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Q6AL19

- FTHS_DESPS

UniProt

Q6AL19 - FTHS_DESPS

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Desulfotalea psychrophila (strain LSv54 / DSM 12343)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi44 – 518ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDPSY177439:GJW5-2293-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:DP2227
OrganismiDesulfotalea psychrophila (strain LSv54 / DSM 12343)
Taxonomic identifieri177439 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea
ProteomesiUP000000602: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Formate--tetrahydrofolate ligasePRO_0000199346Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi177439.DP2227.

Structurei

3D structure databases

ProteinModelPortaliQ6AL19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AL19-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLTKEEILP YGHHVAKLDY RKILDRCADR PDGKYIDVTA ITPTPLGEGK
60 70 80 90 100
STSVMGLVQG LGKRDKSVVG AIRQPSGGPT MNIKGSAAGG GRSQCIPLNE
110 120 130 140 150
FSLGLTGDIN SIMNAHNLGM VALTARMQHE ANYTDAQLAQ RNLKRLDIHP
160 170 180 190 200
KKIQFSWIID FCAQALRNIT IGIGGKMDGP TIQSSFAIAV SSELMAILAI
210 220 230 240 250
ANDLADMRAR IAKVVVAYDK QDRPITTADL EVDGAMTAWM VQAINPNLMQ
260 270 280 290 300
TLEGQPVLVH AGPFANIAIG QSSVIADRVG LKIAGYNVTE SGFGADIGFE
310 320 330 340 350
KFWNLKCRFS GNKPNCAVIV ATIRALKCHG GAPIPVPGKP MPEEYAKENV
360 370 380 390 400
GWVEEGCKNL LHHINTVKKA GINPVVCINA FYTDRPNEIK AVKRICEHAG
410 420 430 440 450
ARVAVSTHWE HGGDGALEFA DAVIDACEEK NDFKFLYELD TPLEKRIELI
460 470 480 490 500
AKEVYGADGV SYTPEARTKL TQLAKDPEMA ELGTCMVKTH LSLSHDPKLK
510 520 530 540 550
GVPKGWTLPI RDILTYKGAG FVVPVAGAIS LMPGTGSDPA YRRVDVDLQT

GRVKGVF
Length:557
Mass (Da):60,188
Last modified:September 13, 2004 - v1
Checksum:i1D4E4CE5390AEF03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR522870 Genomic DNA. Translation: CAG36956.1.
RefSeqiYP_065963.1. NC_006138.1.

Genome annotation databases

EnsemblBacteriaiCAG36956; CAG36956; DP2227.
GeneIDi2945163.
KEGGidps:DP2227.
PATRICi21714496. VBIDesPsy67261_2439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR522870 Genomic DNA. Translation: CAG36956.1 .
RefSeqi YP_065963.1. NC_006138.1.

3D structure databases

ProteinModelPortali Q6AL19.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 177439.DP2227.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG36956 ; CAG36956 ; DP2227 .
GeneIDi 2945163.
KEGGi dps:DP2227.
PATRICi 21714496. VBIDesPsy67261_2439.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IANSVSM.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci DPSY177439:GJW5-2293-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LSv54 / DSM 12343.

Entry informationi

Entry nameiFTHS_DESPS
AccessioniPrimary (citable) accession number: Q6AL19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: September 13, 2004
Last modified: October 1, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3