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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Desulfotalea psychrophila (strain LSv54 / DSM 12343)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei356Proton donorUniRule annotation1
Active sitei387UniRule annotation1
Active sitei502UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciDPSY177439:G1GHX-812-MONOMER
UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:DP0796
OrganismiDesulfotalea psychrophila (strain LSv54 / DSM 12343)
Taxonomic identifieri177439 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea
Proteomesi
  • UP000000602 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001806381 – 534Glucose-6-phosphate isomeraseAdd BLAST534

Proteomic databases

PRIDEiQ6AQ48

Interactioni

Protein-protein interaction databases

STRINGi177439.DP0796

Structurei

3D structure databases

ProteinModelPortaliQ6AQ48
SMRiQ6AQ48
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QP8 Bacteria
COG0166 LUCA
HOGENOMiHOG000261370
KOiK01810
OMAiTNSQHAF
OrthoDBiPOG091H04C3

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.10, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q6AQ48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFASYKSIQE TCAFEKLSEL AQSPYDLTQP GALQADNRLQ RYQVAGQAFK
60 70 80 90 100
LFYATEQVDD RVLAGLQAVA DECQLVSQYR AMRTGAVMNK IDGFVSENRR
110 120 130 140 150
VLHTATRDLF SGEPAEASMN SRAKRELEKL SHFLDALDAG EIVNEAGEAF
160 170 180 190 200
TTIVQVGIGG SDLGPRAVYE ALKSYTIVGR RAAFISNVDP DDVSMALADL
210 220 230 240 250
DLGKTIFNIV SKSGSTLETV TNEAFVRRAL LENGYDSARH CISITGEGSP
260 270 280 290 300
MDDPDSYLAS FYLYDCIGGR YSTTSMVGCV LLGFTLGFEQ VMAFLRGAAN
310 320 330 340 350
MDNSADEVDI LKNIPLLMAL IGIWNRNFLD LSSLAIIPYS QALYRFPAHL
360 370 380 390 400
QQCDMESNGK SVDRQGRAVQ GKTGPIIWGE TGSNSQHAFF QHIYQGTSPV
410 420 430 440 450
PIEFIGFSES QRGKDIEVQG CTSQQKLLAN LFAQMVALAC GKKDQNLNKF
460 470 480 490 500
FAGNRPSCLL FAKKLTPYVM GSLLACYEAK IVFQGFAWNI NSFDQEGVQL
510 520 530
GKELAKRFLR EIGGEEEGFH GIESAFLNEV QRGV
Length:534
Mass (Da):58,681
Last modified:March 29, 2005 - v2
Checksum:i658C7A34EC605102
GO

Sequence cautioni

The sequence CAG35525 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR522870 Genomic DNA Translation: CAG35525.1 Different initiation.
RefSeqiWP_041277607.1, NC_006138.1

Genome annotation databases

EnsemblBacteriaiCAG35525; CAG35525; DP0796
KEGGidps:DP0796

Similar proteinsi

Entry informationi

Entry nameiG6PI_DESPS
AccessioniPrimary (citable) accession number: Q6AQ48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: May 23, 2018
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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