Q6AT26 (CESA1_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable cellulose synthase A catalytic subunit 1 [UDP-forming]
EC=2.4.1.12

Alternative name(s):
OsCesA1

Gene names

Name:	CESA1
Ordered Locus Names:	Os05g0176100, LOC_Os05g08370
ORF Names:	OSJNBa0029B02.3, P0617A08.14, OsJ_016545

Organism

Oryza sativa subsp. japonica (Rice)

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	1076 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation By similarity.
Catalytic activity	UDP-glucose + (1,4-beta-D-glucosyl)(n) = UDP + (1,4-beta-D-glucosyl)(n+1).
Cofactor	Binds 2 zinc ions per subunit By similarity.
Pathway	Glycan metabolism; plant cellulose biosynthesis.
Subcellular location	Cell membrane; Multi-pass membrane protein Probable.
Sequence similarities	Belongs to the glycosyltransferase 2 family. Plant cellulose synthase subfamily. Contains 1 RING-type zinc finger.
Sequence caution	The sequence AK100188 differs from that shown. Reason: Erroneous termination at position 388. Translated as Tyr.

Ontologies

Keywords
Biological process	Cell wall biogenesis/degradation Cellulose biosynthesis
Cellular component	Cell membrane Membrane
Domain	Coiled coil Transmembrane Transmembrane helix Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW cellulose biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cellulose synthase (UDP-forming) activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1076	1076	Probable cellulose synthase A catalytic subunit 1 [UDP-forming]		PRO_0000319358
Regions
	Topological domain	1 – 267	267	Cytoplasmic Potential
	Transmembrane	268 – 288	21	Helical; Potential
	Topological domain	289 – 296	8	Extracellular Potential
	Transmembrane	297 – 317	21	Helical; Potential
	Topological domain	318 – 851	534	Cytoplasmic Potential
	Transmembrane	852 – 872	21	Helical; Potential
	Topological domain	873 – 884	12	Extracellular Potential
	Transmembrane	885 – 905	21	Helical; Potential
	Topological domain	906 – 920	15	Cytoplasmic Potential
	Transmembrane	921 – 941	21	Helical; Potential
	Topological domain	942 – 971	30	Extracellular Potential
	Transmembrane	972 – 992	21	Helical; Potential
	Topological domain	993 – 1003	11	Cytoplasmic Potential
	Transmembrane	1004 – 1024	21	Helical; Potential
	Topological domain	1025 – 1033	9	Extracellular Potential
	Transmembrane	1034 – 1054	21	Helical; Potential
	Topological domain	1055 – 1076	22	Cytoplasmic Potential
	Zinc finger	41 – 87	47	RING-type; degenerate
	Coiled coil	446 – 473	28	Potential
Sites
	Active site	392	1	Potential
	Active site	775	1	Potential
	Metal binding	41	1	Zinc 1 By similarity
	Metal binding	44	1	Zinc 1 By similarity
	Metal binding	60	1	Zinc 2 By similarity
	Metal binding	63	1	Zinc 2 By similarity
	Metal binding	68	1	Zinc 1 By similarity
	Metal binding	71	1	Zinc 1 By similarity
	Metal binding	83	1	Zinc 2 By similarity
	Metal binding	86	1	Zinc 2 By similarity
	Binding site	558	1	Substrate Potential
	Binding site	560	1	Substrate Potential
Amino acid modifications
	Glycosylation	948	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	247	1	M → I in AAC39333. Ref.6
	Sequence conflict	565	1	S → N in AAC39333. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Q6AT26 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 6B40F19DAEDF1AEC	FASTA	1,076	121,268
	10 20 30 40 50 60 MAANAGMVAG SRNRNEFVMI RPDGDAPPPA KPGKSVNGQV CQICGDTVGV SATGDVFVAC 70 80 90 100 110 120 NECAFPVCRP CYEYERKEGN QCCPQCKTRY KRHKGSPRVQ GDEEEEDVDD LDNEFNYKHG 130 140 150 160 170 180 NGKGPEWQIQ RQGEDVDLSS SSRHEQHRIP RLTSGQQISG EIPDASPDRH SIRSGTSSYV 190 200 210 220 230 240 DPSVPVPVRI VDPSKDLNSY GINSVDWQER VASWRNKQDK NMMQVANKYP EARGGDMEGT 250 260 270 280 290 300 GSNGEDMQMV DDARLPLSRI VPIPSNQLNL YRIVIILRLI ILMFFFQYRV THPVRDAYGL 310 320 330 340 350 360 WLVSVICEIW FALSWLLDQF PKWYPINRET YLDRLALRYD REGEPSQLAP IDVFVSTVDP 370 380 390 400 410 420 LKEPPLITAN TVLSILAVDY PVDKVSCYVS DDGSAMLTFE ALSETAEFAR KWVPFCKKHN 430 440 450 460 470 480 IEPRAPEFYF AQKIDYLKDK IQPSFVKERR AMKREYEEFK VRINALVAKA QKVPEEGWTM 490 500 510 520 530 540 ADGTAWPGNN PRDHPGMIQV FLGHSGGLDT DGNELPRLVY