOi K15516.
    OrthoDBi EOG7NKKJT.
    TreeFami TF105427.

    Miscellaneous databases

    ChiTaRSi FMR1. mouse.
    NextBioi 285619.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q6AXB7.

    Family and domain databases

    Gene3Di 3.30.1370.10. 3 hits.
    InterProi IPR008395. Agenet-like_dom.
    IPR022034. Frag_X_MRP_fam.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    [Graphical view ]
    Pfami PF05641. Agenet. 1 hit.
    PF12235. FXR1P_C. 1 hit.
    PF00013. KH_1. 2 hits.
    [Graphical view ]
    SMARTi SM00322. KH. 2 hits.
    [Graphical view ]
    SUPFAMi SSF54791. SSF54791. 2 hits.
    PROSITEi PS51641. AGENET_LIKE. 2 hits.
    PS50084. KH_TYPE_1. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6Imported.
      Tissue: BrainImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ6AXB7_MOUSE
    AccessioniPrimary (citable) accession number: Q6AXB7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 13, 2004
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3