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Q6AW86

- Z324B_HUMAN

UniProt

Q6AW86 - Z324B_HUMAN

Protein

Zinc finger protein 324B

Gene

ZNF324B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri257 – 27923C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri285 – 30723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri313 – 33523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri341 – 36323C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri369 – 39123C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri397 – 41923C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri425 – 44723C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri453 – 47523C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri481 – 50323C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 324B
    Gene namesi
    Name:ZNF324B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:33107. ZNF324B.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162410082.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 544544Zinc finger protein 324BPRO_0000280405Add
    BLAST

    Proteomic databases

    PaxDbiQ6AW86.
    PRIDEiQ6AW86.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6AW86.
    BgeeiQ6AW86.
    CleanExiHS_ZNF324B.
    GenevestigatoriQ6AW86.

    Organism-specific databases

    HPAiHPA023400.

    Interactioni

    Protein-protein interaction databases

    BioGridi132751. 3 interactions.
    IntActiQ6AW86. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AW86.
    SMRiQ6AW86. Positions 1-41, 151-535.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 7272KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri257 – 27923C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri285 – 30723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri313 – 33523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri341 – 36323C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri369 – 39123C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri397 – 41923C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri425 – 44723C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri453 – 47523C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri481 – 50323C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ6AW86.
    KOiK09228.
    OMAiLNSGSWS.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ6AW86.
    TreeFamiTF337574.

    Family and domain databases

    Gene3Di3.30.160.60. 9 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 9 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 9 hits.
    PS50157. ZINC_FINGER_C2H2_2. 9 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6AW86-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTFEDVAVYF SQEEWGLLDT AQRALYRHVM LENFTLVTSL GLSTSRPRVV    50
    IQLERGEEPW VPSGKDMTLA RNTYGRLNSG SWSLTEDRDV SGEWPRAFPD 100
    TPPGMTTSVF PVADACHSVK SLQRQPGASP SQERKPTGVS VIYWERLLLG 150
    SRSDQASISL RLTSPLRPPK SSRPREKTFT EYRVPGRQPR TPERQKPCAQ 200
    EVPGRAFGNA SDLKAASGGR DRRMGAAWQE PHRLLGGQEP STWDELGEAL 250
    HAGEKSFECR ACSKVFVKSS DLLKHLRTHT GERPYECTQC GKAFSQTSHL 300
    TQHQRIHSGE TPYACPVCGK AFRHSSSLVR HQRIHTAEKS FRCSECGKAF 350
    SHGSNLSQHR KIHAGGRPYA CAQCGRRFCR NSHLIQHERT HTGEKPFVCA 400
    LCGAAFSQGS SLFLHQRVHT GEKPFACAQC GRSFSRSSNL TQHQLLHTGE 450
    RPFRCVDCGK GFAKGAVLLS HRRIHTGEKP FVCTQCGRAF RERPALLHHQ 500
    RIHTTEKTNA AAPDCTPGPG FLQGHHRKVR RGGKPSPVLK PAKV 544
    Length:544
    Mass (Da):60,602
    Last modified:September 13, 2004 - v1
    Checksum:i7CC2D443961CA98D
    GO
    Isoform 2 (identifier: Q6AW86-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-79: MTFEDVAVYF...ARNTYGRLNS → MGVPTAVSAT...PQATTVSLRL

    Note: No experimental confirmation available.

    Show »
    Length:534
    Mass (Da):58,806
    Checksum:i0B2458BBF618BDC9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti402 – 4021C → R in BAD18597. (PubMed:14702039)Curated
    Sequence conflicti457 – 4571D → G in BAC87113. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti63 – 631S → G.
    Corresponds to variant rs12611254 [ dbSNP | Ensembl ].
    VAR_052811

