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Protein

Sulfhydryl oxidase 1

Gene

QSOX1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins (By similarity).By similarity

Catalytic activityi

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactori

FADPROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei76NucleophileBy similarity1
Active sitei79NucleophileBy similarity1
Binding sitei309FADBy similarity1
Binding sitei316FADBy similarity1
Binding sitei320FADBy similarity1
Binding sitei350FADBy similarity1
Binding sitei354FADBy similarity1
Binding sitei403FADBy similarity1
Binding sitei406FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi377 – 384FADBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-OSA-114608. Platelet degranulation.
R-OSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfhydryl oxidase 1 (EC:1.8.3.2)
Alternative name(s):
Quiescin-sulfhydryl oxidase 1
Short name:
OsQSOX1
Gene namesi
Name:QSOX1
Ordered Locus Names:Os05g0552500, LOC_Os05g47930
ORF Names:OsJ_19470, OSJNBa0079H23.16
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000040005231 – 513Sulfhydryl oxidase 1Add BLAST483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi76 ↔ 79Redox-activePROSITE-ProRule annotation
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi301 ↔ 313PROSITE-ProRule annotation
Disulfide bondi348 ↔ 351PROSITE-ProRule annotation
Disulfide bondi412 ↔ 415PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6AUC6.

Expressioni

Gene expression databases

ExpressionAtlasiQ6AUC6. baseline.
GenevisibleiQ6AUC6. OS.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os05g47930.1.

Structurei

3D structure databases

ProteinModelPortaliQ6AUC6.
SMRiQ6AUC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 174ThioredoxinPROSITE-ProRule annotationAdd BLAST144
Domaini304 – 406ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd BLAST103

Keywords - Domaini

Redox-active center, Signal

Phylogenomic databases

eggNOGiKOG1731. Eukaryota.
ENOG410XVJT. LUCA.
InParanoidiQ6AUC6.
KOiK10758.
OMAiFASAKWD.
OrthoDBiEOG093607HV.

Family and domain databases

Gene3Di1.20.120.310. 1 hit.
InterProiView protein in InterPro
IPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
PfamiView protein in Pfam
PF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEiView protein in PROSITE
PS51324. ERV_ALR. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AUC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAVARRV VLVLVLAAAS LAAAPRGAAA RSLGGREGPG EVDADAAVDL
60 70 80 90 100
NATNFDAFLK ASLEPWAVVE FFAHWCPACR NYKPHYEKVA KLFNGRDAAH
110 120 130 140 150
PGLILMARVD CASKVNIDLC NRFSVDHYPF LLWGPPTKFA SAKWDPKQEN
160 170 180 190 200
NEIKLIDDGR TAERLLKWIN NQMKSSFSLE DKKYENENML PKNASDPEQI
210 220 230 240 250
VQAIYDVEEA TAQALQIILE RKTIKPKNRD SLIRFLQILV ARHPSKRCRR
260 270 280 290 300
GSAELLINFD DHWSSNLSLS SQEGSKLLES VAEENHWICG KEVPRGYWLF
310 320 330 340 350
CRGSKSETRG FSCGLWVLMH SLTVRIGDGE SQSTFTSICD FIHNFFICEE
360 370 380 390 400
CRKHFYEMCS SVSAPFRTAR ELSLWLWSTH NKVNMRLMKE EKDMGTGDPL
410 420 430 440 450
FPKVTWPPNQ LCPSCYRSSK VTDGAVDWNE DAVYQFLVNY YGKKLVSSYK
460 470 480 490 500
ETYMESLQQQ EKKIVSEDSS ISNAASVPIG AALGVAIASC TFGALACFWR
510
AQQKNRKQRK NWN
Length:513
Mass (Da):57,849
Last modified:September 13, 2004 - v1
Checksum:iB891D5944EDC38A4
GO

Sequence cautioni

The sequence BAF18170 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160R → G in AK121660 (PubMed:12869764).Curated1
Sequence conflicti361S → G in AK121660 (PubMed:12869764).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129717 Genomic DNA. Translation: AAT85195.1.
AP008211 Genomic DNA. Translation: BAF18170.1. Sequence problems.
AP014961 Genomic DNA. Translation: BAS95229.1.
CM000142 Genomic DNA. Translation: EEE64618.1.
AK121660 mRNA. No translation available.
RefSeqiXP_015640480.1. XM_015784994.1.
UniGeneiOs.12118.

Genome annotation databases

EnsemblPlantsiOS05T0552500-02; OS05T0552500-02; OS05G0552500.
GeneIDi4339541.
GrameneiOS05T0552500-02; OS05T0552500-02; OS05G0552500.
KEGGiosa:4339541.

Similar proteinsi

Entry informationi

Entry nameiQSOX1_ORYSJ
AccessioniPrimary (citable) accession number: Q6AUC6
Secondary accession number(s): A0A0P0WQM2, Q0DG53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: September 13, 2004
Last modified: August 30, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations