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Q6ANL4 (SYN_DESPS) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Asparagine--tRNA ligase
EC=6.1.1.22
Alternative name(s):
Asparaginyl-tRNA synthetase
Short name=AsnRS
Gene names
Name:asnS
Ordered Locus Names:DP1331
OrganismDesulfotalea psychrophila [Complete proteome] [HAMAP]
Taxonomic identifier84980 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Desulfobacterales › Desulfobulbaceae › Desulfotalea

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn). HAMAP MF_00534

Subunit structure

Homodimer By similarity. HAMAP MF_00534

Subcellular location

Cytoplasm HAMAP MF_00534.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processasparaginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

asparagine-tRNA ligase activity

Inferred from electronic annotation. Source: EC

nucleic acid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 449449Asparagine--tRNA ligase HAMAP MF_00534
PRO_0000176404

Sequences

Sequence LengthMass (Da)Tools
Q6ANL4 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 9A656B8E8DA61E72

FASTA44950,214
        10         20         30         40         50         60 
MRQRITELLV AKAEEQVVTV AGWIRTRRDT GDFSFLEVND GSTLINMQVI ADKSLGNYEE 

        70         80         90        100        110        120 
EVKKLSTGCS VMVEGVLKES PAKGQSVEVH ASSVTVVGWA DPETYPLQKK RHSLEFLREI 

       130        140        150        160        170        180 
SHLRPRTNAI SAVARVRSRL SYAVHNFFQE KGFTQVHTPI ITTSDCEGAG EMFQVAATGK 

       190        200        210        220        230        240 
DGHFFGAPAG LTVSGQLQAE VYATALGDVY TFGPTFRAEN SNTSRHLAEF WMIEPEMAFC 

       250        260        270        280        290        300 
DLQGDMEVAE EMLKYVLADV LEHCVTDMNL FDKFISKGII ERLQSVLAHD FARVTYTEAV 

       310        320        330        340        350        360 
DQLLASGQKF DFAVKWGIDL QSEHERYLTE QVYKRPLIVT DYPAAIKPFY MRMNEDGKTV 

       370        380        390        400        410        420 
AAMDILVPGI GELVGGSQRE ERYDLLAERM EAAGLDLEEY GWYLDLRKYG TVPHAGFGLG 

       430        440 
FERLVQFVTG MANIREVIPF PRTPGFAPC

« Hide

References

[1]"The genome of Desulfotalea psychrophila, a sulfate-reducing bacterium from permanently cold Arctic sediments."
Rabus R., Ruepp A., Frickey T., Rattei T., Fartmann B., Stark M., Bauer M., Zibat A., Lombardot T., Becker I., Amann J., Gellner K., Teeling H., Leuschner W.D., Gloeckner F.-O., Lupas A.N., Amann R., Klenk H.-P.
Environ. Microbiol. 6:887-902(2004) [PubMed: 15305914] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LSv54 / DSM 12343.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR522870 Genomic DNA. Translation: CAG36060.1.
RefSeqYP_065067.1. NC_006138.1.

3D structure databases

ProteinModelPortalQ6ANL4.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2945640.
GenomeReviewsGene locus DP1331 in contig CR522870_GR.
KEGGdps:DP1331.
NMPDRfig|177439.1.peg.1331.
PATRIC21712453. VBIDesPsy67261_1436.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG745843.
OMAAIHRFFH.
ProtClustDBPRK03932.

Enzyme and pathway databases

BioCycDPSY177439:DP1331-MONOMER.

Family and domain databases

HAMAPMF_00534. Asn_tRNA_synth.
[Tree]
InterProIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR004522. Asn-tRNA-synth_IIb.
IPR002312. Asp/Asn-tRNA-synth_IIb.
IPR012340. NA-bd_OB-fold.
IPR016027. NA-bd_OB-fold-like.
IPR004365. NA-bd_OB_tRNA-helicase.
[Graphical view]
Gene3DG3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KOK01893.
PANTHERPTHR22594. aa-tRNA-synt_II. 1 hit.
PTHR22594:SF6. PTHR22594:SF6. 1 hit.
PfamPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti. 1 hit.
[Graphical view]
PRINTSPR01042. TRNASYNTHASP.
SUPFAMSSF50249. Nucleic_acid_OB. 1 hit.
TIGRFAMsTIGR00457. AsnS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYN_DESPS
AccessionPrimary (citable) accession number: Q6ANL4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: September 13, 2004
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

SIMILARITY comments

Index of protein domains and families

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