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Q6AJZ7 (SYL_DESPS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:DP2600
OrganismDesulfotalea psychrophila (strain LSv54 / DSM 12343) [Complete proteome] [HAMAP]
Taxonomic identifier177439 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea

Protein attributes

Sequence length827 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 827827Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000152010

Regions

Motif46 – 5611"HIGH" region HAMAP-Rule MF_00049
Motif585 – 5895"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site5881ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AJZ7 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 908B7BC6238F63D6

FASTA82794,774
        10         20         30         40         50         60 
MQHPTNARYD FKTIESKWQK NWAENKTYSV TEDEDKEKYY LLEMFPYPSG RIHMGHVRNY 

        70         80         90        100        110        120 
TIGDVVARYK RMRGFNVLHP MGWDAFGLPA ENAAQKNNTH PSVWTYDNID YMRQQLQQLG 

       130        140        150        160        170        180 
LSYDWDREMA TCNPKYYRQE QQLFIEMLEK GLIYEKVTTV NWCDTCQTVL ANEQVIEGAC 

       190        200        210        220        230        240 
WRCDQLVHPR KMNGWFFKIT DYAEELLADL DKLTGWPEKV RTMQRNWIGK STGLSCDFQL 

       250        260        270        280        290        300 
EDMDDKISIF TTRPDTIYGV TFMSLAPEHP LVEQLIAGTD REQEVRDFVK EVLEDKQRQD 

       310        320        330        340        350        360 
PTQEPEKKGI FTGKYCTNPF NGDRVPVYVA NFVLIEYGTG AVMAVPAHDQ RDFEFAGKYK 

       370        380        390        400        410        420 
LPIIPVVVPE GEAVNPADME EALTNHGLLI NSGDFTGMAS QEAQAKIIAY AEEKGFGSPL 

       430        440        450        460        470        480 
TTYRLRDWGI SRQRYWGAPI PIIHCDSCGI VPVPIDQLPV ELPEDKDKSS VCAPLHQRPD 

       490        500        510        520        530        540 
FINTTCPKCG QPAKRETDTM DTFVESSWYF ARYTSPRHTE APLDKAKAKY WLAVDQYIGG 

       550        560        570        580        590        600 
VEHAILHLLY SRFFTKVLRD LGYLEIDEPF IKLLTQGMVI KDGTKMSKSK GNVVDPHDLI 

       610        620        630        640        650        660 
SEFGADTTRL FSLFAAPPER DLEWSSEGVE GSSRFLNRIY RFITANFEAL TAGEAFPKKL 

       670        680        690        700        710        720 
SEEDRLLHRK NHQTIKRVTE NIEHNFHFNT AISAVMELVN QLFAQFKNEK SIAAPAVLRA 

       730        740        750        760        770        780 
SVDSVLLLLS PMVPHFCNEM WMVLGNTEPI ENQAWPEFDI EATKEDLLTI IIQVRGKVRS 

       790        800        810        820 
KIQVPVDIEE DEIVALALAD ENCQKFIDGQ PIKKTIVVKK KLVNIVI 

« Hide

References

[1]"The genome of Desulfotalea psychrophila, a sulfate-reducing bacterium from permanently cold Arctic sediments."
Rabus R., Ruepp A., Frickey T., Rattei T., Fartmann B., Stark M., Bauer M., Zibat A., Lombardot T., Becker I., Amann J., Gellner K., Teeling H., Leuschner W.D., Gloeckner F.-O., Lupas A.N., Amann R., Klenk H.-P.
Environ. Microbiol. 6:887-902(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LSv54 / DSM 12343.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR522870 Genomic DNA. Translation: CAG37329.1.
RefSeqYP_066336.1. NC_006138.1.

3D structure databases

ProteinModelPortalQ6AJZ7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING177439.DP2600.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG37329; CAG37329; DP2600.
GeneID2945276.
KEGGdps:DP2600.
PATRIC21715310. VBIDesPsy67261_2831.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAVVHCDAC.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycDPSY177439:GJW5-2681-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_DESPS
AccessionPrimary (citable) accession number: Q6AJZ7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: September 13, 2004
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries