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Q6AW86

- Z324B_HUMAN

UniProt

Q6AW86 - Z324B_HUMAN

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Protein

Zinc finger protein 324B

Gene

ZNF324B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri257 – 27923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri453 – 47523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri481 – 50323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 324B
Gene namesi
Name:ZNF324B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:33107. ZNF324B.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410082.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 544544Zinc finger protein 324BPRO_0000280405Add
BLAST

Proteomic databases

MaxQBiQ6AW86.
PaxDbiQ6AW86.
PRIDEiQ6AW86.

Expressioni

Gene expression databases

BgeeiQ6AW86.
CleanExiHS_ZNF324B.
ExpressionAtlasiQ6AW86. baseline.
GenevestigatoriQ6AW86.

Organism-specific databases

HPAiHPA023400.

Interactioni

Protein-protein interaction databases

BioGridi132751. 3 interactions.
IntActiQ6AW86. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6AW86.
SMRiQ6AW86. Positions 1-41, 151-504.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7272KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri257 – 27923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri453 – 47523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri481 – 50323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119420.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6AW86.
KOiK09228.
OMAiLNSGSWS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6AW86.
TreeFamiTF337574.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6AW86-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTFEDVAVYF SQEEWGLLDT AQRALYRHVM LENFTLVTSL GLSTSRPRVV
60 70 80 90 100
IQLERGEEPW VPSGKDMTLA RNTYGRLNSG SWSLTEDRDV SGEWPRAFPD
110 120 130 140 150
TPPGMTTSVF PVADACHSVK SLQRQPGASP SQERKPTGVS VIYWERLLLG
160 170 180 190 200
SRSDQASISL RLTSPLRPPK SSRPREKTFT EYRVPGRQPR TPERQKPCAQ
210 220 230 240 250
EVPGRAFGNA SDLKAASGGR DRRMGAAWQE PHRLLGGQEP STWDELGEAL
260 270 280 290 300
HAGEKSFECR ACSKVFVKSS DLLKHLRTHT GERPYECTQC GKAFSQTSHL
310 320 330 340 350
TQHQRIHSGE TPYACPVCGK AFRHSSSLVR HQRIHTAEKS FRCSECGKAF
360 370 380 390 400
SHGSNLSQHR KIHAGGRPYA CAQCGRRFCR NSHLIQHERT HTGEKPFVCA
410 420 430 440 450
LCGAAFSQGS SLFLHQRVHT GEKPFACAQC GRSFSRSSNL TQHQLLHTGE
460 470 480 490 500
RPFRCVDCGK GFAKGAVLLS HRRIHTGEKP FVCTQCGRAF RERPALLHHQ
510 520 530 540
RIHTTEKTNA AAPDCTPGPG FLQGHHRKVR RGGKPSPVLK PAKV
Length:544
Mass (Da):60,602
Last modified:September 13, 2004 - v1
Checksum:i7CC2D443961CA98D
GO
Isoform 2 (identifier: Q6AW86-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: MTFEDVAVYF...ARNTYGRLNS → MGVPTAVSAT...PQATTVSLRL

Note: No experimental confirmation available.

Show »
Length:534
Mass (Da):58,806
Checksum:i0B2458BBF618BDC9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti402 – 4021C → R in BAD18597. (PubMed:14702039)Curated
Sequence conflicti457 – 4571D → G in BAC87113. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631S → G.
Corresponds to variant rs12611254 [ dbSNP | Ensembl ].
VAR_052811

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7979MTFED…GRLNS → MGVPTAVSATPVRADASSKP QPLLQSQPHLFFFPKLLSRL LGSPLPVHSAGPGPLLTRMP QATTVSLRL in isoform 2. 1 PublicationVSP_023658Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK127750 mRNA. Translation: BAC87113.1.
AK131452 mRNA. Translation: BAD18597.1.
BX648711 mRNA. Translation: CAH10556.1.
BC140881 mRNA. Translation: AAI40882.1.
BC140882 mRNA. Translation: AAI40883.1.
CCDSiCCDS33138.1. [Q6AW86-1]
RefSeqiNP_997278.2. NM_207395.2. [Q6AW86-1]
XP_005258971.1. XM_005258914.2. [Q6AW86-1]
XP_005258972.1. XM_005258915.2. [Q6AW86-1]
XP_005258973.1. XM_005258916.2. [Q6AW86-1]
XP_005258974.1. XM_005258917.2. [Q6AW86-1]
XP_005258975.1. XM_005258918.2. [Q6AW86-1]
UniGeneiHs.186970.

Genome annotation databases

EnsembliENST00000336614; ENSP00000337473; ENSG00000249471. [Q6AW86-1]
ENST00000545523; ENSP00000438930; ENSG00000249471. [Q6AW86-1]
GeneIDi388569.
KEGGihsa:388569.
UCSCiuc002qsv.1. human. [Q6AW86-1]

Polymorphism databases

DMDMi74757410.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK127750 mRNA. Translation: BAC87113.1 .
AK131452 mRNA. Translation: BAD18597.1 .
BX648711 mRNA. Translation: CAH10556.1 .
BC140881 mRNA. Translation: AAI40882.1 .
BC140882 mRNA. Translation: AAI40883.1 .
CCDSi CCDS33138.1. [Q6AW86-1 ]
RefSeqi NP_997278.2. NM_207395.2. [Q6AW86-1 ]
XP_005258971.1. XM_005258914.2. [Q6AW86-1 ]
XP_005258972.1. XM_005258915.2. [Q6AW86-1 ]
XP_005258973.1. XM_005258916.2. [Q6AW86-1 ]
XP_005258974.1. XM_005258917.2. [Q6AW86-1 ]
XP_005258975.1. XM_005258918.2. [Q6AW86-1 ]
UniGenei Hs.186970.

3D structure databases

ProteinModelPortali Q6AW86.
SMRi Q6AW86. Positions 1-41, 151-504.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 132751. 3 interactions.
IntActi Q6AW86. 1 interaction.

Polymorphism databases

DMDMi 74757410.

Proteomic databases

MaxQBi Q6AW86.
PaxDbi Q6AW86.
PRIDEi Q6AW86.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000336614 ; ENSP00000337473 ; ENSG00000249471 . [Q6AW86-1 ]
ENST00000545523 ; ENSP00000438930 ; ENSG00000249471 . [Q6AW86-1 ]
GeneIDi 388569.
KEGGi hsa:388569.
UCSCi uc002qsv.1. human. [Q6AW86-1 ]

Organism-specific databases

CTDi 388569.
GeneCardsi GC19P059279.
HGNCi HGNC:33107. ZNF324B.
HPAi HPA023400.
neXtProti NX_Q6AW86.
PharmGKBi PA162410082.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000119420.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q6AW86.
KOi K09228.
OMAi LNSGSWS.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q6AW86.
TreeFami TF337574.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 388569.
NextBioi 102176.
PROi Q6AW86.

Gene expression databases

Bgeei Q6AW86.
CleanExi HS_ZNF324B.
ExpressionAtlasi Q6AW86. baseline.
Genevestigatori Q6AW86.

Family and domain databases

Gene3Di 3.30.160.60. 9 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Endometrial adenocarcinoma.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiZ324B_HUMAN
AccessioniPrimary (citable) accession number: Q6AW86
Secondary accession number(s): B2RTZ6, Q6ZMX8, Q6ZS42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: September 13, 2004
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3