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Q6AJZ7

- SYL_DESPS

UniProt

Q6AJZ7 - SYL_DESPS

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Desulfotalea psychrophila (strain LSv54 / DSM 12343)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei588 – 5881ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDPSY177439:GJW5-2681-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:DP2600
    OrganismiDesulfotalea psychrophila (strain LSv54 / DSM 12343)
    Taxonomic identifieri177439 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea
    ProteomesiUP000000602: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 827827Leucine--tRNA ligasePRO_0000152010Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi177439.DP2600.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AJZ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi46 – 5611"HIGH" regionAdd
    BLAST
    Motifi585 – 5895"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiVVHCDAC.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6AJZ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQHPTNARYD FKTIESKWQK NWAENKTYSV TEDEDKEKYY LLEMFPYPSG    50
    RIHMGHVRNY TIGDVVARYK RMRGFNVLHP MGWDAFGLPA ENAAQKNNTH 100
    PSVWTYDNID YMRQQLQQLG LSYDWDREMA TCNPKYYRQE QQLFIEMLEK 150
    GLIYEKVTTV NWCDTCQTVL ANEQVIEGAC WRCDQLVHPR KMNGWFFKIT 200
    DYAEELLADL DKLTGWPEKV RTMQRNWIGK STGLSCDFQL EDMDDKISIF 250
    TTRPDTIYGV TFMSLAPEHP LVEQLIAGTD REQEVRDFVK EVLEDKQRQD 300
    PTQEPEKKGI FTGKYCTNPF NGDRVPVYVA NFVLIEYGTG AVMAVPAHDQ 350
    RDFEFAGKYK LPIIPVVVPE GEAVNPADME EALTNHGLLI NSGDFTGMAS 400
    QEAQAKIIAY AEEKGFGSPL TTYRLRDWGI SRQRYWGAPI PIIHCDSCGI 450
    VPVPIDQLPV ELPEDKDKSS VCAPLHQRPD FINTTCPKCG QPAKRETDTM 500
    DTFVESSWYF ARYTSPRHTE APLDKAKAKY WLAVDQYIGG VEHAILHLLY 550
    SRFFTKVLRD LGYLEIDEPF IKLLTQGMVI KDGTKMSKSK GNVVDPHDLI 600
    SEFGADTTRL FSLFAAPPER DLEWSSEGVE GSSRFLNRIY RFITANFEAL 650
    TAGEAFPKKL SEEDRLLHRK NHQTIKRVTE NIEHNFHFNT AISAVMELVN 700
    QLFAQFKNEK SIAAPAVLRA SVDSVLLLLS PMVPHFCNEM WMVLGNTEPI 750
    ENQAWPEFDI EATKEDLLTI IIQVRGKVRS KIQVPVDIEE DEIVALALAD 800
    ENCQKFIDGQ PIKKTIVVKK KLVNIVI 827
    Length:827
    Mass (Da):94,774
    Last modified:September 13, 2004 - v1
    Checksum:i908B7BC6238F63D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR522870 Genomic DNA. Translation: CAG37329.1.
    RefSeqiYP_066336.1. NC_006138.1.

    Genome annotation databases

    EnsemblBacteriaiCAG37329; CAG37329; DP2600.
    GeneIDi2945276.
    KEGGidps:DP2600.
    PATRICi21715310. VBIDesPsy67261_2831.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR522870 Genomic DNA. Translation: CAG37329.1 .
    RefSeqi YP_066336.1. NC_006138.1.

    3D structure databases

    ProteinModelPortali Q6AJZ7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 177439.DP2600.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG37329 ; CAG37329 ; DP2600 .
    GeneIDi 2945276.
    KEGGi dps:DP2600.
    PATRICi 21715310. VBIDesPsy67261_2831.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi VVHCDAC.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci DPSY177439:GJW5-2681-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LSv54 / DSM 12343.

    Entry informationi

    Entry nameiSYL_DESPS
    AccessioniPrimary (citable) accession number: Q6AJZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3