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Q6AS45 (PGK_DESPS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:DP0101
OrganismDesulfotalea psychrophila (strain LSv54 / DSM 12343) [Complete proteome] [HAMAP]
Taxonomic identifier177439 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_1000096339

Regions

Nucleotide binding349 – 3524ATP By similarity
Region19 – 213Substrate binding By similarity
Region58 – 614Substrate binding By similarity

Sites

Binding site351Substrate By similarity
Binding site1171Substrate By similarity
Binding site1501Substrate By similarity
Binding site2011ATP By similarity
Binding site3231ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AS45 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 1AEAE25CCEB4BE88

FASTA39241,540
        10         20         30         40         50         60 
MKSLRELELA GKRVLVRVDF NVPMDDKQRI TDDIRIRMVL PTLRYVLEQG GRLIICSHMG 

        70         80         90        100        110        120 
RPKGKRVEEY SLAPIARHLA GLLGRDVGIA PDCIGAEVEA QVAALGVGEV LLLQNLRFYG 

       130        140        150        160        170        180 
EETENDAVFA GKLAGLADVY VNDAFAVSHR AHASVVGVAE RVAEKCAGFL LQTEIDYFHK 

       190        200        210        220        230        240 
SMNDPIRPLV ALVGGAKVSS KIGALENMLG KVDKMIIGGA MANTFLMSQG VDVGASKVED 

       250        260        270        280        290        300 
DLLVTARNFL QAAGERGMKV YLPVDFVVAD RFAADAVHKT VPADSVPEGW MALDVGPASS 

       310        320        330        340        350        360 
ILFREALQGA GTIVWNGPMG AFEMDAFAGG TMSLCRDVAA SQALSITGGG DSNAAVKKSG 

       370        380        390 
EADNISYMST GGGAFLQLME GKTLPGVDAL EA 

« Hide

References

[1]"The genome of Desulfotalea psychrophila, a sulfate-reducing bacterium from permanently cold Arctic sediments."
Rabus R., Ruepp A., Frickey T., Rattei T., Fartmann B., Stark M., Bauer M., Zibat A., Lombardot T., Becker I., Amann J., Gellner K., Teeling H., Leuschner W.D., Gloeckner F.-O., Lupas A.N., Amann R., Klenk H.-P.
Environ. Microbiol. 6:887-902(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LSv54 / DSM 12343.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR522870 Genomic DNA. Translation: CAG34830.1.
RefSeqYP_063837.1. NC_006138.1.

3D structure databases

ProteinModelPortalQ6AS45.
SMRQ6AS45. Positions 1-391.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING177439.DP0101.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG34830; CAG34830; DP0101.
GeneID2944599.
KEGGdps:DP0101.
PATRIC21709713. VBIDesPsy67261_0112.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227107.
KOK00927.
OMAFGLADKM.
OrthoDBEOG64N9Z0.

Enzyme and pathway databases

BioCycDPSY177439:GJW5-103-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_DESPS
AccessionPrimary (citable) accession number: Q6AS45
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 13, 2004
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways