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Protein

Carboxylesterase 5A

Gene

Ces5a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.By similarity

Catalytic activityi

A carboxylic ester + H2O = an alcohol + a carboxylate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei226 – 2261Acyl-ester intermediatePROSITE-ProRule annotation
Active sitei345 – 3451Charge relay systemBy similarity
Active sitei454 – 4541Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Protein family/group databases

ESTHERimouse-cauxin. Carb_B_Chordata.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxylesterase 5A (EC:3.1.1.1)
Alternative name(s):
Carboxylesterase-like urinary excreted protein homolog
Short name:
Cauxin
Gene namesi
Name:Ces5a
Synonyms:Ces7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1915185. Ces5a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 575547Carboxylesterase 5APRO_0000308592Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi94 ↔ 121By similarity
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence analysis
Disulfide bondi280 ↔ 291By similarity
Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence analysis
Glycosylationi363 – 3631N-linked (GlcNAc...)Sequence analysis
Glycosylationi524 – 5241N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ6AW46.
PaxDbiQ6AW46.
PRIDEiQ6AW46.

Expressioni

Gene expression databases

BgeeiQ6AW46.
CleanExiMM_CES7.
ExpressionAtlasiQ6AW46. baseline and differential.
GenevisibleiQ6AW46. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076988.

Structurei

3D structure databases

ProteinModelPortaliQ6AW46.
SMRiQ6AW46. Positions 38-541.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1516. Eukaryota.
COG2272. LUCA.
GeneTreeiENSGT00760000118946.
HOVERGENiHBG008839.
InParanoidiQ6AW46.
KOiK15743.
OMAiWVQGKQV.
OrthoDBiEOG75XGKD.
PhylomeDBiQ6AW46.
TreeFamiTF315470.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AW46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGDWVRPGQ ALIWVIWIFG AIIEGSVTEE PHRYTKLGWV QGKQATVLGR
60 70 80 90 100
LEPVNVFLGI PFAAPPLGPL RFSKPQPPIP WDNLREATAY PNLCFQNLEW
110 120 130 140 150
LFIYQNLLKV SYPILGMSED CLYLNIYAPC HANNGSSLPV MVWIPGGGFE
160 170 180 190 200
TGSASIFDGS ALAVYEDVLV VTIQYRLGIF GFFTTQNQHA PGNWAFWDQL
210 220 230 240 250
AALLWVRENI KYFGGNPDSV TIFGNSAGAI SISSLILSPL SADLFHRAIM
260 270 280 290 300
QSGVAIIPSL KSSDNDLKHD LQVVANVCDC NVSDSKALLK CLREKSSLEL
310 320 330 340 350
MSLSQKAKSF TRVVDGSFFS EEPLELLSQK TLKIVPSIIG VNNQECGYIL
360 370 380 390 400
PVRDTPEILL GSNESTALTL IHTLLHIPTQ HLYIVTKEYF HGKHSPTDIR
410 420 430 440 450
DTLLDLFGDV FFVVPGLVTA RYHRDSGGPV YFYEFQHRPH CFQNSRPAFV
460 470 480 490 500
KADHTDEIRF VFGGPFLKGD VVMFEEATEE EKLLSRKMMK YWANFARSGD
510 520 530 540 550
PNGADLPPWP VYDENEQYLE LDVNISTGRR LKDQRVEFWT DTLPLILSAS
560 570
KALLSPTFSL ILLSLLSPVL LSAAS
Length:575
Mass (Da):64,167
Last modified:September 13, 2004 - v1
Checksum:i3EB9D85981D9DE0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB186393 mRNA. Translation: BAD35016.1.
RefSeqiNP_001003951.1. NM_001003951.2.
UniGeneiMm.200622.
Mm.390064.
Mm.65457.

Genome annotation databases

EnsembliENSMUST00000077816; ENSMUSP00000076988; ENSMUSG00000058019.
GeneIDi67935.
KEGGimmu:67935.
UCSCiuc033jgu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB186393 mRNA. Translation: BAD35016.1.
RefSeqiNP_001003951.1. NM_001003951.2.
UniGeneiMm.200622.
Mm.390064.
Mm.65457.

3D structure databases

ProteinModelPortaliQ6AW46.
SMRiQ6AW46. Positions 38-541.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076988.

Protein family/group databases

ESTHERimouse-cauxin. Carb_B_Chordata.

Proteomic databases

EPDiQ6AW46.
PaxDbiQ6AW46.
PRIDEiQ6AW46.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077816; ENSMUSP00000076988; ENSMUSG00000058019.
GeneIDi67935.
KEGGimmu:67935.
UCSCiuc033jgu.1. mouse.

Organism-specific databases

CTDi221223.
MGIiMGI:1915185. Ces5a.

Phylogenomic databases

eggNOGiKOG1516. Eukaryota.
COG2272. LUCA.
GeneTreeiENSGT00760000118946.
HOVERGENiHBG008839.
InParanoidiQ6AW46.
KOiK15743.
OMAiWVQGKQV.
OrthoDBiEOG75XGKD.
PhylomeDBiQ6AW46.
TreeFamiTF315470.

Miscellaneous databases

ChiTaRSiCes5a. mouse.
PROiQ6AW46.
SOURCEiSearch...

Gene expression databases

BgeeiQ6AW46.
CleanExiMM_CES7.
ExpressionAtlasiQ6AW46. baseline and differential.
GenevisibleiQ6AW46. MM.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Species-, sex-, and age-dependent urinary excretion of cauxin, a mammalian carboxylesterase."
    Miyazaki M., Yamashita T., Hosokawa M., Taira H., Suzuki A.
    Comp. Biochem. Physiol. 145B:270-277(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiEST5A_MOUSE
AccessioniPrimary (citable) accession number: Q6AW46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: September 13, 2004
Last modified: June 8, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.