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Q6AUC6

- QSOX1_ORYSJ

UniProt

Q6AUC6 - QSOX1_ORYSJ

Protein

Sulfhydryl oxidase 1

Gene

QSOX1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins By similarity.By similarity

    Catalytic activityi

    2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

    Cofactori

    FAD.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei76 – 761NucleophileBy similarity
    Active sitei79 – 791NucleophileBy similarity
    Binding sitei309 – 3091FADBy similarity
    Binding sitei316 – 3161FADBy similarity
    Binding sitei320 – 3201FADBy similarity
    Binding sitei350 – 3501FADBy similarity
    Binding sitei354 – 3541FADBy similarity
    Binding sitei403 – 4031FADBy similarity
    Binding sitei406 – 4061FADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi377 – 3848FADBy similarity

    GO - Molecular functioni

    1. thiol oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro
    2. positive regulation of potassium ion transport Source: EnsemblPlants/Gramene
    3. response to cation stress Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sulfhydryl oxidase 1 (EC:1.8.3.2)
    Alternative name(s):
    Quiescin-sulfhydryl oxidase 1
    Short name:
    OsQSOX1
    Gene namesi
    Name:QSOX1
    Ordered Locus Names:Os05g0552500, LOC_Os05g47930
    ORF Names:OsJ_19470, OSJNBa0079H23.16
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 5

    Organism-specific databases

    GrameneiQ6AUC6.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. endosome Source: EnsemblPlants/Gramene
    2. extracellular region Source: UniProtKB-SubCell
    3. trans-Golgi network Source: EnsemblPlants/Gramene

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 513483Sulfhydryl oxidase 1PRO_0000400052Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi76 ↔ 79Redox-activePROSITE-ProRule annotation
    Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi301 ↔ 313PROSITE-ProRule annotation
    Disulfide bondi348 ↔ 351PROSITE-ProRule annotation
    Disulfide bondi412 ↔ 415PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AUC6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 174144ThioredoxinPROSITE-ProRule annotationAdd
    BLAST
    Domaini304 – 406103ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ERV/ALR sulfhydryl oxidase domain.PROSITE-ProRule annotation
    Contains 1 thioredoxin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Signal

    Phylogenomic databases

    eggNOGiNOG237986.

    Family and domain databases

    Gene3Di1.20.120.310. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF04777. Evr1_Alr. 1 hit.
    PF00085. Thioredoxin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    SSF69000. SSF69000. 1 hit.
    PROSITEiPS51324. ERV_ALR. 1 hit.
    PS00194. THIOREDOXIN_1. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6AUC6-1 [UniParc]FASTAAdd to Basket

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    MAAAAVARRV VLVLVLAAAS LAAAPRGAAA RSLGGREGPG EVDADAAVDL    50
    NATNFDAFLK ASLEPWAVVE FFAHWCPACR NYKPHYEKVA KLFNGRDAAH 100
    PGLILMARVD CASKVNIDLC NRFSVDHYPF LLWGPPTKFA SAKWDPKQEN 150
    NEIKLIDDGR TAERLLKWIN NQMKSSFSLE DKKYENENML PKNASDPEQI 200
    VQAIYDVEEA TAQALQIILE RKTIKPKNRD SLIRFLQILV ARHPSKRCRR 250
    GSAELLINFD DHWSSNLSLS SQEGSKLLES VAEENHWICG KEVPRGYWLF 300
    CRGSKSETRG FSCGLWVLMH SLTVRIGDGE SQSTFTSICD FIHNFFICEE 350
    CRKHFYEMCS SVSAPFRTAR ELSLWLWSTH NKVNMRLMKE EKDMGTGDPL 400
    FPKVTWPPNQ LCPSCYRSSK VTDGAVDWNE DAVYQFLVNY YGKKLVSSYK 450
    ETYMESLQQQ EKKIVSEDSS ISNAASVPIG AALGVAIASC TFGALACFWR 500
    AQQKNRKQRK NWN 513
    Length:513
    Mass (Da):57,849
    Last modified:September 13, 2004 - v1
    Checksum:iB891D5944EDC38A4
    GO

    Sequence cautioni

    The sequence BAF18170.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti160 – 1601R → G in AK121660. (PubMed:12869764)Curated
    Sequence conflicti361 – 3611S → G in AK121660. (PubMed:12869764)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC129717 Genomic DNA. Translation: AAT85195.1.
    AP008211 Genomic DNA. Translation: BAF18170.1. Sequence problems.
    CM000142 Genomic DNA. Translation: EEE64618.1.
    AK121660 mRNA. No translation available.
    RefSeqiNP_001056256.1. NM_001062791.1.
    UniGeneiOs.12118.

    Genome annotation databases

    EnsemblPlantsiOS05T0552500-02; OS05T0552500-02; OS05G0552500.
    GeneIDi4339541.
    KEGGiosa:4339541.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC129717 Genomic DNA. Translation: AAT85195.1 .
    AP008211 Genomic DNA. Translation: BAF18170.1 . Sequence problems.
    CM000142 Genomic DNA. Translation: EEE64618.1 .
    AK121660 mRNA. No translation available.
    RefSeqi NP_001056256.1. NM_001062791.1.
    UniGenei Os.12118.

    3D structure databases

    ProteinModelPortali Q6AUC6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS05T0552500-02 ; OS05T0552500-02 ; OS05G0552500 .
    GeneIDi 4339541.
    KEGGi osa:4339541.

    Organism-specific databases

    Gramenei Q6AUC6.

    Phylogenomic databases

    eggNOGi NOG237986.

    Family and domain databases

    Gene3Di 1.20.120.310. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR017905. ERV/ALR_sulphydryl_oxidase.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF04777. Evr1_Alr. 1 hit.
    PF00085. Thioredoxin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    SSF69000. SSF69000. 1 hit.
    PROSITEi PS51324. ERV_ALR. 1 hit.
    PS00194. THIOREDOXIN_1. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    3. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    4. "The genomes of Oryza sativa: a history of duplications."
      Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
      , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
      PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    5. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiQSOX1_ORYSJ
    AccessioniPrimary (citable) accession number: Q6AUC6
    Secondary accession number(s): Q0DG53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 2, 2010
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3