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Q6AX23

- QSOX2_XENLA

UniProt

Q6AX23 - QSOX2_XENLA

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Protein

Sulfhydryl oxidase 2

Gene

qsox2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins By similarity.By similarity

Catalytic activityi

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactori

Binds 1 FAD per subunit.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei67 – 671NucleophileBy similarity
Active sitei70 – 701NucleophileBy similarity
Binding sitei405 – 4051FADBy similarity
Binding sitei412 – 4121FADBy similarity
Binding sitei416 – 4161FADBy similarity
Binding sitei457 – 4571FADBy similarity
Binding sitei461 – 4611FADBy similarity
Binding sitei506 – 5061FADBy similarity
Binding sitei509 – 5091FADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi484 – 4918FADBy similarity

GO - Molecular functioni

  1. thiol oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfhydryl oxidase 2 (EC:1.8.3.2)
Alternative name(s):
Quiescin Q6-like protein 1
Gene namesi
Name:qsox2
Synonyms:qscn6l1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-986401. qsox2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 661632Sulfhydryl oxidase 2PRO_0000249540Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi67 ↔ 70Redox-activePROSITE-ProRule annotation
Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi397 ↔ 409PROSITE-ProRule annotation
Disulfide bondi455 ↔ 458PROSITE-ProRule annotation
Disulfide bondi515 ↔ 518PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ6AX23.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei625 – 64521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 155126ThioredoxinPROSITE-ProRule annotationAdd
BLAST
Domaini400 – 509110ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi642 – 6476Poly-Phe

Sequence similaritiesi

Contains 1 ERV/ALR sulfhydryl oxidase domain.PROSITE-ProRule annotation
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG080360.
KOiK10758.

Family and domain databases

Gene3Di1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEiPS51324. ERV_ALR. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AX23-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAFVGLPLR SVPMLLLLLL LVVAGTARGE TLYGPEDSVT ILNKESVARA
60 70 80 90 100
VFNSSSAWLL EFYSSWCGHC INYAPTWKAL ARDVRDWEPA IKIGVLDCAE
110 120 130 140 150
EDNYGACKDF GVTLYPTFRF FKAFTKEFTQ GENYKAVGDR EIQTVRQVII
160 170 180 190 200
DFLQTSPAES KPQAWPSLEP ISSSEISSLL TPKQSHYTAI IFESEESYEG
210 220 230 240 250
REVILDLIQY SNIVVRRALP SDKPILEKLG IGSVPSCYLI QPNGLHGLIN
260 270 280 290 300
DVKSIRSQLS LHLKALSNVR KLLPSETAHS GLSKGVQQED TTMNQFDRSK
310 320 330 340 350
LYMTDLESGL HYILRAELAN HHTLEGEKLK TFKDFVTILY KLFPGRPHVM
360 370 380 390 400
KLLETLQEWL VSMPLDTIPY DAILDLVNNK MRISGIFLTN HTQWVGCRGS
410 420 430 440 450
KSNLRGYPCS LWKLFHSLTV QAAVKPDALA NTAFEAEPRA VLQTMRRYIR
460 470 480 490 500
EFFGCRECAK HFEAMAKETV DSVKTPDQAI LWLWRKHNVV NNRLSGAPSE
510 520 530 540 550
DPKFPKVQWP TSDLCSACHS QTGGVHSWNE DEVLAFLKRY YGNQEISLEF
560 570 580 590 600
ADPRKDLSEA ATDNGNKEPH FTKKPQERDY VKKQNPQFLD KLVQKKPEKS
610 620 630 640 650
LDSEAAESSQ SVSFLGIGFS NIDMSLCVIL YVTSSLFLMI MFFFFRFRSK
660
RWKVRYNRPF V
Length:661
Mass (Da):75,121
Last modified:September 13, 2004 - v1
Checksum:i6D2CF79098B20188
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC079798 mRNA. Translation: AAH79798.1.
RefSeqiNP_001087446.1. NM_001093977.1.
UniGeneiXl.46319.

Genome annotation databases

GeneIDi447270.
KEGGixla:447270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC079798 mRNA. Translation: AAH79798.1 .
RefSeqi NP_001087446.1. NM_001093977.1.
UniGenei Xl.46319.

3D structure databases

ProteinModelPortali Q6AX23.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 447270.
KEGGi xla:447270.

Organism-specific databases

CTDi 169714.
Xenbasei XB-GENE-986401. qsox2.

Phylogenomic databases

HOVERGENi HBG080360.
KOi K10758.

Family and domain databases

Gene3Di 1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEi PS51324. ERV_ALR. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiQSOX2_XENLA
AccessioniPrimary (citable) accession number: Q6AX23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 13, 2004
Last modified: October 1, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3