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Q6ANR3

- HISX_DESPS

UniProt

Q6ANR3 - HISX_DESPS

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Desulfotalea psychrophila (strain LSv54 / DSM 12343)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei242 – 2421SubstrateUniRule annotation
    Metal bindingi264 – 2641ZincUniRule annotation
    Binding sitei264 – 2641SubstrateUniRule annotation
    Metal bindingi267 – 2671ZincUniRule annotation
    Binding sitei267 – 2671SubstrateUniRule annotation
    Active sitei332 – 3321Proton acceptorUniRule annotation
    Active sitei333 – 3331Proton acceptorUniRule annotation
    Binding sitei333 – 3331SubstrateUniRule annotation
    Metal bindingi366 – 3661ZincUniRule annotation
    Binding sitei366 – 3661SubstrateUniRule annotation
    Binding sitei420 – 4201SubstrateUniRule annotation
    Metal bindingi425 – 4251ZincUniRule annotation
    Binding sitei425 – 4251SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciDPSY177439:GJW5-1322-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:DP1282
    OrganismiDesulfotalea psychrophila (strain LSv54 / DSM 12343)
    Taxonomic identifieri177439 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea
    ProteomesiUP000000602: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434Histidinol dehydrogenasePRO_0000135767Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi177439.DP1282.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ANR3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiQKSLHAV.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6ANR3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLIEPKMIGS SEGQALLESL LNRFQIGDSG CQSAVEDILT AVRQEGDAAV    50
    VKYCRRFDCP DMTASALAVT AAEIAAAYEL VDAAFLETLA AAIERIHSFH 100
    EREMEDSWMQ TREDGTIVGR LVRPVDSAGL YVPGGTGGST PLVSSVLMNG 150
    IPAGIAGVTT RVMVTPPGKD GKISPHLLVA ATEIGITEIY KAGSAWGIAA 200
    LAYGTATIPR VDVIVGPGNQ FVTEAKRLVS GMVRIDMIAG PSEVLIVADE 250
    TADPVYIAAD MLAQAEHDPQ ALSILLTTDR QVAEAVPAEI ERQLKTLSRA 300
    EIAEKSIVDR AVILVVADIE EAIGLANDIA IEHLELMIVD PWAQVPHIRH 350
    AGAIFLGSHT PEAAGDYFAG PNHVLPTMGT ARFASALGVE TFLKKSSIIS 400
    YSQTALQNDA EHIQRLANLE GLTAHANSVA VRVK 434
    Length:434
    Mass (Da):45,998
    Last modified:September 13, 2004 - v1
    Checksum:i6282B79273F5C856
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR522870 Genomic DNA. Translation: CAG36011.1.
    RefSeqiYP_065018.1. NC_006138.1.

    Genome annotation databases

    EnsemblBacteriaiCAG36011; CAG36011; DP1282.
    GeneIDi2945672.
    KEGGidps:DP1282.
    PATRICi21712341. VBIDesPsy67261_1387.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR522870 Genomic DNA. Translation: CAG36011.1 .
    RefSeqi YP_065018.1. NC_006138.1.

    3D structure databases

    ProteinModelPortali Q6ANR3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 177439.DP1282.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG36011 ; CAG36011 ; DP1282 .
    GeneIDi 2945672.
    KEGGi dps:DP1282.
    PATRICi 21712341. VBIDesPsy67261_1387.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi QKSLHAV.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci DPSY177439:GJW5-1322-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LSv54 / DSM 12343.

    Entry informationi

    Entry nameiHISX_DESPS
    AccessioniPrimary (citable) accession number: Q6ANR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3