SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6AUV1

- XDH_ORYSJ

UniProt

Q6AUV1 - XDH_ORYSJ

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Xanthine dehydrogenase
Gene
XDH, Os03g0429800, LOC_Os03g31550, OsJ_11360, OSJNBa0091B22.11
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Key enzyme involved in purine catabolism. Catalyzes the oxidation of hypoxanthine to xanthine and the oxidation of xanthine to urate By similarity.

Catalytic activityi

Xanthine + NAD+ + H2O = urate + NADH.
Hypoxanthine + NAD+ + H2O = xanthine + NADH.

Cofactori

Binds 2 2Fe-2S clusters By similarity.
FAD By similarity.
Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi58 – 581Iron-sulfur (2Fe-2S) 1 By similarity
Metal bindingi63 – 631Iron-sulfur (2Fe-2S) 1 By similarity
Metal bindingi66 – 661Iron-sulfur (2Fe-2S) 1 By similarity
Metal bindingi88 – 881Iron-sulfur (2Fe-2S) 1 By similarity
Metal bindingi128 – 1281Iron-sulfur (2Fe-2S) 2 By similarity
Metal bindingi131 – 1311Iron-sulfur (2Fe-2S) 2 By similarity
Metal bindingi164 – 1641Iron-sulfur (2Fe-2S) 2 By similarity
Metal bindingi166 – 1661Iron-sulfur (2Fe-2S) 2 By similarity
Binding sitei373 – 3731FAD By similarity
Binding sitei396 – 3961FAD By similarity
Binding sitei440 – 4401FAD; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei458 – 4581FAD By similarity
Metal bindingi804 – 8041Molybdenum By similarity
Metal bindingi835 – 8351Molybdenum; via carbonyl oxygen By similarity
Binding sitei839 – 8391Substrate By similarity
Binding sitei917 – 9171Substrate By similarity
Metal bindingi949 – 9491Molybdenum; via amide nitrogen By similarity
Binding sitei951 – 9511Substrate By similarity
Binding sitei1047 – 10471Substrate By similarity
Metal bindingi1116 – 11161Molybdenum; via amide nitrogen By similarity
Active sitei1305 – 13051Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi293 – 3008FAD By similarity
Nucleotide bindingi383 – 3875FAD By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. UDP-N-acetylmuramate dehydrogenase activity Source: InterPro
  3. electron carrier activity Source: InterPro
  4. flavin adenine dinucleotide binding Source: InterPro
  5. iron ion binding Source: InterPro
  6. xanthine dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to reactive oxygen species Source: EnsemblPlants/Gramene
  2. response to water deprivation Source: EnsemblPlants/Gramene
  3. superoxide anion generation Source: EnsemblPlants/Gramene
  4. xanthine metabolic process Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

2Fe-2S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

Enzyme and pathway databases

ReactomeiREACT_223073. Vitamins B6 activation to pyridoxal phosphate.

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine dehydrogenase (EC:1.17.1.4)
Gene namesi
Name:XDH
Ordered Locus Names:Os03g0429800, LOC_Os03g31550
ORF Names:OsJ_11360, OSJNBa0091B22.11
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 3

Organism-specific databases

GrameneiQ6AUV1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: EnsemblPlants/Gramene
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13691369Xanthine dehydrogenase
PRO_0000417459Add
BLAST

Proteomic databases

PRIDEiQ6AUV1.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6AUV1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 106872Fe-2S ferredoxin-type
Add
BLAST
Domaini265 – 450186FAD-binding PCMH-type
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000191197.
KOiK00106.
OMAiCDETFFA.