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7979MTFED…GRLNS → MGVPTAVSATPVRADASSKP QPLLQSQPHLFFFPKLLSRL LGSPLPVHSAGPGPLLTRMP QATTVSLRL in isoform 2. 1 PublicationVSP_023658Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK127750 mRNA. Translation: BAC87113.1.
    AK131452 mRNA. Translation: BAD18597.1.
    BX648711 mRNA. Translation: CAH10556.1.
    BC140881 mRNA. Translation: AAI40882.1.
    BC140882 mRNA. Translation: AAI40883.1.
    CCDSiCCDS33138.1. [Q6AW86-1]
    RefSeqiNP_997278.2. NM_207395.2. [Q6AW86-1]
    XP_005258971.1. XM_005258914.2. [Q6AW86-1]
    XP_005258972.1. XM_005258915.2. [Q6AW86-1]
    XP_005258973.1. XM_005258916.2. [Q6AW86-1]
    XP_005258974.1. XM_005258917.2. [Q6AW86-1]
    XP_005258975.1. XM_005258918.2. [Q6AW86-1]
    UniGeneiHs.186970.

    Genome annotation databases

    EnsembliENST00000336614; ENSP00000337473; ENSG00000249471. [Q6AW86-1]
    ENST00000545523; ENSP00000438930; ENSG00000249471. [Q6AW86-1]
    GeneIDi388569.
    KEGGihsa:388569.
    UCSCiuc002qsv.1. human. [Q6AW86-1]

    Polymorphism databases

    DMDMi74757410.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK127750 mRNA. Translation: BAC87113.1 .
    AK131452 mRNA. Translation: BAD18597.1 .
    BX648711 mRNA. Translation: CAH10556.1 .
    BC140881 mRNA. Translation: AAI40882.1 .
    BC140882 mRNA. Translation: AAI40883.1 .
    CCDSi CCDS33138.1. [Q6AW86-1 ]
    RefSeqi NP_997278.2. NM_207395.2. [Q6AW86-1 ]
    XP_005258971.1. XM_005258914.2. [Q6AW86-1 ]
    XP_005258972.1. XM_005258915.2. [Q6AW86-1 ]
    XP_005258973.1. XM_005258916.2. [Q6AW86-1 ]
    XP_005258974.1. XM_005258917.2. [Q6AW86-1 ]
    XP_005258975.1. XM_005258918.2. [Q6AW86-1 ]
    UniGenei Hs.186970.

    3D structure databases

    ProteinModelPortali Q6AW86.
    SMRi Q6AW86. Positions 1-41, 151-535.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 132751. 3 interactions.
    IntActi Q6AW86. 1 interaction.

    Polymorphism databases

    DMDMi 74757410.

    Proteomic databases

    PaxDbi Q6AW86.
    PRIDEi Q6AW86.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336614 ; ENSP00000337473 ; ENSG00000249471 . [Q6AW86-1 ]
    ENST00000545523 ; ENSP00000438930 ; ENSG00000249471 . [Q6AW86-1 ]
    GeneIDi 388569.
    KEGGi hsa:388569.
    UCSCi uc002qsv.1. human. [Q6AW86-1 ]

    Organism-specific databases

    CTDi 388569.
    GeneCardsi GC19P059230.
    HGNCi HGNC:33107. ZNF324B.
    HPAi HPA023400.
    neXtProti NX_Q6AW86.
    PharmGKBi PA162410082.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q6AW86.
    KOi K09228.
    OMAi LNSGSWS.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q6AW86.
    TreeFami TF337574.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 388569.
    NextBioi 102176.
    PROi Q6AW86.

    Gene expression databases

    ArrayExpressi Q6AW86.
    Bgeei Q6AW86.
    CleanExi HS_ZNF324B.
    Genevestigatori Q6AW86.

    Family and domain databases

    Gene3Di 3.30.160.60. 9 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 9 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 9 hits.
    PS50157. ZINC_FINGER_C2H2_2. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Endometrial adenocarcinoma.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

    Entry informationi

    Entry nameiZ324B_HUMAN
    AccessioniPrimary (citable) accession number: Q6AW86
    Secondary accession number(s): B2RTZ6, Q6ZMX8, Q6ZS42
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3