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Q6APB0

- HEMH_DESPS

UniProt

Q6APB0 - HEMH_DESPS

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Protein
Ferrochelatase
Gene
hemH, DP1085
Organism
Desulfotalea psychrophila (strain LSv54 / DSM 12343)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the ferrous insertion into protoporphyrin IX By similarity.UniRule annotation

Catalytic activityi

Protoheme + 2 H+ = protoporphyrin + Fe2+.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi194 – 1941Iron By similarity
Metal bindingi272 – 2721Iron By similarity

GO - Molecular functioni

  1. ferrochelatase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. heme biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciDPSY177439:GJW5-1118-MONOMER.
UniPathwayiUPA00252; UER00325.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferrochelatase (EC:4.99.1.1)
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene namesi
Name:hemH
Ordered Locus Names:DP1085
OrganismiDesulfotalea psychrophila (strain LSv54 / DSM 12343)
Taxonomic identifieri177439 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea
ProteomesiUP000000602: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320FerrochelataseUniRule annotation
PRO_0000175137Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi177439.DP1085.

Structurei

3D structure databases

ProteinModelPortaliQ6APB0.

Family & Domainsi

Sequence similaritiesi

Belongs to the ferrochelatase family.

Phylogenomic databases

eggNOGiCOG0276.
HOGENOMiHOG000060727.
KOiK01772.
OMAiKFVAFMI.
OrthoDBiEOG6XHC5H.

Family and domain databases

HAMAPiMF_00323. Ferrochelatase.
InterProiIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.
PROSITEiPS00534. FERROCHELATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6APB0-1 [UniParc]FASTAAdd to Basket

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MQNIPTGVIL LNMGGPTQTK DVRPFLYNLF SDREIIPLGP RLMQKPLAWL    50
IAKRRAPKSA ATYERIGGGS PLKQITEAQA EALEKSLQAH GNFTVTYAMR 100
YWPPYCDEAL DYLLSKGVER LVALSLYPHY SKATTGSSLT QLHKTLKKKN 150
ISLPLTEIPS WPKQRDYIAA IAANIKKGLA TFHGEKTEIV YSAHSLPTSF 200
IEAGDPYVEH TKQSIGAIEE ITGKRGRLCF QSKSGPVEWL EPSTPDVLIQ 250
LAQEGVKNIL MVPISFVSDH VETLYEIDIL YKKQAKKLGM RLTSCPSLNT 300
QEQFITGLRQ LVLESSVNSD 320
Length:320
Mass (Da):35,657
Last modified:September 13, 2004 - v1
Checksum:iC5D1C691CFD8239E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR522870 Genomic DNA. Translation: CAG35814.1.
RefSeqiYP_064821.1. NC_006138.1.

Genome annotation databases

EnsemblBacteriaiCAG35814; CAG35814; DP1085.
GeneIDi2947271.
KEGGidps:DP1085.
PATRICi21711879. VBIDesPsy67261_1164.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR522870 Genomic DNA. Translation: CAG35814.1 .
RefSeqi YP_064821.1. NC_006138.1.

3D structure databases

ProteinModelPortali Q6APB0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 177439.DP1085.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG35814 ; CAG35814 ; DP1085 .
GeneIDi 2947271.
KEGGi dps:DP1085.
PATRICi 21711879. VBIDesPsy67261_1164.

Phylogenomic databases

eggNOGi COG0276.
HOGENOMi HOG000060727.
KOi K01772.
OMAi KFVAFMI.
OrthoDBi EOG6XHC5H.

Enzyme and pathway databases

UniPathwayi UPA00252 ; UER00325 .
BioCyci DPSY177439:GJW5-1118-MONOMER.

Family and domain databases

HAMAPi MF_00323. Ferrochelatase.
InterProi IPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view ]
PANTHERi PTHR11108. PTHR11108. 1 hit.
Pfami PF00762. Ferrochelatase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00109. hemH. 1 hit.
PROSITEi PS00534. FERROCHELATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LSv54 / DSM 12343.

Entry informationi

Entry nameiHEMH_DESPS
AccessioniPrimary (citable) accession number: Q6APB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: September 13, 2004
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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