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Q6AX23

- QSOX2_XENLA

UniProt

Q6AX23 - QSOX2_XENLA

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Protein
Sulfhydryl oxidase 2
Gene
qsox2, qscn6l1
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins By similarity.

Catalytic activityi

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactori

Binds 1 FAD per subunit Reviewed prediction.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei67 – 671Nucleophile By similarity
Active sitei70 – 701Nucleophile By similarity
Binding sitei405 – 4051FAD By similarity
Binding sitei412 – 4121FAD By similarity
Binding sitei416 – 4161FAD By similarity
Binding sitei457 – 4571FAD By similarity
Binding sitei461 – 4611FAD By similarity
Binding sitei506 – 5061FAD By similarity
Binding sitei509 – 5091FAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi484 – 4918FAD By similarity

GO - Molecular functioni

  1. thiol oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfhydryl oxidase 2 (EC:1.8.3.2)
Alternative name(s):
Quiescin Q6-like protein 1
Gene namesi
Name:qsox2
Synonyms:qscn6l1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-986401. qsox2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei625 – 64521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed prediction
Add
BLAST
Chaini30 – 661632Sulfhydryl oxidase 2
PRO_0000249540Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi67 ↔ 70Redox-active By similarity
Glycosylationi390 – 3901N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi397 ↔ 409 By similarity
Disulfide bondi455 ↔ 458 By similarity
Disulfide bondi515 ↔ 518 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ6AX23.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 155126Thioredoxin
Add
BLAST
Domaini400 – 509110ERV/ALR sulfhydryl oxidase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi642 – 6476Poly-Phe

Sequence similaritiesi

Contains 1 thioredoxin domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG080360.
KOiK10758.

Family and domain databases

Gene3Di1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEiPS51324. ERV_ALR. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AX23-1 [UniParc]FASTAAdd to Basket

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MAAFVGLPLR SVPMLLLLLL LVVAGTARGE TLYGPEDSVT ILNKESVARA    50
VFNSSSAWLL EFYSSWCGHC INYAPTWKAL ARDVRDWEPA IKIGVLDCAE 100
EDNYGACKDF GVTLYPTFRF FKAFTKEFTQ GENYKAVGDR EIQTVRQVII 150
DFLQTSPAES KPQAWPSLEP ISSSEISSLL TPKQSHYTAI IFESEESYEG 200
REVILDLIQY SNIVVRRALP SDKPILEKLG IGSVPSCYLI QPNGLHGLIN 250
DVKSIRSQLS LHLKALSNVR KLLPSETAHS GLSKGVQQED TTMNQFDRSK 300
LYMTDLESGL HYILRAELAN HHTLEGEKLK TFKDFVTILY KLFPGRPHVM 350
KLLETLQEWL VSMPLDTIPY DAILDLVNNK MRISGIFLTN HTQWVGCRGS 400
KSNLRGYPCS LWKLFHSLTV QAAVKPDALA NTAFEAEPRA VLQTMRRYIR 450
EFFGCRECAK HFEAMAKETV DSVKTPDQAI LWLWRKHNVV NNRLSGAPSE 500
DPKFPKVQWP TSDLCSACHS QTGGVHSWNE DEVLAFLKRY YGNQEISLEF 550
ADPRKDLSEA ATDNGNKEPH FTKKPQERDY VKKQNPQFLD KLVQKKPEKS 600
LDSEAAESSQ SVSFLGIGFS NIDMSLCVIL YVTSSLFLMI MFFFFRFRSK 650
RWKVRYNRPF V 661
Length:661
Mass (Da):75,121
Last modified:September 13, 2004 - v1
Checksum:i6D2CF79098B20188
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC079798 mRNA. Translation: AAH79798.1.
RefSeqiNP_001087446.1. NM_001093977.1.
UniGeneiXl.46319.

Genome annotation databases

GeneIDi447270.
KEGGixla:447270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC079798 mRNA. Translation: AAH79798.1 .
RefSeqi NP_001087446.1. NM_001093977.1.
UniGenei Xl.46319.

3D structure databases

ProteinModelPortali Q6AX23.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 447270.
KEGGi xla:447270.

Organism-specific databases

CTDi 169714.
Xenbasei XB-GENE-986401. qsox2.

Phylogenomic databases

HOVERGENi HBG080360.
KOi K10758.

Family and domain databases

Gene3Di 1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEi PS51324. ERV_ALR. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiQSOX2_XENLA
AccessioniPrimary (citable) accession number: Q6AX23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 13, 2004
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi