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Q6ALW0

- LPXB_DESPS

UniProt

Q6ALW0 - LPXB_DESPS

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, DP1936
Organism
Desulfotalea psychrophila (strain LSv54 / DSM 12343)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciDPSY177439:GJW5-2000-MONOMER.
UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:DP1936
OrganismiDesulfotalea psychrophila (strain LSv54 / DSM 12343)
Taxonomic identifieri177439 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea
ProteomesiUP000000602: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 386386Lipid-A-disaccharide synthaseUniRule annotation
PRO_0000255177Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi177439.DP1936.

Structurei

3D structure databases

ProteinModelPortaliQ6ALW0.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiIARMLVN.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6ALW0-1 [UniParc]FASTAAdd to Basket

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MDKQKRETGS EIMVVTGEAS GDIHGANLVR ALKEKDSSLS FSGMGGPELA    50
SLGVEILYDA KKISVVGLVE VFSHLPSIFA AKKILQRRLK NKPPALLIII 100
DLPDFNLMLA KKAKALGIPV FYYITPQVWA WRSGRIKTIG ERTDQLGVIL 150
PFEEEFFRQR GQAASYVGHP LLDNVSIKLS REEFLTKHRI GPAAKYVGLL 200
PGSREKEISA LLPDFLRAAK RLQDECSEKI SFLLPIAATI DREQLLENGL 250
AEYQDLLDIH VISEDRYELM ACCDAVVAAS GTVTLELAIL EVPMLVVYRT 300
SPISYWVGRK LVKIEFFSLV NLIAGREVVT ELLQDEVTPE RISIEIKELL 350
YGAKGVAVGK GLREVHGLLG EAGASAKAAD LALSMI 386
Length:386
Mass (Da):42,466
Last modified:September 13, 2004 - v1
Checksum:i34559C7C93F5DAA3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR522870 Genomic DNA. Translation: CAG36665.1.
RefSeqiWP_011189177.1. NC_006138.1.
YP_065672.1. NC_006138.1.

Genome annotation databases

EnsemblBacteriaiCAG36665; CAG36665; DP1936.
GeneIDi2944865.
KEGGidps:DP1936.
PATRICi21713822. VBIDesPsy67261_2104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR522870 Genomic DNA. Translation: CAG36665.1 .
RefSeqi WP_011189177.1. NC_006138.1.
YP_065672.1. NC_006138.1.

3D structure databases

ProteinModelPortali Q6ALW0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 177439.DP1936.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG36665 ; CAG36665 ; DP1936 .
GeneIDi 2944865.
KEGGi dps:DP1936.
PATRICi 21713822. VBIDesPsy67261_2104.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi IARMLVN.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci DPSY177439:GJW5-2000-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LSv54 / DSM 12343.

Entry informationi

Entry nameiLPXB_DESPS
AccessioniPrimary (citable) accession number: Q6ALW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 13, 2004
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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