VSREKRPGFQ HHKKAGAMNA 550 560 570 580 590 600 LIRVSAVLTN GAYLLNVDCD HYFNSSKALR EAMCFMMDPA LGRKTCYVQF PQRFDGIDLH 610 620 630 640 650 660 DRYANRNIVF FDINMKGLDG IQGPVYVGTG CCFNRQALYG YDPVLTEADL EPNIVVKSCC 670 680 690 700 710 720 GGRKKKSKSY MDSKNRMMKR TESSAPIFNM EDIEEGIEGY EDERSVLMSQ KRLEKRFGQS 730 740 750 760 770 780 PIFIASTFMT QGGIPPSTNP ASLLKEAIHV ISCGYEDKTE WGKEIGWIYG SVTEDILTGF 790 800 810 820 830 840 KMHARGWISI YCMPPRPCFK GSAPINLSDR LNQVLRWALG SVEILLSRHC PIWYGYNGRL 850 860 870 880 890 900 KLLERLAYIN TIVYPITSIP LIAYCVLPAI CLLTNKFIIP EISNYAGMFF ILLFASIFAT 910 920 930 940 950 960 GILELRWSGV GIEDWWRNEQ FWVIGGTSAH LFAVFQGLLK VLAGIDTNFT VTSKASDEDG 970 980 990 1000 1010 1020 DFAELYVFKW TSLLIPPTTV LVINLVGMVA GISYAINSGY QSWGPLFGKL FFSIWVILHL 1030 1040 1050 1060 1070 YPFLKGLMGR QNRTPTIVIV WSILLASIFS LLWVKIDPFI SPTQKAVALG QCGVNC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A fine physical map of the rice chromosome 5." Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J., Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S., Shaw J.-F., Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y. Mol. Genet. Genomics 274:337-345(2005) [PubMed: 16261349] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[2]	"The map-based sequence of the rice genome." International rice genome sequencing project (IRGSP) Nature 436:793-800(2005) [PubMed: 16100779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[3]	"The rice annotation project database (RAP-DB): 2008 update." The rice annotation project (RAP) Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed: 18089549] [Abstract] Cited for: GENOME REANNOTATION. Strain: cv. Nipponbare.
[4]	"The genomes of Oryza sativa: a history of duplications." Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L. , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H. PLoS Biol. 3:266-281(2005) [PubMed: 15685292] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[5]	"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice." The rice full-length cDNA consortium Science 301:376-379(2003) [PubMed: 12869764] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Nipponbare.
[6]	"Molecular analysis of cellulose biosynthesis in Arabidopsis." Arioli T., Peng L., Betzner A.S., Burn J., Wittke W., Herth W., Camilleri C., Hoefte H., Plazinski J., Birch R., Cork A., Glover J., Redmond J., Williamson R.E. Science 279:717-720(1998) [PubMed: 9445479] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-583. Strain: cv. Nipponbare.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC135426 Genomic DNA. Translation: AAU44296.1. AC144738 Genomic DNA. Translation: AAT77342.1. AP008211 Genomic DNA. Translation: BAF16702.1. CM000142 Genomic DNA. Translation: EAZ33062.1. AK100188 mRNA. No translation available. AF030052 mRNA. Translation: AAC39333.1.
PIR	T02209.
RefSeq	NP_001054788.1. NM_001061323.1.
UniGene	Os.10183.
3D structure databases
ProteinModelPortal	Q6AT26.
SMR	Q6AT26. Positions 31-99.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6AT26.
Protein family/group databases
CAZy	GT2. Glycosyltransferase Family 2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	LOC_Os05g08370.1; LOC_Os05g08370.1; LOC_Os05g08370.
GeneID	4337958.
KEGG	osa:4337958.
Organism-specific databases
Gramene	Q6AT26.
Phylogenomic databases
GeneTree	EPGT00070000029210.
HOGENOM	HBG744549.
OMA	DIENEFN.
PhylomeDB	Q6AT26.
ProtClustDB	PLN02400.
Family and domain databases
InterPro	IPR005150. Cellulose_synth. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Gene3D	G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
KO	K10999.
Pfam	PF03552. Cellulose_synt. 1 hit. [Graphical view]
SMART	SM00184. RING. 1 hit. [Graphical view]
PROSITE	PS00518. ZF_RING_1. False negative. PS50089. ZF_RING_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CESA1_ORYSJ

Accession

Primary (citable) accession number: Q6AT26
Secondary accession number(s): O48961

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	September 13, 2004
Last modified:	December 14, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program