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Q6AL19

- FTHS_DESPS

UniProt

Q6AL19 - FTHS_DESPS

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Desulfotalea psychrophila (strain LSv54 / DSM 12343)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi44 – 518ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDPSY177439:GJW5-2293-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:DP2227
    OrganismiDesulfotalea psychrophila (strain LSv54 / DSM 12343)
    Taxonomic identifieri177439 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea
    ProteomesiUP000000602: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 557557Formate--tetrahydrofolate ligasePRO_0000199346Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi177439.DP2227.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AL19.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiIANSVSM.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6AL19-1 [UniParc]FASTAAdd to Basket

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    MDLTKEEILP YGHHVAKLDY RKILDRCADR PDGKYIDVTA ITPTPLGEGK    50
    STSVMGLVQG LGKRDKSVVG AIRQPSGGPT MNIKGSAAGG GRSQCIPLNE 100
    FSLGLTGDIN SIMNAHNLGM VALTARMQHE ANYTDAQLAQ RNLKRLDIHP 150
    KKIQFSWIID FCAQALRNIT IGIGGKMDGP TIQSSFAIAV SSELMAILAI 200
    ANDLADMRAR IAKVVVAYDK QDRPITTADL EVDGAMTAWM VQAINPNLMQ 250
    TLEGQPVLVH AGPFANIAIG QSSVIADRVG LKIAGYNVTE SGFGADIGFE 300
    KFWNLKCRFS GNKPNCAVIV ATIRALKCHG GAPIPVPGKP MPEEYAKENV 350
    GWVEEGCKNL LHHINTVKKA GINPVVCINA FYTDRPNEIK AVKRICEHAG 400
    ARVAVSTHWE HGGDGALEFA DAVIDACEEK NDFKFLYELD TPLEKRIELI 450
    AKEVYGADGV SYTPEARTKL TQLAKDPEMA ELGTCMVKTH LSLSHDPKLK 500
    GVPKGWTLPI RDILTYKGAG FVVPVAGAIS LMPGTGSDPA YRRVDVDLQT 550
    GRVKGVF 557
    Length:557
    Mass (Da):60,188
    Last modified:September 13, 2004 - v1
    Checksum:i1D4E4CE5390AEF03
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR522870 Genomic DNA. Translation: CAG36956.1.
    RefSeqiYP_065963.1. NC_006138.1.

    Genome annotation databases

    EnsemblBacteriaiCAG36956; CAG36956; DP2227.
    GeneIDi2945163.
    KEGGidps:DP2227.
    PATRICi21714496. VBIDesPsy67261_2439.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR522870 Genomic DNA. Translation: CAG36956.1 .
    RefSeqi YP_065963.1. NC_006138.1.

    3D structure databases

    ProteinModelPortali Q6AL19.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 177439.DP2227.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG36956 ; CAG36956 ; DP2227 .
    GeneIDi 2945163.
    KEGGi dps:DP2227.
    PATRICi 21714496. VBIDesPsy67261_2439.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi IANSVSM.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci DPSY177439:GJW5-2293-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LSv54 / DSM 12343.

    Entry informationi

    Entry nameiFTHS_DESPS
    AccessioniPrimary (citable) accession number: Q6AL19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3