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Protein

Carboxylesterase 5A

Gene

CES5A

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.By similarity

Catalytic activityi

A carboxylic ester + H2O = an alcohol + a carboxylate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei226 – 2261Acyl-ester intermediatePROSITE-ProRule annotation
Active sitei345 – 3451Charge relay systemBy similarity
Active sitei454 – 4541Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Protein family/group databases

ESTHERicanfa-cauxin. Carb_B_Chordata.
MEROPSiS09.960.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxylesterase 5A (EC:3.1.1.1)
Alternative name(s):
Carboxylesterase-like urinary excreted protein homolog
Short name:
Cauxin
Gene namesi
Name:CES5A
Synonyms:CES7
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 575548Carboxylesterase 5APRO_0000308589Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence analysis
Disulfide bondi94 ↔ 121By similarity
Disulfide bondi280 ↔ 291By similarity
Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence analysis
Glycosylationi363 – 3631N-linked (GlcNAc...)Sequence analysis
Glycosylationi524 – 5241N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6AW47.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000013718.

Structurei

3D structure databases

ProteinModelPortaliQ6AW47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1516. Eukaryota.
COG2272. LUCA.
HOVERGENiHBG008839.
InParanoidiQ6AW47.
KOiK15743.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AW47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGEWGHLGQ TLIWAVWVLA AATEGPAADA PVRSTRLGWV RGKQATVLGS
60 70 80 90 100
TMPVNVFLGI PFAAPPLGPL RFKRPKPALL WNDSRDATSY PKLCLQNSVW
110 120 130 140 150
LLSDQHFLKV HYPNLEVSED CLYLNIYAPA HANTGSKLPV MVWFPGGAFE
160 170 180 190 200
TGSASIFDGS ALAAYEDVLI VTTQYRLGIF GFFKTGDQHA PGNWAFLDQL
210 220 230 240 250
AALTWVQENI EFFGGDPHSV TIFGESAGAI SVSGLVLSPM ASGLFHKAIM
260 270 280 290 300
ESGVAIIPFL RAPDDERNED LQVIARICGC NVSDSVALLQ CLRAKSSEEL
310 320 330 340 350
LDINKKTKSF TRVVDGFFFP DEPLDLLTEK TFNSIPSVIG VNNHECGFLL
360 370 380 390 400
PMKEFPEILG GSNKSLALHL IHRVLHIPNQ YLYLVADQYF YNKHSPVEIR
410 420 430 440 450
DSFLDLLGDV FFVVPGVVTA RYHRDAGAPV YFYEFQHPPE CLKDTRPAFV
460 470 480 490 500
KADHSDEIRF VFGGAFLKGN IVMFEGATEE EKLLSRKMMR YWANFARTGD
510 520 530 540 550
PNGEGLPLWP AYSQSEQYLK LDLNISVGQK LKEQEVEFWS DTLPLIMSMS
560 570
TAPPGPPVPL LSLSVLLPFL FSSAP
Length:575
Mass (Da):63,621
Last modified:September 13, 2004 - v1
Checksum:i1005C35E82E1183D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB186392 mRNA. Translation: BAD35015.1.
RefSeqiNP_001003969.1. NM_001003969.1.
UniGeneiCfa.15821.

Genome annotation databases

GeneIDi445456.
KEGGicfa:445456.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB186392 mRNA. Translation: BAD35015.1.
RefSeqiNP_001003969.1. NM_001003969.1.
UniGeneiCfa.15821.

3D structure databases

ProteinModelPortaliQ6AW47.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000013718.

Protein family/group databases

ESTHERicanfa-cauxin. Carb_B_Chordata.
MEROPSiS09.960.

Proteomic databases

PaxDbiQ6AW47.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi445456.
KEGGicfa:445456.

Organism-specific databases

CTDi221223.

Phylogenomic databases

eggNOGiKOG1516. Eukaryota.
COG2272. LUCA.
HOVERGENiHBG008839.
InParanoidiQ6AW47.
KOiK15743.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEST5A_CANLF
AccessioniPrimary (citable) accession number: Q6AW47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: September 13, 2004
Last modified: June 8, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.