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Q6AX23 (QSOX2_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sulfhydryl oxidase 2

EC=1.8.3.2
Alternative name(s):
Quiescin Q6-like protein 1
Gene names
Name:qsox2
Synonyms:qscn6l1
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length661 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins By similarity.

Catalytic activity

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactor

Binds 1 FAD per subunit Potential.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.

Contains 1 ERV/ALR sulfhydryl oxidase domain.

Contains 1 thioredoxin domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Biological_processcell redox homeostasis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionthiol oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 661632Sulfhydryl oxidase 2
PRO_0000249540

Regions

Transmembrane625 – 64521Helical; Potential
Domain30 – 155126Thioredoxin
Domain400 – 509110ERV/ALR sulfhydryl oxidase
Nucleotide binding484 – 4918FAD By similarity
Compositional bias642 – 6476Poly-Phe

Sites

Active site671Nucleophile By similarity
Active site701Nucleophile By similarity
Binding site4051FAD By similarity
Binding site4121FAD By similarity
Binding site4161FAD By similarity
Binding site4571FAD By similarity
Binding site4611FAD By similarity
Binding site5061FAD By similarity
Binding site5091FAD By similarity

Amino acid modifications

Glycosylation531N-linked (GlcNAc...) Potential
Glycosylation3901N-linked (GlcNAc...) Potential
Disulfide bond67 ↔ 70Redox-active By similarity
Disulfide bond397 ↔ 409 By similarity
Disulfide bond455 ↔ 458 By similarity
Disulfide bond515 ↔ 518 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AX23 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 6D2CF79098B20188

FASTA66175,121
        10         20         30         40         50         60 
MAAFVGLPLR SVPMLLLLLL LVVAGTARGE TLYGPEDSVT ILNKESVARA VFNSSSAWLL 

        70         80         90        100        110        120 
EFYSSWCGHC INYAPTWKAL ARDVRDWEPA IKIGVLDCAE EDNYGACKDF GVTLYPTFRF 

       130        140        150        160        170        180 
FKAFTKEFTQ GENYKAVGDR EIQTVRQVII DFLQTSPAES KPQAWPSLEP ISSSEISSLL 

       190        200        210        220        230        240 
TPKQSHYTAI IFESEESYEG REVILDLIQY SNIVVRRALP SDKPILEKLG IGSVPSCYLI 

       250        260        270        280        290        300 
QPNGLHGLIN DVKSIRSQLS LHLKALSNVR KLLPSETAHS GLSKGVQQED TTMNQFDRSK 

       310        320        330        340        350        360 
LYMTDLESGL HYILRAELAN HHTLEGEKLK TFKDFVTILY KLFPGRPHVM KLLETLQEWL 

       370        380        390        400        410        420 
VSMPLDTIPY DAILDLVNNK MRISGIFLTN HTQWVGCRGS KSNLRGYPCS LWKLFHSLTV 

       430        440        450        460        470        480 
QAAVKPDALA NTAFEAEPRA VLQTMRRYIR EFFGCRECAK HFEAMAKETV DSVKTPDQAI 

       490        500        510        520        530        540 
LWLWRKHNVV NNRLSGAPSE DPKFPKVQWP TSDLCSACHS QTGGVHSWNE DEVLAFLKRY 

       550        560        570        580        590        600 
YGNQEISLEF ADPRKDLSEA ATDNGNKEPH FTKKPQERDY VKKQNPQFLD KLVQKKPEKS 

       610        620        630        640        650        660 
LDSEAAESSQ SVSFLGIGFS NIDMSLCVIL YVTSSLFLMI MFFFFRFRSK RWKVRYNRPF 


V 

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References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC079798 mRNA. Translation: AAH79798.1.
RefSeqNP_001087446.1. NM_001093977.1.
UniGeneXl.46319.

3D structure databases

ProteinModelPortalQ6AX23.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID447270.
KEGGxla:447270.

Organism-specific databases

CTD169714.
XenbaseXB-GENE-986401. qsox2.

Phylogenomic databases

HOVERGENHBG080360.
KOK10758.

Family and domain databases

Gene3D1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProIPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamPF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEPS51324. ERV_ALR. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQSOX2_XENLA
AccessionPrimary (citable) accession number: Q6AX23
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 13, 2004
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families