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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Desulfotalea psychrophila (strain LSv54 / DSM 12343)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei356 – 3561Proton donorUniRule annotation
Active sitei387 – 3871UniRule annotation
Active sitei502 – 5021UniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciDPSY177439:GJW5-823-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:DP0796
OrganismiDesulfotalea psychrophila (strain LSv54 / DSM 12343)
Taxonomic identifieri177439 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea
ProteomesiUP000000602 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 534534Glucose-6-phosphate isomerasePRO_0000180638Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi177439.DP0796.

Structurei

3D structure databases

ProteinModelPortaliQ6AQ48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiFELANDC.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AQ48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFASYKSIQE TCAFEKLSEL AQSPYDLTQP GALQADNRLQ RYQVAGQAFK
60 70 80 90 100
LFYATEQVDD RVLAGLQAVA DECQLVSQYR AMRTGAVMNK IDGFVSENRR
110 120 130 140 150
VLHTATRDLF SGEPAEASMN SRAKRELEKL SHFLDALDAG EIVNEAGEAF
160 170 180 190 200
TTIVQVGIGG SDLGPRAVYE ALKSYTIVGR RAAFISNVDP DDVSMALADL
210 220 230 240 250
DLGKTIFNIV SKSGSTLETV TNEAFVRRAL LENGYDSARH CISITGEGSP
260 270 280 290 300
MDDPDSYLAS FYLYDCIGGR YSTTSMVGCV LLGFTLGFEQ VMAFLRGAAN
310 320 330 340 350
MDNSADEVDI LKNIPLLMAL IGIWNRNFLD LSSLAIIPYS QALYRFPAHL
360 370 380 390 400
QQCDMESNGK SVDRQGRAVQ GKTGPIIWGE TGSNSQHAFF QHIYQGTSPV
410 420 430 440 450
PIEFIGFSES QRGKDIEVQG CTSQQKLLAN LFAQMVALAC GKKDQNLNKF
460 470 480 490 500
FAGNRPSCLL FAKKLTPYVM GSLLACYEAK IVFQGFAWNI NSFDQEGVQL
510 520 530
GKELAKRFLR EIGGEEEGFH GIESAFLNEV QRGV
Length:534
Mass (Da):58,681
Last modified:March 28, 2005 - v2
Checksum:i658C7A34EC605102
GO

Sequence cautioni

The sequence CAG35525.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR522870 Genomic DNA. Translation: CAG35525.1. Different initiation.
RefSeqiYP_064532.1. NC_006138.1.

Genome annotation databases

EnsemblBacteriaiCAG35525; CAG35525; DP0796.
KEGGidps:DP0796.
PATRICi21711259. VBIDesPsy67261_0861.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR522870 Genomic DNA. Translation: CAG35525.1. Different initiation.
RefSeqiYP_064532.1. NC_006138.1.

3D structure databases

ProteinModelPortaliQ6AQ48.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi177439.DP0796.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG35525; CAG35525; DP0796.
KEGGidps:DP0796.
PATRICi21711259. VBIDesPsy67261_0861.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiFELANDC.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciDPSY177439:GJW5-823-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LSv54 / DSM 12343.

Entry informationi

Entry nameiG6PI_DESPS
AccessioniPrimary (citable) accession number: Q6AQ48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2005
Last sequence update: March 28, 2005
Last modified: March 31, 2015
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.