Family and domain databases

Gene3Di1.10.150.120. 1 hit.
3.10.20.30. 1 hit.
3.30.365.10. 6 hits.
3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.1170.50. 1 hit.
InterProiIPR002888. 2Fe-2S-bd.
IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR000674. Ald_Oxase/Xan_DH_a/b.
IPR016208. Ald_Oxase/xanthine_DH.
IPR008274. AldOxase/xan_DH_Mopterin-bd.
IPR012675. Beta-grasp_dom.
IPR005107. CO_DH_flav_C.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR002346. Mopterin_DH_FAD-bd.
[Graphical view]
PfamiPF01315. Ald_Xan_dh_C. 1 hit.
PF02738. Ald_Xan_dh_C2. 1 hit.
PF03450. CO_deh_flav_C. 1 hit.
PF00941. FAD_binding_5. 1 hit.
PF00111. Fer2. 1 hit.
PF01799. Fer2_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000127. Xanthine_DH. 1 hit.
SMARTiSM01008. Ald_Xan_dh_C. 1 hit.
SM01092. CO_deh_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF47741. SSF47741. 1 hit.
SSF54292. SSF54292. 1 hit.
SSF54665. SSF54665. 1 hit.
SSF55447. SSF55447. 1 hit.
SSF56003. SSF56003. 1 hit.
SSF56176. SSF56176. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS51387. FAD_PCMH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AUV1-1 [UniParc]FASTAAdd to Basket

« Hide

MGSLTRAEEE ETAAAEEWSG EAVVYVNGVR RVLPDGLAHL TLLQYLRDIG     50
LPGTKLGCGE GGCGACTVMV SCYDQTTKKT QHFAINACLA PLYSVEGMHI 100
ITVEGIGNRQ RGLHPIQERL AMAHGSQCGF CTPGFVMSMY ALLRSSEQPP 150
TEEQIEDSLA GNLCRCTGYR PIIDAFRVFS KRDDLLYNNS SLKNADGRPI 200
CPSTGKPCSC GDQKDINGSE SSLLTPTKSY SPCSYNEIDG NAYSEKELIF 250
PPELQLRKVT SLKLNGFNGI RWYRPLKLKQ VLHLKACYPN AKLIIGNSEV 300
GVETKFKNAQ YKVLISVTHV PELHTLKVKE DGIHIGSSVR LAQLQNFLRK 350
VILERDSHEI SSCEAILRQL KWFAGTQIRN VASVGGNICT ASPISDLNPL 400
WMATGATFEI IDVNNNIRTI PAKDFFLGYR KVDLKPDEIL LSVILPWTRP 450
FEFVKEFKQA HRREDDIALV NAGMRVYIRK VEGDWIISDV SIIYGGVAAV 500
SHRASKTETF LTGKKWDYGL LDKTFDLLKE DVVLAENAPG GMVEFRSSLT 550
LSFFFKFFLH VTHEMNIKGF WKDGLHATNL SAIQSFTRPV GVGTQCYELV 600
RQGTAVGQPV VHTSAMLQVT GEAEYTDDTP TPPNTLHAAL VLSTKAHARI 650
LSIDASLAKS SPGFAGLFLS KDVPGANHTG PVIHDEEVFA SDVVTCVGQI 700
VGLVVADTRD NAKAAANKVN IEYSELPAIL SIEEAVKAGS FHPNSKRCLV 750
KGNVEQCFLS GACDRIIEGK VQVGGQEHFY MEPQSTLVWP VDSGNEIHMI 800
SSTQAPQKHQ KYVANVLGLP QSRVVCKTKR IGGGFGGKET RSAIFAAAAS 850
VAAYCLRQPV KLVLDRDIDM MTTGQRHSFL GKYKVGFTDD GKILALDLDV 900
YNNGGHSHDL SLPVLERAMF HSDNVYDIPN VRVNGQVCFT NFPSNTAFRG 950
FGGPQAMLIA ENWIQHMATE LKRSPEEIKE LNFQSEGSVL HYGQLLQNCT 1000
IHSVWDELKV SCNFMEARKA VIDFNNNNRW RKRGIAMVPT KFGISFTTKF 1050
MNQAGALVQV YTDGTVLVTH GGVEMGQGLH TKVAQVAASS FNIPLSSIFI 1100
SETSTDKVPN ATPTAASASS DLYGAAVLDA CQQIMARMEP VASRGNHKSF 1150
AELVLACYLE RIDLSAHGFY ITPDVGFDWV SGKGTPFYYF TYGAAFAEVE 1200
IDTLTGDFHT RTVDIVMDLG CSINPAIDIG QIEGGFIQGL GWAALEELKW 1250
GDDNHKWIRP GHLFTCGPGS YKIPSVNDIP LNFKVSLLKG VLNPKVIHSS 1300
KAVGEPPFFL GSAVLFAIKD AISAARAEEG HFDWFPLDSP ATPERIRMAC 1350
VDSITKKFAS VYYRPKLSV 1369
Length:1,369
Mass (Da):150,227
Last modified:September 13, 2004 - v1
Checksum:i470407521B957EA0
GO

