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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Desulfotalea psychrophila (strain LSv54 / DSM 12343)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei588ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDPSY177439:G1GHX-2660-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:DP2600
OrganismiDesulfotalea psychrophila (strain LSv54 / DSM 12343)
Taxonomic identifieri177439 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea
Proteomesi
  • UP000000602 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001520101 – 827Leucine--tRNA ligaseAdd BLAST827

Proteomic databases

PRIDEiQ6AJZ7

Interactioni

Protein-protein interaction databases

STRINGi177439.DP2600

Structurei

3D structure databases

ProteinModelPortaliQ6AJZ7
SMRiQ6AJZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi46 – 56"HIGH" regionAdd BLAST11
Motifi585 – 589"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q6AJZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQHPTNARYD FKTIESKWQK NWAENKTYSV TEDEDKEKYY LLEMFPYPSG
60 70 80 90 100
RIHMGHVRNY TIGDVVARYK RMRGFNVLHP MGWDAFGLPA ENAAQKNNTH
110 120 130 140 150
PSVWTYDNID YMRQQLQQLG LSYDWDREMA TCNPKYYRQE QQLFIEMLEK
160 170 180 190 200
GLIYEKVTTV NWCDTCQTVL ANEQVIEGAC WRCDQLVHPR KMNGWFFKIT
210 220 230 240 250
DYAEELLADL DKLTGWPEKV RTMQRNWIGK STGLSCDFQL EDMDDKISIF
260 270 280 290 300
TTRPDTIYGV TFMSLAPEHP LVEQLIAGTD REQEVRDFVK EVLEDKQRQD
310 320 330 340 350
PTQEPEKKGI FTGKYCTNPF NGDRVPVYVA NFVLIEYGTG AVMAVPAHDQ
360 370 380 390 400
RDFEFAGKYK LPIIPVVVPE GEAVNPADME EALTNHGLLI NSGDFTGMAS
410 420 430 440 450
QEAQAKIIAY AEEKGFGSPL TTYRLRDWGI SRQRYWGAPI PIIHCDSCGI
460 470 480 490 500
VPVPIDQLPV ELPEDKDKSS VCAPLHQRPD FINTTCPKCG QPAKRETDTM
510 520 530 540 550
DTFVESSWYF ARYTSPRHTE APLDKAKAKY WLAVDQYIGG VEHAILHLLY
560 570 580 590 600
SRFFTKVLRD LGYLEIDEPF IKLLTQGMVI KDGTKMSKSK GNVVDPHDLI
610 620 630 640 650
SEFGADTTRL FSLFAAPPER DLEWSSEGVE GSSRFLNRIY RFITANFEAL
660 670 680 690 700
TAGEAFPKKL SEEDRLLHRK NHQTIKRVTE NIEHNFHFNT AISAVMELVN
710 720 730 740 750
QLFAQFKNEK SIAAPAVLRA SVDSVLLLLS PMVPHFCNEM WMVLGNTEPI
760 770 780 790 800
ENQAWPEFDI EATKEDLLTI IIQVRGKVRS KIQVPVDIEE DEIVALALAD
810 820
ENCQKFIDGQ PIKKTIVVKK KLVNIVI
Length:827
Mass (Da):94,774
Last modified:September 13, 2004 - v1
Checksum:i908B7BC6238F63D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR522870 Genomic DNA Translation: CAG37329.1
RefSeqiWP_011189841.1, NC_006138.1

Genome annotation databases

EnsemblBacteriaiCAG37329; CAG37329; DP2600
KEGGidps:DP2600

Similar proteinsi

Entry informationi

Entry nameiSYL_DESPS
AccessioniPrimary (citable) accession number: Q6AJZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
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