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Q6AMT5

- GCH4_DESPS

UniProt

Q6AMT5 - GCH4_DESPS

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Protein
GTP cyclohydrolase FolE2
Gene
folE2, DP1611
Organism
Desulfotalea psychrophila (strain LSv54 / DSM 12343)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei137 – 1371May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciDPSY177439:GJW5-1664-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:DP1611
OrganismiDesulfotalea psychrophila (strain LSv54 / DSM 12343)
Taxonomic identifieri177439 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea
ProteomesiUP000000602: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251GTP cyclohydrolase FolE2UniRule annotation
PRO_0000147708Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi177439.DP1611.

Structurei

3D structure databases

ProteinModelPortaliQ6AMT5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiNQRAEVT.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AMT5-1 [UniParc]FASTAAdd to Basket

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MSKKQSTICQ KVGIADLEIP IILGQKDGKL QHSIASCKIT ATIKETLKGD    50
ISGEVQRLLP SFTKEIEPKS WHRLLEEFKE NIGVEKITLS LSCPFFVSKK 100
APVSELRGLM EYNCTFSAST GESGITTSLY VPVTTLCPCS KEISDGGAHN 150
QRAEAIFRVE MKEHLWLEDL IQLVEESASC QVYSVLKRPD EKYVTEKAFD 200
NPMFVEDVVR KIAVRAGEHP LIHAFSISVE SFESIHKHNA YAYVNSEDLN 250
L 251
Length:251
Mass (Da):28,093
Last modified:September 13, 2004 - v1
Checksum:iF4266DE5B6EDF84C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR522870 Genomic DNA. Translation: CAG36340.1.
RefSeqiYP_065347.1. NC_006138.1.

Genome annotation databases

EnsemblBacteriaiCAG36340; CAG36340; DP1611.
GeneIDi2946179.
KEGGidps:DP1611.
PATRICi21713070. VBIDesPsy67261_1739.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR522870 Genomic DNA. Translation: CAG36340.1 .
RefSeqi YP_065347.1. NC_006138.1.

3D structure databases

ProteinModelPortali Q6AMT5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 177439.DP1611.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG36340 ; CAG36340 ; DP1611 .
GeneIDi 2946179.
KEGGi dps:DP1611.
PATRICi 21713070. VBIDesPsy67261_1739.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi NQRAEVT.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci DPSY177439:GJW5-1664-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LSv54 / DSM 12343.

Entry informationi

Entry nameiGCH4_DESPS
AccessioniPrimary (citable) accession number: Q6AMT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: September 13, 2004
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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