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Q6ALW0

- LPXB_DESPS

UniProt

Q6ALW0 - LPXB_DESPS

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Desulfotalea psychrophila (strain LSv54 / DSM 12343)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciDPSY177439:GJW5-2000-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:DP1936
    OrganismiDesulfotalea psychrophila (strain LSv54 / DSM 12343)
    Taxonomic identifieri177439 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea
    ProteomesiUP000000602: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 386386Lipid-A-disaccharide synthasePRO_0000255177Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi177439.DP1936.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ALW0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018004.
    KOiK00748.
    OMAiIARMLVN.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6ALW0-1 [UniParc]FASTAAdd to Basket

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    MDKQKRETGS EIMVVTGEAS GDIHGANLVR ALKEKDSSLS FSGMGGPELA    50
    SLGVEILYDA KKISVVGLVE VFSHLPSIFA AKKILQRRLK NKPPALLIII 100
    DLPDFNLMLA KKAKALGIPV FYYITPQVWA WRSGRIKTIG ERTDQLGVIL 150
    PFEEEFFRQR GQAASYVGHP LLDNVSIKLS REEFLTKHRI GPAAKYVGLL 200
    PGSREKEISA LLPDFLRAAK RLQDECSEKI SFLLPIAATI DREQLLENGL 250
    AEYQDLLDIH VISEDRYELM ACCDAVVAAS GTVTLELAIL EVPMLVVYRT 300
    SPISYWVGRK LVKIEFFSLV NLIAGREVVT ELLQDEVTPE RISIEIKELL 350
    YGAKGVAVGK GLREVHGLLG EAGASAKAAD LALSMI 386
    Length:386
    Mass (Da):42,466
    Last modified:September 13, 2004 - v1
    Checksum:i34559C7C93F5DAA3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR522870 Genomic DNA. Translation: CAG36665.1.
    RefSeqiWP_011189177.1. NC_006138.1.
    YP_065672.1. NC_006138.1.

    Genome annotation databases

    EnsemblBacteriaiCAG36665; CAG36665; DP1936.
    GeneIDi2944865.
    KEGGidps:DP1936.
    PATRICi21713822. VBIDesPsy67261_2104.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR522870 Genomic DNA. Translation: CAG36665.1 .
    RefSeqi WP_011189177.1. NC_006138.1.
    YP_065672.1. NC_006138.1.

    3D structure databases

    ProteinModelPortali Q6ALW0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 177439.DP1936.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG36665 ; CAG36665 ; DP1936 .
    GeneIDi 2944865.
    KEGGi dps:DP1936.
    PATRICi 21713822. VBIDesPsy67261_2104.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018004.
    KOi K00748.
    OMAi IARMLVN.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci DPSY177439:GJW5-2000-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LSv54 / DSM 12343.

    Entry informationi

    Entry nameiLPXB_DESPS
    AccessioniPrimary (citable) accession number: Q6ALW0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3