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Q6AX23

- QSOX2_XENLA

UniProt

Q6AX23 - QSOX2_XENLA

Protein

Sulfhydryl oxidase 2

Gene

qsox2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins By similarity.By similarity

    Catalytic activityi

    2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

    Cofactori

    Binds 1 FAD per subunit.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei67 – 671NucleophileBy similarity
    Active sitei70 – 701NucleophileBy similarity
    Binding sitei405 – 4051FADBy similarity
    Binding sitei412 – 4121FADBy similarity
    Binding sitei416 – 4161FADBy similarity
    Binding sitei457 – 4571FADBy similarity
    Binding sitei461 – 4611FADBy similarity
    Binding sitei506 – 5061FADBy similarity
    Binding sitei509 – 5091FADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi484 – 4918FADBy similarity

    GO - Molecular functioni

    1. thiol oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sulfhydryl oxidase 2 (EC:1.8.3.2)
    Alternative name(s):
    Quiescin Q6-like protein 1
    Gene namesi
    Name:qsox2
    Synonyms:qscn6l1
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-986401. qsox2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 661632Sulfhydryl oxidase 2PRO_0000249540Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi67 ↔ 70Redox-activePROSITE-ProRule annotation
    Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi397 ↔ 409PROSITE-ProRule annotation
    Disulfide bondi455 ↔ 458PROSITE-ProRule annotation
    Disulfide bondi515 ↔ 518PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AX23.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei625 – 64521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 155126ThioredoxinPROSITE-ProRule annotationAdd
    BLAST
    Domaini400 – 509110ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi642 – 6476Poly-Phe

    Sequence similaritiesi

    Contains 1 ERV/ALR sulfhydryl oxidase domain.PROSITE-ProRule annotation
    Contains 1 thioredoxin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG080360.
    KOiK10758.

    Family and domain databases

    Gene3Di1.20.120.310. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
    IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF04777. Evr1_Alr. 1 hit.
    PF00085. Thioredoxin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    SSF69000. SSF69000. 1 hit.
    PROSITEiPS51324. ERV_ALR. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6AX23-1 [UniParc]FASTAAdd to Basket

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    MAAFVGLPLR SVPMLLLLLL LVVAGTARGE TLYGPEDSVT ILNKESVARA    50
    VFNSSSAWLL EFYSSWCGHC INYAPTWKAL ARDVRDWEPA IKIGVLDCAE 100
    EDNYGACKDF GVTLYPTFRF FKAFTKEFTQ GENYKAVGDR EIQTVRQVII 150
    DFLQTSPAES KPQAWPSLEP ISSSEISSLL TPKQSHYTAI IFESEESYEG 200
    REVILDLIQY SNIVVRRALP SDKPILEKLG IGSVPSCYLI QPNGLHGLIN 250
    DVKSIRSQLS LHLKALSNVR KLLPSETAHS GLSKGVQQED TTMNQFDRSK 300
    LYMTDLESGL HYILRAELAN HHTLEGEKLK TFKDFVTILY KLFPGRPHVM 350
    KLLETLQEWL VSMPLDTIPY DAILDLVNNK MRISGIFLTN HTQWVGCRGS 400
    KSNLRGYPCS LWKLFHSLTV QAAVKPDALA NTAFEAEPRA VLQTMRRYIR 450
    EFFGCRECAK HFEAMAKETV DSVKTPDQAI LWLWRKHNVV NNRLSGAPSE 500
    DPKFPKVQWP TSDLCSACHS QTGGVHSWNE DEVLAFLKRY YGNQEISLEF 550
    ADPRKDLSEA ATDNGNKEPH FTKKPQERDY VKKQNPQFLD KLVQKKPEKS 600
    LDSEAAESSQ SVSFLGIGFS NIDMSLCVIL YVTSSLFLMI MFFFFRFRSK 650
    RWKVRYNRPF V 661
    Length:661
    Mass (Da):75,121
    Last modified:September 13, 2004 - v1
    Checksum:i6D2CF79098B20188
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079798 mRNA. Translation: AAH79798.1.
    RefSeqiNP_001087446.1. NM_001093977.1.
    UniGeneiXl.46319.

    Genome annotation databases

    GeneIDi447270.
    KEGGixla:447270.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079798 mRNA. Translation: AAH79798.1 .
    RefSeqi NP_001087446.1. NM_001093977.1.
    UniGenei Xl.46319.

    3D structure databases

    ProteinModelPortali Q6AX23.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 447270.
    KEGGi xla:447270.

    Organism-specific databases

    CTDi 169714.
    Xenbasei XB-GENE-986401. qsox2.

    Phylogenomic databases

    HOVERGENi HBG080360.
    KOi K10758.

    Family and domain databases

    Gene3Di 1.20.120.310. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR017905. ERV/ALR_sulphydryl_oxidase.
    IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF04777. Evr1_Alr. 1 hit.
    PF00085. Thioredoxin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    SSF69000. SSF69000. 1 hit.
    PROSITEi PS51324. ERV_ALR. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiQSOX2_XENLA
    AccessioniPrimary (citable) accession number: Q6AX23
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3