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Q6AQ48 (G6PI_DESPS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:DP0796
OrganismDesulfotalea psychrophila (strain LSv54 / DSM 12343) [Complete proteome] [HAMAP]
Taxonomic identifier177439 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea

Protein attributes

Sequence length534 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Sequence caution

The sequence CAG35525.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 534534Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180638

Sites

Active site3561Proton donor By similarity
Active site3871 By similarity
Active site5021 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AQ48 [UniParc].

Last modified March 29, 2005. Version 2.
Checksum: 658C7A34EC605102

FASTA53458,681
        10         20         30         40         50         60 
MFASYKSIQE TCAFEKLSEL AQSPYDLTQP GALQADNRLQ RYQVAGQAFK LFYATEQVDD 

        70         80         90        100        110        120 
RVLAGLQAVA DECQLVSQYR AMRTGAVMNK IDGFVSENRR VLHTATRDLF SGEPAEASMN 

       130        140        150        160        170        180 
SRAKRELEKL SHFLDALDAG EIVNEAGEAF TTIVQVGIGG SDLGPRAVYE ALKSYTIVGR 

       190        200        210        220        230        240 
RAAFISNVDP DDVSMALADL DLGKTIFNIV SKSGSTLETV TNEAFVRRAL LENGYDSARH 

       250        260        270        280        290        300 
CISITGEGSP MDDPDSYLAS FYLYDCIGGR YSTTSMVGCV LLGFTLGFEQ VMAFLRGAAN 

       310        320        330        340        350        360 
MDNSADEVDI LKNIPLLMAL IGIWNRNFLD LSSLAIIPYS QALYRFPAHL QQCDMESNGK 

       370        380        390        400        410        420 
SVDRQGRAVQ GKTGPIIWGE TGSNSQHAFF QHIYQGTSPV PIEFIGFSES QRGKDIEVQG 

       430        440        450        460        470        480 
CTSQQKLLAN LFAQMVALAC GKKDQNLNKF FAGNRPSCLL FAKKLTPYVM GSLLACYEAK 

       490        500        510        520        530 
IVFQGFAWNI NSFDQEGVQL GKELAKRFLR EIGGEEEGFH GIESAFLNEV QRGV 

« Hide

References

[1]"The genome of Desulfotalea psychrophila, a sulfate-reducing bacterium from permanently cold Arctic sediments."
Rabus R., Ruepp A., Frickey T., Rattei T., Fartmann B., Stark M., Bauer M., Zibat A., Lombardot T., Becker I., Amann J., Gellner K., Teeling H., Leuschner W.D., Gloeckner F.-O., Lupas A.N., Amann R., Klenk H.-P.
Environ. Microbiol. 6:887-902(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LSv54 / DSM 12343.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR522870 Genomic DNA. Translation: CAG35525.1. Different initiation.
RefSeqYP_064532.1. NC_006138.1.

3D structure databases

ProteinModelPortalQ6AQ48.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING177439.DP0796.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG35525; CAG35525; DP0796.
GeneID2945586.
KEGGdps:DP0796.
PATRIC21711259. VBIDesPsy67261_0861.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000261370.
KOK01810.
OMALKMHFVS.
OrthoDBEOG64R61J.
ProtClustDBPRK14095.

Enzyme and pathway databases

BioCycDPSY177439:GJW5-823-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_DESPS
AccessionPrimary (citable) accession number: Q6AQ48
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: February 19, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways