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Q6ANR3

- HISX_DESPS

UniProt

Q6ANR3 - HISX_DESPS

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Protein
Histidinol dehydrogenase
Gene
hisD, DP1282
Organism
Desulfotalea psychrophila (strain LSv54 / DSM 12343)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei242 – 2421Substrate By similarity
Metal bindingi264 – 2641Zinc By similarity
Binding sitei264 – 2641Substrate By similarity
Metal bindingi267 – 2671Zinc By similarity
Binding sitei267 – 2671Substrate By similarity
Active sitei332 – 3321Proton acceptor By similarity
Active sitei333 – 3331Proton acceptor By similarity
Binding sitei333 – 3331Substrate By similarity
Metal bindingi366 – 3661Zinc By similarity
Binding sitei366 – 3661Substrate By similarity
Binding sitei420 – 4201Substrate By similarity
Metal bindingi425 – 4251Zinc By similarity
Binding sitei425 – 4251Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciDPSY177439:GJW5-1322-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:DP1282
OrganismiDesulfotalea psychrophila (strain LSv54 / DSM 12343)
Taxonomic identifieri177439 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea
ProteomesiUP000000602: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Histidinol dehydrogenaseUniRule annotation
PRO_0000135767Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi177439.DP1282.

Structurei

3D structure databases

ProteinModelPortaliQ6ANR3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiQKSLHAV.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ANR3-1 [UniParc]FASTAAdd to Basket

« Hide

MLIEPKMIGS SEGQALLESL LNRFQIGDSG CQSAVEDILT AVRQEGDAAV    50
VKYCRRFDCP DMTASALAVT AAEIAAAYEL VDAAFLETLA AAIERIHSFH 100
EREMEDSWMQ TREDGTIVGR LVRPVDSAGL YVPGGTGGST PLVSSVLMNG 150
IPAGIAGVTT RVMVTPPGKD GKISPHLLVA ATEIGITEIY KAGSAWGIAA 200
LAYGTATIPR VDVIVGPGNQ FVTEAKRLVS GMVRIDMIAG PSEVLIVADE 250
TADPVYIAAD MLAQAEHDPQ ALSILLTTDR QVAEAVPAEI ERQLKTLSRA 300
EIAEKSIVDR AVILVVADIE EAIGLANDIA IEHLELMIVD PWAQVPHIRH 350
AGAIFLGSHT PEAAGDYFAG PNHVLPTMGT ARFASALGVE TFLKKSSIIS 400
YSQTALQNDA EHIQRLANLE GLTAHANSVA VRVK 434
Length:434
Mass (Da):45,998
Last modified:September 13, 2004 - v1
Checksum:i6282B79273F5C856
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR522870 Genomic DNA. Translation: CAG36011.1.
RefSeqiYP_065018.1. NC_006138.1.

Genome annotation databases

EnsemblBacteriaiCAG36011; CAG36011; DP1282.
GeneIDi2945672.
KEGGidps:DP1282.
PATRICi21712341. VBIDesPsy67261_1387.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR522870 Genomic DNA. Translation: CAG36011.1 .
RefSeqi YP_065018.1. NC_006138.1.

3D structure databases

ProteinModelPortali Q6ANR3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 177439.DP1282.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG36011 ; CAG36011 ; DP1282 .
GeneIDi 2945672.
KEGGi dps:DP1282.
PATRICi 21712341. VBIDesPsy67261_1387.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi QKSLHAV.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci DPSY177439:GJW5-1322-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LSv54 / DSM 12343.

Entry informationi

Entry nameiHISX_DESPS
AccessioniPrimary (citable) accession number: Q6ANR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: September 13, 2004
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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