Reviewed,
UniProtKB/Swiss-Prot Q6ARX8 (QUEF_DESPS)
Last modified
June 16, 2009.
Version 39.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: NADPH-dependent 7-cyano-7-deazaguanine reductase EC=1.7.1.13 Alternative name(s): 7-cyano-7-carbaguanine reductase PreQ(0) reductase NADPH-dependent nitrile oxidoreductase | ||||
| Gene names |
| ||||
| Organism | Desulfotalea psychrophila [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 84980 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Deltaproteobacteria › Desulfobacterales › Desulfobulbaceae › Desulfotalea |
Protein attributes
| Sequence length | 276 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) By similarity. |
| Catalytic activity | 7-aminomethyl-7-carbaguanine + 2 NADP+ = 7-cyano-7-carbaguanine + 2 NADPH. HAMAP MF_00817 |
| Pathway | tRNA modification; queuosine-tRNA biosynthesis. HAMAP MF_00817 |
| Subcellular location | Cytoplasm Probable. |
| Sequence similarities | Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Queuosine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW queuosine biosynthetic processInferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic processInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | GTP cyclohydrolase I activity Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptorInferred from electronic annotation. Source: HAMAP queuine synthase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 276 | 276 | NADPH-dependent 7-cyano-7-deazaguanine reductase HAMAP MF_00817 | PRO_0000163029 | |||
Sequences
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References
| [1] | "The genome of Desulfotalea psychrophila, a sulfate-reducing bacterium from permanently cold Arctic sediments." Rabus R., Ruepp A., Frickey T., Rattei T., Fartmann B., Stark M., Bauer M., Zibat A., Lombardot T., Becker I., Amann J., Gellner K., Teeling H., Leuschner W.D., Gloeckner F.-O., Lupas A.N., Amann R., Klenk H.-P. Environ. Microbiol. 6:887-902(2004) [PubMed: 15305914] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LSv54 / DSM 12343. |
Cross-references
Sequence databases | |
|---|---|
| CR522870 Genomic DNA. Translation: CAG34897.1. | |
| RefSeq | YP_063904.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2945252. |
| GenomeReviews | Gene locus DP0168 in contig CR522870_GR. |
| KEGG | dps:DP0168. |
| NMPDR | fig|177439.1.peg.168. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q6ARX8. |
| OMA | Q6ARX8. EHNEFHE. |
Enzyme and pathway databases | |
| BioCyc | DPSY177439:DP0168-MON. |
| BRENDA | 1.7.1.13. 280712. |
Family and domain databases | |
| HAMAP | MF_00817. [Tree] |
| InterPro | IPR016428. CN_OxRdtase_NADPH-dep_YqcD. IPR001474. GTP_CycHdrlase_I. [Graphical view] |
| Pfam | PF01227. GTP_cyclohydroI. 1 hit. [Graphical view] |
| PIRSF | PIRSF004750. Nitrile_oxidored_YqcD_prd. 1 hit. |
| TIGRFAMs | TIGR03138. QueF. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | QUEF_DESPS | ||||||||
| Accession | Primary (citable) accession number: Q6ARX8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


