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Q6AUC6

- QSOX1_ORYSJ

UniProt

Q6AUC6 - QSOX1_ORYSJ

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Protein
Sulfhydryl oxidase 1
Gene
QSOX1, Os05g0552500, LOC_Os05g47930, OsJ_19470, OSJNBa0079H23.16
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins By similarity.

Catalytic activityi

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactori

FAD By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei76 – 761Nucleophile By similarity
Active sitei79 – 791Nucleophile By similarity
Binding sitei309 – 3091FAD By similarity
Binding sitei316 – 3161FAD By similarity
Binding sitei320 – 3201FAD By similarity
Binding sitei350 – 3501FAD By similarity
Binding sitei354 – 3541FAD By similarity
Binding sitei403 – 4031FAD By similarity
Binding sitei406 – 4061FAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi377 – 3848FAD By similarity

GO - Molecular functioni

  1. thiol oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
  2. positive regulation of potassium ion transport Source: EnsemblPlants/Gramene
  3. response to cation stress Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfhydryl oxidase 1 (EC:1.8.3.2)
Alternative name(s):
Quiescin-sulfhydryl oxidase 1
Short name:
OsQSOX1
Gene namesi
Name:QSOX1
Ordered Locus Names:Os05g0552500, LOC_Os05g47930
ORF Names:OsJ_19470, OSJNBa0079H23.16
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 5

Organism-specific databases

GrameneiQ6AUC6.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. endosome Source: EnsemblPlants/Gramene
  2. extracellular region Source: UniProtKB-SubCell
  3. trans-Golgi network Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 Reviewed prediction
Add
BLAST
Chaini31 – 513483Sulfhydryl oxidase 1
PRO_0000400052Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi76 ↔ 79Redox-active By similarity
Glycosylationi193 – 1931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi266 – 2661N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi301 ↔ 313 By similarity
Disulfide bondi348 ↔ 351 By similarity
Disulfide bondi412 ↔ 415 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ6AUC6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 174144Thioredoxin
Add
BLAST
Domaini304 – 406103ERV/ALR sulfhydryl oxidase
Add
BLAST

Sequence similaritiesi

Contains 1 thioredoxin domain.

Keywords - Domaini

Redox-active center, Signal

Phylogenomic databases

eggNOGiNOG237986.

Family and domain databases

Gene3Di1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEiPS51324. ERV_ALR. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AUC6-1 [UniParc]FASTAAdd to Basket

« Hide

MAAAAVARRV VLVLVLAAAS LAAAPRGAAA RSLGGREGPG EVDADAAVDL    50
NATNFDAFLK ASLEPWAVVE FFAHWCPACR NYKPHYEKVA KLFNGRDAAH 100
PGLILMARVD CASKVNIDLC NRFSVDHYPF LLWGPPTKFA SAKWDPKQEN 150
NEIKLIDDGR TAERLLKWIN NQMKSSFSLE DKKYENENML PKNASDPEQI 200
VQAIYDVEEA TAQALQIILE RKTIKPKNRD SLIRFLQILV ARHPSKRCRR 250
GSAELLINFD DHWSSNLSLS SQEGSKLLES VAEENHWICG KEVPRGYWLF 300
CRGSKSETRG FSCGLWVLMH SLTVRIGDGE SQSTFTSICD FIHNFFICEE 350
CRKHFYEMCS SVSAPFRTAR ELSLWLWSTH NKVNMRLMKE EKDMGTGDPL 400
FPKVTWPPNQ LCPSCYRSSK VTDGAVDWNE DAVYQFLVNY YGKKLVSSYK 450
ETYMESLQQQ EKKIVSEDSS ISNAASVPIG AALGVAIASC TFGALACFWR 500
AQQKNRKQRK NWN 513
Length:513
Mass (Da):57,849
Last modified:September 13, 2004 - v1
Checksum:iB891D5944EDC38A4
GO

Sequence cautioni

The sequence BAF18170.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti160 – 1601R → G in AK121660. 1 Publication
Sequence conflicti361 – 3611S → G in AK121660. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC129717 Genomic DNA. Translation: AAT85195.1.
AP008211 Genomic DNA. Translation: BAF18170.1. Sequence problems.
CM000142 Genomic DNA. Translation: EEE64618.1.
AK121660 mRNA. No translation available.
RefSeqiNP_001056256.1. NM_001062791.1.
UniGeneiOs.12118.

Genome annotation databases

EnsemblPlantsiOS05T0552500-02; OS05T0552500-02; OS05G0552500.
GeneIDi4339541.
KEGGiosa:4339541.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC129717 Genomic DNA. Translation: AAT85195.1 .
AP008211 Genomic DNA. Translation: BAF18170.1 . Sequence problems.
CM000142 Genomic DNA. Translation: EEE64618.1 .
AK121660 mRNA. No translation available.
RefSeqi NP_001056256.1. NM_001062791.1.
UniGenei Os.12118.

3D structure databases

ProteinModelPortali Q6AUC6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS05T0552500-02 ; OS05T0552500-02 ; OS05G0552500 .
GeneIDi 4339541.
KEGGi osa:4339541.

Organism-specific databases

Gramenei Q6AUC6.

Phylogenomic databases

eggNOGi NOG237986.

Family and domain databases

Gene3Di 1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEi PS51324. ERV_ALR. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  4. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  5. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiQSOX1_ORYSJ
AccessioniPrimary (citable) accession number: Q6AUC6
Secondary accession number(s): Q0DG53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: September 13, 2004
Last modified: July 9, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi