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Q6ARJ7 (GCSPA_DESPS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:DP0299
OrganismDesulfotalea psychrophila (strain LSv54 / DSM 12343) [Complete proteome] [HAMAP]
Taxonomic identifier177439 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000045645

Sequences

Sequence LengthMass (Da)Tools
Q6ARJ7 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 7F0BCA16A29959B1

FASTA45049,373
        10         20         30         40         50         60 
MRYLPHTEEE IQEMLEVVGK ESLDDLFSSV PAECRYQGDI PIPAALTEWQ LKDHFAALMS 

        70         80         90        100        110        120 
KNRVNQEHKV LIGAGSYDHY VPEILPSLMS RSEFLTAYTP YQPEVAQGTL QGIFEYQTLT 

       130        140        150        160        170        180 
ARLLGTDAVN ASMYDGASAL AESALMSFRI ARKKKTVALS AAIHPHYREV VATYLQATDF 

       190        200        210        220        230        240 
TIIELPVDAE GRTDLSSLAG IEGLASVAIQ SPNFFGVVED LQGCGEKIHD VDALFISCFS 

       250        260        270        280        290        300 
EALAYGLLKS PGECGADIIC GEGQSFGLGR SYGGPGVGMM GCRDKLVRNM PGRIVGQTLD 

       310        320        330        340        350        360 
TKGKRGFVLT LATREQHIRR EKATSNICSN QGICAMTAGM YMATLGGTGI RQLARLNYDK 

       370        380        390        400        410        420 
AAYLRSELIK LGAKPLFDAP VFNEFALRFP FDFERVREAL KEESVVAGLS LEAYYPDLQG 

       430        440        450 
AYLFCATETL KKEDIDRIVS SIKKHALQEV 

« Hide

References

[1]"The genome of Desulfotalea psychrophila, a sulfate-reducing bacterium from permanently cold Arctic sediments."
Rabus R., Ruepp A., Frickey T., Rattei T., Fartmann B., Stark M., Bauer M., Zibat A., Lombardot T., Becker I., Amann J., Gellner K., Teeling H., Leuschner W.D., Gloeckner F.-O., Lupas A.N., Amann R., Klenk H.-P.
Environ. Microbiol. 6:887-902(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LSv54 / DSM 12343.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR522870 Genomic DNA. Translation: CAG35028.1.
RefSeqYP_064035.1. NC_006138.1.

3D structure databases

ProteinModelPortalQ6ARJ7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING177439.DP0299.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG35028; CAG35028; DP0299.
GeneID2946961.
KEGGdps:DP0299.
PATRIC21710145. VBIDesPsy67261_0327.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMASMYDGST.
OrthoDBEOG6XWV3B.
ProtClustDBPRK00451.

Enzyme and pathway databases

BioCycDPSY177439:GJW5-302-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_DESPS
AccessionPrimary (citable) accession number: Q6ARJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2004
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families