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Q6APB0

- HEMH_DESPS

UniProt

Q6APB0 - HEMH_DESPS

Protein

Ferrochelatase

Gene

hemH

Organism
Desulfotalea psychrophila (strain LSv54 / DSM 12343)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the ferrous insertion into protoporphyrin IX.UniRule annotation

    Catalytic activityi

    Protoheme + 2 H+ = protoporphyrin + Fe2+.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi194 – 1941IronUniRule annotation
    Metal bindingi272 – 2721IronUniRule annotation

    GO - Molecular functioni

    1. ferrochelatase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. heme biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Heme biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciDPSY177439:GJW5-1118-MONOMER.
    UniPathwayiUPA00252; UER00325.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FerrochelataseUniRule annotation (EC:4.99.1.1UniRule annotation)
    Alternative name(s):
    Heme synthaseUniRule annotation
    Protoheme ferro-lyaseUniRule annotation
    Gene namesi
    Name:hemHUniRule annotation
    Ordered Locus Names:DP1085
    OrganismiDesulfotalea psychrophila (strain LSv54 / DSM 12343)
    Taxonomic identifieri177439 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea
    ProteomesiUP000000602: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320FerrochelatasePRO_0000175137Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi177439.DP1085.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6APB0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ferrochelatase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0276.
    HOGENOMiHOG000060727.
    KOiK01772.
    OMAiKFVAFMI.
    OrthoDBiEOG6XHC5H.

    Family and domain databases

    HAMAPiMF_00323. Ferrochelatase.
    InterProiIPR001015. Ferrochelatase.
    IPR019772. Ferrochelatase_AS.
    [Graphical view]
    PANTHERiPTHR11108. PTHR11108. 1 hit.
    PfamiPF00762. Ferrochelatase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00109. hemH. 1 hit.
    PROSITEiPS00534. FERROCHELATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6APB0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQNIPTGVIL LNMGGPTQTK DVRPFLYNLF SDREIIPLGP RLMQKPLAWL    50
    IAKRRAPKSA ATYERIGGGS PLKQITEAQA EALEKSLQAH GNFTVTYAMR 100
    YWPPYCDEAL DYLLSKGVER LVALSLYPHY SKATTGSSLT QLHKTLKKKN 150
    ISLPLTEIPS WPKQRDYIAA IAANIKKGLA TFHGEKTEIV YSAHSLPTSF 200
    IEAGDPYVEH TKQSIGAIEE ITGKRGRLCF QSKSGPVEWL EPSTPDVLIQ 250
    LAQEGVKNIL MVPISFVSDH VETLYEIDIL YKKQAKKLGM RLTSCPSLNT 300
    QEQFITGLRQ LVLESSVNSD 320
    Length:320
    Mass (Da):35,657
    Last modified:September 13, 2004 - v1
    Checksum:iC5D1C691CFD8239E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR522870 Genomic DNA. Translation: CAG35814.1.
    RefSeqiYP_064821.1. NC_006138.1.

    Genome annotation databases

    EnsemblBacteriaiCAG35814; CAG35814; DP1085.
    GeneIDi2947271.
    KEGGidps:DP1085.
    PATRICi21711879. VBIDesPsy67261_1164.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR522870 Genomic DNA. Translation: CAG35814.1 .
    RefSeqi YP_064821.1. NC_006138.1.

    3D structure databases

    ProteinModelPortali Q6APB0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 177439.DP1085.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG35814 ; CAG35814 ; DP1085 .
    GeneIDi 2947271.
    KEGGi dps:DP1085.
    PATRICi 21711879. VBIDesPsy67261_1164.

    Phylogenomic databases

    eggNOGi COG0276.
    HOGENOMi HOG000060727.
    KOi K01772.
    OMAi KFVAFMI.
    OrthoDBi EOG6XHC5H.

    Enzyme and pathway databases

    UniPathwayi UPA00252 ; UER00325 .
    BioCyci DPSY177439:GJW5-1118-MONOMER.

    Family and domain databases

    HAMAPi MF_00323. Ferrochelatase.
    InterProi IPR001015. Ferrochelatase.
    IPR019772. Ferrochelatase_AS.
    [Graphical view ]
    PANTHERi PTHR11108. PTHR11108. 1 hit.
    Pfami PF00762. Ferrochelatase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00109. hemH. 1 hit.
    PROSITEi PS00534. FERROCHELATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LSv54 / DSM 12343.

    Entry informationi

    Entry nameiHEMH_DESPS
    AccessioniPrimary (citable) accession number: Q6APB0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3