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Q6APB0 (HEMH_DESPS) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:DP1085
OrganismDesulfotalea psychrophila [Complete proteome] [HAMAP]
Taxonomic identifier84980 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Desulfobacterales › Desulfobulbaceae › Desulfotalea

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Ferrochelatase HAMAP MF_00323
PRO_0000175137

Sites

Metal binding1941Iron By similarity
Metal binding2721Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6APB0 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: C5D1C691CFD8239E

FASTA32035,657
        10         20         30         40         50         60 
MQNIPTGVIL LNMGGPTQTK DVRPFLYNLF SDREIIPLGP RLMQKPLAWL IAKRRAPKSA 

        70         80         90        100        110        120 
ATYERIGGGS PLKQITEAQA EALEKSLQAH GNFTVTYAMR YWPPYCDEAL DYLLSKGVER 

       130        140        150        160        170        180 
LVALSLYPHY SKATTGSSLT QLHKTLKKKN ISLPLTEIPS WPKQRDYIAA IAANIKKGLA 

       190        200        210        220        230        240 
TFHGEKTEIV YSAHSLPTSF IEAGDPYVEH TKQSIGAIEE ITGKRGRLCF QSKSGPVEWL 

       250        260        270        280        290        300 
EPSTPDVLIQ LAQEGVKNIL MVPISFVSDH VETLYEIDIL YKKQAKKLGM RLTSCPSLNT 

       310        320 
QEQFITGLRQ LVLESSVNSD

« Hide

References

[1]"The genome of Desulfotalea psychrophila, a sulfate-reducing bacterium from permanently cold Arctic sediments."
Rabus R., Ruepp A., Frickey T., Rattei T., Fartmann B., Stark M., Bauer M., Zibat A., Lombardot T., Becker I., Amann J., Gellner K., Teeling H., Leuschner W.D., Gloeckner F.-O., Lupas A.N., Amann R., Klenk H.-P.
Environ. Microbiol. 6:887-902(2004) [PubMed: 15305914] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LSv54 / DSM 12343.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR522870 Genomic DNA. Translation: CAG35814.1.
RefSeqYP_064821.1. NC_006138.1.

3D structure databases

ProteinModelPortalQ6APB0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2947271.
GenomeReviewsGene locus DP1085 in contig CR522870_GR.
KEGGdps:DP1085.
NMPDRfig|177439.1.peg.1085.
PATRIC21711879. VBIDesPsy67261_1164.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMASWYDEPK.
ProtClustDBCLSK2764751.

Enzyme and pathway databases

BioCycDPSY177439:DP1085-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_DESPS
AccessionPrimary (citable) accession number: Q6APB0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: September 13, 2004
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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