Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Desulfotalea psychrophila (strain LSv54 / DSM 12343)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciDPSY177439:G1GHX-297-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:DP0299
OrganismiDesulfotalea psychrophila (strain LSv54 / DSM 12343)
Taxonomic identifieri177439 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea
Proteomesi
  • UP000000602 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000456451 – 450Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST450

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi177439.DP0299

Structurei

3D structure databases

ProteinModelPortaliQ6ARJ7
SMRiQ6ARJ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q6ARJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYLPHTEEE IQEMLEVVGK ESLDDLFSSV PAECRYQGDI PIPAALTEWQ
60 70 80 90 100
LKDHFAALMS KNRVNQEHKV LIGAGSYDHY VPEILPSLMS RSEFLTAYTP
110 120 130 140 150
YQPEVAQGTL QGIFEYQTLT ARLLGTDAVN ASMYDGASAL AESALMSFRI
160 170 180 190 200
ARKKKTVALS AAIHPHYREV VATYLQATDF TIIELPVDAE GRTDLSSLAG
210 220 230 240 250
IEGLASVAIQ SPNFFGVVED LQGCGEKIHD VDALFISCFS EALAYGLLKS
260 270 280 290 300
PGECGADIIC GEGQSFGLGR SYGGPGVGMM GCRDKLVRNM PGRIVGQTLD
310 320 330 340 350
TKGKRGFVLT LATREQHIRR EKATSNICSN QGICAMTAGM YMATLGGTGI
360 370 380 390 400
RQLARLNYDK AAYLRSELIK LGAKPLFDAP VFNEFALRFP FDFERVREAL
410 420 430 440 450
KEESVVAGLS LEAYYPDLQG AYLFCATETL KKEDIDRIVS SIKKHALQEV
Length:450
Mass (Da):49,373
Last modified:September 13, 2004 - v1
Checksum:i7F0BCA16A29959B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR522870 Genomic DNA Translation: CAG35028.1
RefSeqiWP_011187544.1, NC_006138.1

Genome annotation databases

EnsemblBacteriaiCAG35028; CAG35028; DP0299
KEGGidps:DP0299

Similar proteinsi

Entry informationi

Entry nameiGCSPA_DESPS
AccessioniPrimary (citable) accession number: Q6ARJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2004
Last modified: April 25, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health