Q6AL19 (FTHS_DESPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase
EC=6.3.4.3

Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS

Gene names

Name:	fhs
Ordered Locus Names:	DP2227

Organism

Desulfotalea psychrophila [Complete proteome] [HAMAP]

Taxonomic identifier

84980 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfobacterales › Desulfobulbaceae › Desulfotalea

Protein attributes

Sequence length	557 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 557	557	Formate--tetrahydrofolate ligase HAMAP MF_01543		PRO_0000199346
Regions
	Nucleotide binding	44 – 51	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6AL19 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 1D4E4CE5390AEF03	FASTA	557	60,188
	10 20 30 40 50 60 MDLTKEEILP YGHHVAKLDY RKILDRCADR PDGKYIDVTA ITPTPLGEGK STSVMGLVQG 70 80 90 100 110 120 LGKRDKSVVG AIRQPSGGPT MNIKGSAAGG GRSQCIPLNE FSLGLTGDIN SIMNAHNLGM 130 140 150 160 170 180 VALTARMQHE ANYTDAQLAQ RNLKRLDIHP KKIQFSWIID FCAQALRNIT IGIGGKMDGP 190 200 210 220 230 240 TIQSSFAIAV SSELMAILAI ANDLADMRAR IAKVVVAYDK QDRPITTADL EVDGAMTAWM 250 260 270 280 290 300 VQAINPNLMQ TLEGQPVLVH AGPFANIAIG QSSVIADRVG LKIAGYNVTE SGFGADIGFE 310 320 330 340 350 360 KFWNLKCRFS GNKPNCAVIV ATIRALKCHG GAPIPVPGKP MPEEYAKENV GWVEEGCKNL 370 380 390 400 410 420 LHHINTVKKA GINPVVCINA FYTDRPNEIK AVKRICEHAG ARVAVSTHWE HGGDGALEFA 430 440 450 460 470 480 DAVIDACEEK NDFKFLYELD TPLEKRIELI AKEVYGADGV SYTPEARTKL TQLAKDPEMA 490 500 510 520 530 540 ELGTCMVKTH LSLSHDPKLK GVPKGWTLPI RDILTYKGAG FVVPVAGAIS LMPGTGSDPA 550 YRRVDVDLQT GRVKGVF

References

[1]

"The genome of Desulfotalea psychrophila, a sulfate-reducing bacterium from permanently cold Arctic sediments." Rabus R., Ruepp A., Frickey T., Rattei T., Fartmann B., Stark M., Bauer M., Zibat A., Lombardot T., Becker I., Amann J., Gellner K., Teeling H., Leuschner W.D., Gloeckner F.-O., Lupas A.N., Amann R., Klenk H.-P. Environ. Microbiol. 6:887-902(2004) [PubMed: 15305914] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LSv54 / DSM 12343.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR522870 Genomic DNA. Translation: CAG36956.1.
RefSeq	YP_065963.1. NC_006138.1.
3D structure databases
ProteinModelPortal	Q6AL19.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2945163.
GenomeReviews	Gene locus DP2227 in contig CR522870_GR.
KEGG	dps:DP2227.
NMPDR	fig|177439.1.peg.2227.
PATRIC	21714496. VBIDesPsy67261_2439.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG677721.
OMA	NHLHHGN.
ProtClustDB	PRK13507.
Enzyme and pathway databases
BioCyc	DPSY177439:DP2227-MONOMER.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHS_DESPS

Accession

Primary (citable) accession number: Q6AL19

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	September 13, 2004
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program