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Q6AUC6 (QSOX1_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sulfhydryl oxidase 1

EC=1.8.3.2
Alternative name(s):
Quiescin-sulfhydryl oxidase 1
Short name=OsQSOX1
Gene names
Name:QSOX1
Ordered Locus Names:Os05g0552500, LOC_Os05g47930
ORF Names:OsJ_19470, OSJNBa0079H23.16
OrganismOryza sativa subsp. japonica (Rice) [Reference proteome]
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins By similarity.

Catalytic activity

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactor

FAD By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Contains 1 ERV/ALR sulfhydryl oxidase domain.

Contains 1 thioredoxin domain.

Sequence caution

The sequence BAF18170.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Cellular componentSecreted
   DomainRedox-active center
Signal
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell redox homeostasis

Inferred from electronic annotation. Source: InterPro

positive regulation of potassium ion transport

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

response to cation stress

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

   Cellular_componentendosome

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

trans-Golgi network

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

   Molecular_functionthiol oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 513483Sulfhydryl oxidase 1
PRO_0000400052

Regions

Domain31 – 174144Thioredoxin
Domain304 – 406103ERV/ALR sulfhydryl oxidase
Nucleotide binding377 – 3848FAD By similarity

Sites

Active site761Nucleophile By similarity
Active site791Nucleophile By similarity
Binding site3091FAD By similarity
Binding site3161FAD By similarity
Binding site3201FAD By similarity
Binding site3501FAD By similarity
Binding site3541FAD By similarity
Binding site4031FAD By similarity
Binding site4061FAD By similarity

Amino acid modifications

Glycosylation511N-linked (GlcNAc...) Potential
Glycosylation1931N-linked (GlcNAc...) Potential
Glycosylation2661N-linked (GlcNAc...) Potential
Disulfide bond76 ↔ 79Redox-active By similarity
Disulfide bond301 ↔ 313 By similarity
Disulfide bond348 ↔ 351 By similarity
Disulfide bond412 ↔ 415 By similarity

Experimental info

Sequence conflict1601R → G in AK121660. Ref.5
Sequence conflict3611S → G in AK121660. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q6AUC6 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: B891D5944EDC38A4

FASTA51357,849
        10         20         30         40         50         60 
MAAAAVARRV VLVLVLAAAS LAAAPRGAAA RSLGGREGPG EVDADAAVDL NATNFDAFLK 

        70         80         90        100        110        120 
ASLEPWAVVE FFAHWCPACR NYKPHYEKVA KLFNGRDAAH PGLILMARVD CASKVNIDLC 

       130        140        150        160        170        180 
NRFSVDHYPF LLWGPPTKFA SAKWDPKQEN NEIKLIDDGR TAERLLKWIN NQMKSSFSLE 

       190        200        210        220        230        240 
DKKYENENML PKNASDPEQI VQAIYDVEEA TAQALQIILE RKTIKPKNRD SLIRFLQILV 

       250        260        270        280        290        300 
ARHPSKRCRR GSAELLINFD DHWSSNLSLS SQEGSKLLES VAEENHWICG KEVPRGYWLF 

       310        320        330        340        350        360 
CRGSKSETRG FSCGLWVLMH SLTVRIGDGE SQSTFTSICD FIHNFFICEE CRKHFYEMCS 

       370        380        390        400        410        420 
SVSAPFRTAR ELSLWLWSTH NKVNMRLMKE EKDMGTGDPL FPKVTWPPNQ LCPSCYRSSK 

       430        440        450        460        470        480 
VTDGAVDWNE DAVYQFLVNY YGKKLVSSYK ETYMESLQQQ EKKIVSEDSS ISNAASVPIG 

       490        500        510 
AALGVAIASC TFGALACFWR AQQKNRKQRK NWN 

« Hide

References

« Hide 'large scale' references
[1]"A fine physical map of the rice chromosome 5."
Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J., Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S., Shaw J.-F., Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y.
Mol. Genet. Genomics 274:337-345(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[2]"The map-based sequence of the rice genome."
International rice genome sequencing project (IRGSP)
Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[3]"The rice annotation project database (RAP-DB): 2008 update."
The rice annotation project (RAP)
Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: cv. Nipponbare.
[4]"The genomes of Oryza sativa: a history of duplications."
Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L. expand/collapse author list , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[5]"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
The rice full-length cDNA consortium
Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Nipponbare.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC129717 Genomic DNA. Translation: AAT85195.1.
AP008211 Genomic DNA. Translation: BAF18170.1. Sequence problems.
CM000142 Genomic DNA. Translation: EEE64618.1.
AK121660 mRNA. No translation available.
RefSeqNP_001056256.1. NM_001062791.1.
UniGeneOs.12118.

3D structure databases

ProteinModelPortalQ6AUC6.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsOS05T0552500-02; OS05T0552500-02; OS05G0552500.
GeneID4339541.
KEGGosa:4339541.

Organism-specific databases

GrameneQ6AUC6.

Phylogenomic databases

eggNOGNOG237986.

Family and domain databases

Gene3D1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProIPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamPF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEPS51324. ERV_ALR. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQSOX1_ORYSJ
AccessionPrimary (citable) accession number: Q6AUC6
Secondary accession number(s): Q0DG53
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: September 13, 2004
Last modified: July 9, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations