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Q6AKL2 (UPPP_DESPS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:DP2384
OrganismDesulfotalea psychrophila (strain LSv54 / DSM 12343) [Complete proteome] [HAMAP]
Taxonomic identifier177439 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence caution

The sequence CAG37113.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 254254Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151144

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane41 – 6121Helical; Potential
Transmembrane71 – 9121Helical; Potential
Transmembrane97 – 11721Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane175 – 19521Helical; Potential
Transmembrane211 – 23121Helical; Potential
Transmembrane234 – 25421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q6AKL2 [UniParc].

Last modified June 12, 2007. Version 2.
Checksum: A2B19BF5C9DFDDDE

FASTA25427,978
        10         20         30         40         50         60 
MDVFQTIILG IIEGITEFLP ISSTGHLIVA SNWLSIEQNE TNKAIEVIIQ LAAILAVIAN 

        70         80         90        100        110        120 
YRDKFTLKHK VLWSKVVLAF IPIGAIGLLF HKEIKTLFTV PMVGTMFIVG GIVFLVLEHF 

       130        140        150        160        170        180 
YQERSSHVQE VEAISYRQAL WIGIAQVFAL IPGTSRAGAS IVGALLMGLS RKASAEFSFL 

       190        200        210        220        230        240 
LALPVLAAAA GFDLLTHYSD FSRGDMLTLS VGFITSFLIA YLTIRVFIGF LQRFTFVSFG 

       250 
IYRIAFGALL LWLG 

« Hide

References

[1]"The genome of Desulfotalea psychrophila, a sulfate-reducing bacterium from permanently cold Arctic sediments."
Rabus R., Ruepp A., Frickey T., Rattei T., Fartmann B., Stark M., Bauer M., Zibat A., Lombardot T., Becker I., Amann J., Gellner K., Teeling H., Leuschner W.D., Gloeckner F.-O., Lupas A.N., Amann R., Klenk H.-P.
Environ. Microbiol. 6:887-902(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LSv54 / DSM 12343.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR522870 Genomic DNA. Translation: CAG37113.1. Different initiation.
RefSeqYP_066120.1. NC_006138.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING177439.DP2384.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG37113; CAG37113; DP2384.
GeneID2944273.
KEGGdps:DP2384.
PATRIC21714824. VBIDesPsy67261_2602.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBCLSK928617.

Enzyme and pathway databases

BioCycDPSY177439:GJW5-2451-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_DESPS
AccessionPrimary (citable) accession number: Q6AKL2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: June 12, 2007
Last modified: February 19, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families