Reviewed, UniProtKB/Swiss-Prot Q6AQ79 (KDSA_DESPS)

Names and origin

Protein names

Recommended name:
    2-dehydro-3-deoxyphosphooctonate aldolase
    EC=2.5.1.55
Alternative name(s):
    Phospho-2-dehydro-3-deoxyoctonate aldolase
    3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase
    KDO-8-phosphate synthetase
      Short name=KDO 8-P synthase
      Short name=KDOPS

Gene names

Name:	kdsA
Ordered Locus Names:	DP0765

Organism

Desulfotalea psychrophila [Complete proteome] [HAMAP]

Taxonomic identifier

84980 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfobacterales › Desulfobulbaceae › Desulfotalea

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. HAMAP MF_00056
Pathway	Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3. HAMAP MF_00056 Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00056
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the kdsA family.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-deoxy-8-phosphooctulonate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	2-dehydro-3-deoxyphosphooctonate aldolase HAMAP MF_00056		PRO_0000187122

Sequences

	Sequence		Length	Mass (Da)
	Q6AQ79-1 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 0525AF71D4BCB8E2	FASTA	280	29,725
	10 20 30 40 50 60 MTVVTPVAVA QPNGSDILVG SGQPLLLIGG PCSLESEQLG REVAETVSKI CKKLGISYVF 70 80 90 100 110 120 KASFDKANRT SISSYRGPGL KKGLASLARI REDLQVPVIS DIHDISQVGP AAEVLDIIQI 130 140 150 160 170 180 PAFLCRQTDL LVAAAKSGKP VNVKKGQFVS PWDMENAIGK LRDAGSDKVM LVERGACFGY 190 200 210 220 230 240 NNLVVDMRSL PVMRSFNCPV IYDATHSVQL PGGAGGSSSG QREFIEPLSK AAIAAGIDGL 250 260 270 280 FMEIHPDPDK ALCDGPNSIA LDQVEELLTK LVKVRAAVEE

References

[1]

"The genome of Desulfotalea psychrophila, a sulfate-reducing bacterium from permanently cold Arctic sediments." Rabus R., Ruepp A., Frickey T., Rattei T., Fartmann B., Stark M., Bauer M., Zibat A., Lombardot T., Becker I., Amann J., Gellner K., Teeling H., Leuschner W.D., Gloeckner F.-O., Lupas A.N., Amann R., Klenk H.-P. Environ. Microbiol. 6:887-902(2004) [PubMed: 15305914] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LSv54 / DSM 12343.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR522870 Genomic DNA. Translation: CAG35494.1.
RefSeq	YP_064501.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2945548.
GenomeReviews	Gene locus DP0765 in contig CR522870_GR.
KEGG	dps:DP0765.
NMPDR	fig|177439.1.peg.765.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6AQ79.
OMA	VYKTSFD.
Enzyme and pathway databases
BioCyc	DPSY177439:DP0765-MON.
BRENDA	2.5.1.55. 280712.
Family and domain databases
HAMAP	MF_00056. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006269. KDO8P_synthase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR21057:SF2. KDO8P_synthase. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01362. KDO8P_synth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KDSA_DESPS

Accession

Primary (citable) accession number: Q6AQ79

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	September 13, 2004
Last modified:	November 3, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)