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Q6AL19 (FTHS_DESPS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:DP2227
OrganismDesulfotalea psychrophila (strain LSv54 / DSM 12343) [Complete proteome] [HAMAP]
Taxonomic identifier177439 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 557557Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199346

Regions

Nucleotide binding44 – 518ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AL19 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 1D4E4CE5390AEF03

FASTA55760,188
        10         20         30         40         50         60 
MDLTKEEILP YGHHVAKLDY RKILDRCADR PDGKYIDVTA ITPTPLGEGK STSVMGLVQG 

        70         80         90        100        110        120 
LGKRDKSVVG AIRQPSGGPT MNIKGSAAGG GRSQCIPLNE FSLGLTGDIN SIMNAHNLGM 

       130        140        150        160        170        180 
VALTARMQHE ANYTDAQLAQ RNLKRLDIHP KKIQFSWIID FCAQALRNIT IGIGGKMDGP 

       190        200        210        220        230        240 
TIQSSFAIAV SSELMAILAI ANDLADMRAR IAKVVVAYDK QDRPITTADL EVDGAMTAWM 

       250        260        270        280        290        300 
VQAINPNLMQ TLEGQPVLVH AGPFANIAIG QSSVIADRVG LKIAGYNVTE SGFGADIGFE 

       310        320        330        340        350        360 
KFWNLKCRFS GNKPNCAVIV ATIRALKCHG GAPIPVPGKP MPEEYAKENV GWVEEGCKNL 

       370        380        390        400        410        420 
LHHINTVKKA GINPVVCINA FYTDRPNEIK AVKRICEHAG ARVAVSTHWE HGGDGALEFA 

       430        440        450        460        470        480 
DAVIDACEEK NDFKFLYELD TPLEKRIELI AKEVYGADGV SYTPEARTKL TQLAKDPEMA 

       490        500        510        520        530        540 
ELGTCMVKTH LSLSHDPKLK GVPKGWTLPI RDILTYKGAG FVVPVAGAIS LMPGTGSDPA 

       550 
YRRVDVDLQT GRVKGVF 

« Hide

References

[1]"The genome of Desulfotalea psychrophila, a sulfate-reducing bacterium from permanently cold Arctic sediments."
Rabus R., Ruepp A., Frickey T., Rattei T., Fartmann B., Stark M., Bauer M., Zibat A., Lombardot T., Becker I., Amann J., Gellner K., Teeling H., Leuschner W.D., Gloeckner F.-O., Lupas A.N., Amann R., Klenk H.-P.
Environ. Microbiol. 6:887-902(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LSv54 / DSM 12343.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR522870 Genomic DNA. Translation: CAG36956.1.
RefSeqYP_065963.1. NC_006138.1.

3D structure databases

ProteinModelPortalQ6AL19.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING177439.DP2227.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG36956; CAG36956; DP2227.
GeneID2945163.
KEGGdps:DP2227.
PATRIC21714496. VBIDesPsy67261_2439.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMAIANSVSM.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycDPSY177439:GJW5-2293-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_DESPS
AccessionPrimary (citable) accession number: Q6AL19
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: September 13, 2004
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways