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Protein

Acetate kinase

Gene

ackA

Organism
Desulfotalea psychrophila (strain LSv54 / DSM 12343)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (DP0558)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7MagnesiumUniRule annotation1
Binding sitei14ATPUniRule annotation1
Binding sitei98SubstrateUniRule annotation1
Active sitei155Proton donor/acceptorUniRule annotation1
Sitei187Transition state stabilizerUniRule annotation1
Sitei248Transition state stabilizerUniRule annotation1
Metal bindingi391MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi215 – 219ATPUniRule annotation5
Nucleotide bindingi289 – 291ATPUniRule annotation3
Nucleotide bindingi337 – 341ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:DP0559
OrganismiDesulfotalea psychrophila (strain LSv54 / DSM 12343)
Taxonomic identifieri177439 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea
Proteomesi
  • UP000000602 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001075551 – 405Acetate kinaseAdd BLAST405

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi177439.DP0559.

Structurei

3D structure databases

ProteinModelPortaliQ6AQT5.
SMRiQ6AQT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6H. Bacteria.
COG0282. LUCA.
HOGENOMiHOG000288398.
KOiK00925.
OMAiFMMQKEN.
OrthoDBiPOG091H02K4.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiView protein in InterPro
IPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiView protein in Pfam
PF00871. Acetate_kinase. 1 hit.
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiView protein in PROSITE
PS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AQT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILIINSGS SSIKFQLIDM SDESVLASGL VERIGETDTT EKNINCTFHP
60 70 80 90 100
GTDKKHKIEI CQTVADHRQG MLAAIELLGD KEQAVMSDLS EIDAVGHRIV
110 120 130 140 150
HGGETMYQPV VVDEKVIAEI TAAIPLAPLH NPGHLDGIKV AQELFTEVPH
160 170 180 190 200
VTVFDTAFFQ TIPPHAHIYA LPYELYTKHR IRRYGAHGTS HKFVTNECAK
210 220 230 240 250
LLEKPVEECN LITVHLGNGS SMSAVEGGKA IDTSMGVTPL EGLVMGTRSG
260 270 280 290 300
DIDPAIMAFL NRNLGMSIEE IDHMLNKESG LKGICGMNDM RDIHAAADAG
310 320 330 340 350
NELAELAVGI QTYRIRKYIG SYMAALGQVD AIVFTAGIGE NDDIVRAKSL
360 370 380 390 400
EKLENLGVIL DKKLNAQRSK EPFCISTPES KIQVWVIPTN EELAIARETK

AVVNA
Length:405
Mass (Da):44,129
Last modified:September 13, 2004 - v1
Checksum:iED790BCB5559D715
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR522870 Genomic DNA. Translation: CAG35288.1.
RefSeqiWP_011187804.1. NC_006138.1.

Genome annotation databases

EnsemblBacteriaiCAG35288; CAG35288; DP0559.
KEGGidps:DP0559.

Similar proteinsi

Entry informationi

Entry nameiACKA_DESPS
AccessioniPrimary (citable) accession number: Q6AQT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: September 13, 2004
Last modified: June 7, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families