Sequence cautioni

The sequence ABF96752.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1290 – 12901G → D in AK067814. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC114896 Genomic DNA. Translation: AAT81740.1.
DP000009 Genomic DNA. Translation: ABF96751.1.
DP000009 Genomic DNA. Translation: ABF96752.1. Sequence problems.
AP008209 Genomic DNA. Translation: BAF12334.1.
CM000140 Genomic DNA. Translation: EEE59305.1.
AK067814 mRNA. No translation available.
RefSeqiNP_001050420.1. NM_001056955.1.
UniGeneiOs.10786.

Genome annotation databases

EnsemblPlantsiOS03T0429800-01; OS03T0429800-01; OS03G0429800.
OS03T0429800-02; OS03T0429800-02; OS03G0429800.
GeneIDi4333171.
KEGGiosa:4333171.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC114896 Genomic DNA. Translation: AAT81740.1 .
DP000009 Genomic DNA. Translation: ABF96751.1 .
DP000009 Genomic DNA. Translation: ABF96752.1 . Sequence problems.
AP008209 Genomic DNA. Translation: BAF12334.1 .
CM000140 Genomic DNA. Translation: EEE59305.1 .
AK067814 mRNA. No translation available.
RefSeqi NP_001050420.1. NM_001056955.1.
UniGenei Os.10786.

3D structure databases

ProteinModelPortali Q6AUV1.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q6AUV1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS03T0429800-01 ; OS03T0429800-01 ; OS03G0429800 .
OS03T0429800-02 ; OS03T0429800-02 ; OS03G0429800 .
GeneIDi 4333171.
KEGGi osa:4333171.

Organism-specific databases

Gramenei Q6AUV1.

Phylogenomic databases

HOGENOMi HOG000191197.
KOi K00106.
OMAi CDETFFA.

Enzyme and pathway databases

Reactomei REACT_223073. Vitamins B6 activation to pyridoxal phosphate.

Family and domain databases

Gene3Di 1.10.150.120. 1 hit.
3.10.20.30. 1 hit.
3.30.365.10. 6 hits.
3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.1170.50. 1 hit.
InterProi IPR002888. 2Fe-2S-bd.
IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR000674. Ald_Oxase/Xan_DH_a/b.
IPR016208. Ald_Oxase/xanthine_DH.
IPR008274. AldOxase/xan_DH_Mopterin-bd.
IPR012675. Beta-grasp_dom.
IPR005107. CO_DH_flav_C.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR002346. Mopterin_DH_FAD-bd.
[Graphical view ]
Pfami PF01315. Ald_Xan_dh_C. 1 hit.
PF02738. Ald_Xan_dh_C2. 1 hit.
PF03450. CO_deh_flav_C. 1 hit.
PF00941. FAD_binding_5. 1 hit.
PF00111. Fer2. 1 hit.
PF01799. Fer2_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000127. Xanthine_DH. 1 hit.
SMARTi SM01008. Ald_Xan_dh_C. 1 hit.
SM01092. CO_deh_flav_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47741. SSF47741. 1 hit.
SSF54292. SSF54292. 1 hit.
SSF54665. SSF54665. 1 hit.
SSF55447. SSF55447. 1 hit.
SSF56003. SSF56003. 1 hit.
SSF56176. SSF56176. 1 hit.
PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS51387. FAD_PCMH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species."
    The rice chromosome 3 sequencing consortium
    Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S.
    , Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S.
    Genome Res. 15:1284-1291(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  4. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  5. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiXDH_ORYSJ
AccessioniPrimary (citable) accession number: Q6AUV1
Secondary accession number(s): Q10J86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2012
Last sequence update: September 13, 2004
Last modified: September 3, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi