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Q6AQZ6 (THIM_DESPS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:DP0499
OrganismDesulfotalea psychrophila (strain LSv54 / DSM 12343) [Complete proteome] [HAMAP]
Taxonomic identifier177439 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence caution

The sequence CAG35228.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 273273Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000383853

Sites

Binding site471Substrate; via amide nitrogen By similarity
Binding site1231ATP By similarity
Binding site1691ATP By similarity
Binding site1961Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AQZ6 [UniParc].

Last modified September 22, 2009. Version 2.
Checksum: DCF61E401D81E147

FASTA27328,652
        10         20         30         40         50         60 
MSNISLTAAE NLQQIRENKP LIHNITNFVV MNYTANVLLA TGASPVMAHA QNEVEEMVAF 

        70         80         90        100        110        120 
AGSLVLNIGT LSESWVSSML MASQRANTLK TPIILDPVGS GATAFRTASA KRIIAEAKVS 

       130        140        150        160        170        180 
VIRGNASEIL SLGSEQSNTR GVDTSQSVSD AAQTASLLAR ELDTILAITG PTDLVTDGRR 

       190        200        210        220        230        240 
VFNVDNGHPL MPYVTGTGCS ATAVVGAFAA VDRDYLRAAT TALAFFGLAG EMAGKAATGP 

       250        260        270 
GSFMIHLLDA LYNMSPEQLE KGCRIKESSA TRS 

« Hide

References

[1]"The genome of Desulfotalea psychrophila, a sulfate-reducing bacterium from permanently cold Arctic sediments."
Rabus R., Ruepp A., Frickey T., Rattei T., Fartmann B., Stark M., Bauer M., Zibat A., Lombardot T., Becker I., Amann J., Gellner K., Teeling H., Leuschner W.D., Gloeckner F.-O., Lupas A.N., Amann R., Klenk H.-P.
Environ. Microbiol. 6:887-902(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LSv54 / DSM 12343.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR522870 Genomic DNA. Translation: CAG35228.1. Different initiation.
RefSeqYP_064235.1. NC_006138.1.

3D structure databases

ProteinModelPortalQ6AQZ6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING177439.DP0499.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG35228; CAG35228; DP0499.
GeneID2946386.
KEGGdps:DP0499.
PATRIC21710575. VBIDesPsy67261_0540.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMASPVMAHA.
OrthoDBEOG628F8M.
ProtClustDBCLSK2523293.

Enzyme and pathway databases

BioCycDPSY177439:GJW5-504-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_DESPS
AccessionPrimary (citable) accession number: Q6AQZ6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 22, 2009
Last modified: February 19, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways