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Protein

Zinc finger protein 324B

Gene

ZNF324B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri257 – 279C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-32378-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 324B
Gene namesi
Name:ZNF324B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:33107. ZNF324B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000249471.
PharmGKBiPA162410082.

Polymorphism and mutation databases

BioMutaiZNF324B.
DMDMi74757410.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804051 – 544Zinc finger protein 324BAdd BLAST544

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki214Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ6AW86.
PaxDbiQ6AW86.
PeptideAtlasiQ6AW86.
PRIDEiQ6AW86.

PTM databases

iPTMnetiQ6AW86.
PhosphoSitePlusiQ6AW86.

Expressioni

Gene expression databases

BgeeiENSG00000249471.
CleanExiHS_ZNF324B.
ExpressionAtlasiQ6AW86. baseline and differential.
GenevisibleiQ6AW86. HS.

Organism-specific databases

HPAiHPA023400.

Interactioni

Protein-protein interaction databases

BioGridi132751. 78 interactors.
IntActiQ6AW86. 1 interactor.
STRINGi9606.ENSP00000337473.

Structurei

3D structure databases

ProteinModelPortaliQ6AW86.
SMRiQ6AW86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 72KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri257 – 279C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000130002.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6AW86.
KOiK09228.
OMAiTFTEYRV.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6AW86.
TreeFamiTF337574.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6AW86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTFEDVAVYF SQEEWGLLDT AQRALYRHVM LENFTLVTSL GLSTSRPRVV
60 70 80 90 100
IQLERGEEPW VPSGKDMTLA RNTYGRLNSG SWSLTEDRDV SGEWPRAFPD
110 120 130 140 150
TPPGMTTSVF PVADACHSVK SLQRQPGASP SQERKPTGVS VIYWERLLLG
160 170 180 190 200
SRSDQASISL RLTSPLRPPK SSRPREKTFT EYRVPGRQPR TPERQKPCAQ
210 220 230 240 250
EVPGRAFGNA SDLKAASGGR DRRMGAAWQE PHRLLGGQEP STWDELGEAL
260 270 280 290 300
HAGEKSFECR ACSKVFVKSS DLLKHLRTHT GERPYECTQC GKAFSQTSHL
310 320 330 340 350
TQHQRIHSGE TPYACPVCGK AFRHSSSLVR HQRIHTAEKS FRCSECGKAF
360 370 380 390 400
SHGSNLSQHR KIHAGGRPYA CAQCGRRFCR NSHLIQHERT HTGEKPFVCA
410 420 430 440 450
LCGAAFSQGS SLFLHQRVHT GEKPFACAQC GRSFSRSSNL TQHQLLHTGE
460 470 480 490 500
RPFRCVDCGK GFAKGAVLLS HRRIHTGEKP FVCTQCGRAF RERPALLHHQ
510 520 530 540
RIHTTEKTNA AAPDCTPGPG FLQGHHRKVR RGGKPSPVLK PAKV
Length:544
Mass (Da):60,602
Last modified:September 13, 2004 - v1
Checksum:i7CC2D443961CA98D
GO
Isoform 2 (identifier: Q6AW86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: MTFEDVAVYF...ARNTYGRLNS → MGVPTAVSAT...PQATTVSLRL

Note: No experimental confirmation available.
Show »
Length:534
Mass (Da):58,806
Checksum:i0B2458BBF618BDC9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti402C → R in BAD18597 (PubMed:14702039).Curated1
Sequence conflicti457D → G in BAC87113 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05281163S → G.Corresponds to variant rs12611254dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0236581 – 79MTFED…GRLNS → MGVPTAVSATPVRADASSKP QPLLQSQPHLFFFPKLLSRL LGSPLPVHSAGPGPLLTRMP QATTVSLRL in isoform 2. 1 PublicationAdd BLAST79

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127750 mRNA. Translation: BAC87113.1.
AK131452 mRNA. Translation: BAD18597.1.
BX648711 mRNA. Translation: CAH10556.1.
BC140881 mRNA. Translation: AAI40882.1.
BC140882 mRNA. Translation: AAI40883.1.
CCDSiCCDS33138.1. [Q6AW86-1]
RefSeqiNP_997278.2. NM_207395.2. [Q6AW86-1]
XP_005258972.1. XM_005258915.4. [Q6AW86-1]
XP_005258975.1. XM_005258918.4. [Q6AW86-1]
UniGeneiHs.186970.

Genome annotation databases

EnsembliENST00000336614; ENSP00000337473; ENSG00000249471. [Q6AW86-1]
ENST00000545523; ENSP00000438930; ENSG00000249471. [Q6AW86-1]
GeneIDi388569.
KEGGihsa:388569.
UCSCiuc002qsv.2. human. [Q6AW86-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127750 mRNA. Translation: BAC87113.1.
AK131452 mRNA. Translation: BAD18597.1.
BX648711 mRNA. Translation: CAH10556.1.
BC140881 mRNA. Translation: AAI40882.1.
BC140882 mRNA. Translation: AAI40883.1.
CCDSiCCDS33138.1. [Q6AW86-1]
RefSeqiNP_997278.2. NM_207395.2. [Q6AW86-1]
XP_005258972.1. XM_005258915.4. [Q6AW86-1]
XP_005258975.1. XM_005258918.4. [Q6AW86-1]
UniGeneiHs.186970.

3D structure databases

ProteinModelPortaliQ6AW86.
SMRiQ6AW86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132751. 78 interactors.
IntActiQ6AW86. 1 interactor.
STRINGi9606.ENSP00000337473.

PTM databases

iPTMnetiQ6AW86.
PhosphoSitePlusiQ6AW86.

Polymorphism and mutation databases

BioMutaiZNF324B.
DMDMi74757410.

Proteomic databases

MaxQBiQ6AW86.
PaxDbiQ6AW86.
PeptideAtlasiQ6AW86.
PRIDEiQ6AW86.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336614; ENSP00000337473; ENSG00000249471. [Q6AW86-1]
ENST00000545523; ENSP00000438930; ENSG00000249471. [Q6AW86-1]
GeneIDi388569.
KEGGihsa:388569.
UCSCiuc002qsv.2. human. [Q6AW86-1]

Organism-specific databases

CTDi388569.
GeneCardsiZNF324B.
HGNCiHGNC:33107. ZNF324B.
HPAiHPA023400.
neXtProtiNX_Q6AW86.
OpenTargetsiENSG00000249471.
PharmGKBiPA162410082.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000130002.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6AW86.
KOiK09228.
OMAiTFTEYRV.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6AW86.
TreeFamiTF337574.

Enzyme and pathway databases

BioCyciZFISH:G66-32378-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii388569.
PROiQ6AW86.

Gene expression databases

BgeeiENSG00000249471.
CleanExiHS_ZNF324B.
ExpressionAtlasiQ6AW86. baseline and differential.
GenevisibleiQ6AW86. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZ324B_HUMAN
AccessioniPrimary (citable) accession number: Q6AW86
Secondary accession number(s): B2RTZ6, Q6ZMX8, Q6ZS42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: September 13, 2004
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.