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Q6APB0 (HEMH_DESPS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferrochelatase

EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:DP1085
OrganismDesulfotalea psychrophila (strain LSv54 / DSM 12343) [Complete proteome] [HAMAP]
Taxonomic identifier177439 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP-Rule MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP-Rule MF_00323

Pathway

Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP-Rule MF_00323

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionferrochelatase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Ferrochelatase HAMAP-Rule MF_00323
PRO_0000175137

Sites

Metal binding1941Iron By similarity
Metal binding2721Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6APB0 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: C5D1C691CFD8239E

FASTA32035,657
        10         20         30         40         50         60 
MQNIPTGVIL LNMGGPTQTK DVRPFLYNLF SDREIIPLGP RLMQKPLAWL IAKRRAPKSA 

        70         80         90        100        110        120 
ATYERIGGGS PLKQITEAQA EALEKSLQAH GNFTVTYAMR YWPPYCDEAL DYLLSKGVER 

       130        140        150        160        170        180 
LVALSLYPHY SKATTGSSLT QLHKTLKKKN ISLPLTEIPS WPKQRDYIAA IAANIKKGLA 

       190        200        210        220        230        240 
TFHGEKTEIV YSAHSLPTSF IEAGDPYVEH TKQSIGAIEE ITGKRGRLCF QSKSGPVEWL 

       250        260        270        280        290        300 
EPSTPDVLIQ LAQEGVKNIL MVPISFVSDH VETLYEIDIL YKKQAKKLGM RLTSCPSLNT 

       310        320 
QEQFITGLRQ LVLESSVNSD 

« Hide

References

[1]"The genome of Desulfotalea psychrophila, a sulfate-reducing bacterium from permanently cold Arctic sediments."
Rabus R., Ruepp A., Frickey T., Rattei T., Fartmann B., Stark M., Bauer M., Zibat A., Lombardot T., Becker I., Amann J., Gellner K., Teeling H., Leuschner W.D., Gloeckner F.-O., Lupas A.N., Amann R., Klenk H.-P.
Environ. Microbiol. 6:887-902(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LSv54 / DSM 12343.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR522870 Genomic DNA. Translation: CAG35814.1.
RefSeqYP_064821.1. NC_006138.1.

3D structure databases

ProteinModelPortalQ6APB0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING177439.DP1085.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG35814; CAG35814; DP1085.
GeneID2947271.
KEGGdps:DP1085.
PATRIC21711879. VBIDesPsy67261_1164.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHOG000060727.
KOK01772.
OMAKFVAFMI.
OrthoDBEOG6XHC5H.

Enzyme and pathway databases

BioCycDPSY177439:GJW5-1118-MONOMER.
UniPathwayUPA00252; UER00325.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
PANTHERPTHR11108. PTHR11108. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. hemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_DESPS
AccessionPrimary (citable) accession number: Q6APB0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: September 13, 2004
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways