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Q6AJZ7

- SYL_DESPS

UniProt

Q6AJZ7 - SYL_DESPS

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Protein
Leucine--tRNA ligase
Gene
leuS, DP2600
Organism
Desulfotalea psychrophila (strain LSv54 / DSM 12343)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei588 – 5881ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDPSY177439:GJW5-2681-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:DP2600
OrganismiDesulfotalea psychrophila (strain LSv54 / DSM 12343)
Taxonomic identifieri177439 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea
ProteomesiUP000000602: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 827827Leucine--tRNA ligaseUniRule annotation
PRO_0000152010Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi177439.DP2600.

Structurei

3D structure databases

ProteinModelPortaliQ6AJZ7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 5611"HIGH" regionUniRule annotation
Add
BLAST
Motifi585 – 5895"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiVVHCDAC.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AJZ7-1 [UniParc]FASTAAdd to Basket

« Hide

MQHPTNARYD FKTIESKWQK NWAENKTYSV TEDEDKEKYY LLEMFPYPSG    50
RIHMGHVRNY TIGDVVARYK RMRGFNVLHP MGWDAFGLPA ENAAQKNNTH 100
PSVWTYDNID YMRQQLQQLG LSYDWDREMA TCNPKYYRQE QQLFIEMLEK 150
GLIYEKVTTV NWCDTCQTVL ANEQVIEGAC WRCDQLVHPR KMNGWFFKIT 200
DYAEELLADL DKLTGWPEKV RTMQRNWIGK STGLSCDFQL EDMDDKISIF 250
TTRPDTIYGV TFMSLAPEHP LVEQLIAGTD REQEVRDFVK EVLEDKQRQD 300
PTQEPEKKGI FTGKYCTNPF NGDRVPVYVA NFVLIEYGTG AVMAVPAHDQ 350
RDFEFAGKYK LPIIPVVVPE GEAVNPADME EALTNHGLLI NSGDFTGMAS 400
QEAQAKIIAY AEEKGFGSPL TTYRLRDWGI SRQRYWGAPI PIIHCDSCGI 450
VPVPIDQLPV ELPEDKDKSS VCAPLHQRPD FINTTCPKCG QPAKRETDTM 500
DTFVESSWYF ARYTSPRHTE APLDKAKAKY WLAVDQYIGG VEHAILHLLY 550
SRFFTKVLRD LGYLEIDEPF IKLLTQGMVI KDGTKMSKSK GNVVDPHDLI 600
SEFGADTTRL FSLFAAPPER DLEWSSEGVE GSSRFLNRIY RFITANFEAL 650
TAGEAFPKKL SEEDRLLHRK NHQTIKRVTE NIEHNFHFNT AISAVMELVN 700
QLFAQFKNEK SIAAPAVLRA SVDSVLLLLS PMVPHFCNEM WMVLGNTEPI 750
ENQAWPEFDI EATKEDLLTI IIQVRGKVRS KIQVPVDIEE DEIVALALAD 800
ENCQKFIDGQ PIKKTIVVKK KLVNIVI 827
Length:827
Mass (Da):94,774
Last modified:September 13, 2004 - v1
Checksum:i908B7BC6238F63D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR522870 Genomic DNA. Translation: CAG37329.1.
RefSeqiYP_066336.1. NC_006138.1.

Genome annotation databases

EnsemblBacteriaiCAG37329; CAG37329; DP2600.
GeneIDi2945276.
KEGGidps:DP2600.
PATRICi21715310. VBIDesPsy67261_2831.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR522870 Genomic DNA. Translation: CAG37329.1 .
RefSeqi YP_066336.1. NC_006138.1.

3D structure databases

ProteinModelPortali Q6AJZ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 177439.DP2600.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG37329 ; CAG37329 ; DP2600 .
GeneIDi 2945276.
KEGGi dps:DP2600.
PATRICi 21715310. VBIDesPsy67261_2831.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi VVHCDAC.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci DPSY177439:GJW5-2681-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LSv54 / DSM 12343.

Entry informationi

Entry nameiSYL_DESPS
AccessioniPrimary (citable) accession number: Q6AJZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: September 13, 2004
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi