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Q6AJV8

- HIS3_DESPS

UniProt

Q6AJV8 - HIS3_DESPS

Protein

Phosphoribosyl-AMP cyclohydrolase

Gene

hisI

Organism
Desulfotalea psychrophila (strain LSv54 / DSM 12343)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.UniRule annotation

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation
    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi75 – 751MagnesiumUniRule annotation
    Metal bindingi76 – 761Zinc; shared with dimeric partnerUniRule annotation
    Metal bindingi77 – 771MagnesiumUniRule annotation
    Metal bindingi79 – 791MagnesiumUniRule annotation
    Metal bindingi93 – 931Zinc; shared with dimeric partnerUniRule annotation
    Metal bindingi100 – 1001Zinc; shared with dimeric partnerUniRule annotation

    GO - Molecular functioni

    1. phosphoribosyl-AMP cyclohydrolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciDPSY177439:GJW5-2720-MONOMER.
    UniPathwayiUPA00031; UER00008.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosyl-AMP cyclohydrolaseUniRule annotation (EC:3.5.4.19UniRule annotation)
    Short name:
    PRA-CHUniRule annotation
    Gene namesi
    Name:hisIUniRule annotation
    Ordered Locus Names:DP2639
    OrganismiDesulfotalea psychrophila (strain LSv54 / DSM 12343)
    Taxonomic identifieri177439 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea
    ProteomesiUP000000602: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 127127Phosphoribosyl-AMP cyclohydrolasePRO_0000229820Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi177439.DP2639.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PRA-CH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0139.
    HOGENOMiHOG000277504.
    KOiK01496.
    OMAiHEPGIAC.
    OrthoDBiEOG6PGKB6.

    Family and domain databases

    HAMAPiMF_01021. HisI.
    InterProiIPR026660. PRA-CH.
    IPR002496. PRib_AMP_CycHydrolase_dom.
    [Graphical view]
    PfamiPF01502. PRA-CH. 1 hit.
    [Graphical view]
    ProDomiPD002610. PRA_CycHdrlase. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Q6AJV8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVELNFEKSV DGLLPAVVQD YVSGEVLMLA YINKLSWEKT LETGQAHYWS    50
    RSRNSLWLKG ESSGNVQVIH DILVDCDSDT VVFKVDQIGD AACHTGHRSC 100
    FFRRVHQGEL VVEGKPLFDP AQVYGSK 127
    Length:127
    Mass (Da):14,242
    Last modified:September 13, 2004 - v1
    Checksum:iFF7F1355EA9B52F3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR522870 Genomic DNA. Translation: CAG37368.1.
    RefSeqiYP_066375.1. NC_006138.1.

    Genome annotation databases

    EnsemblBacteriaiCAG37368; CAG37368; DP2639.
    GeneIDi2945313.
    KEGGidps:DP2639.
    PATRICi21715388. VBIDesPsy67261_2870.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR522870 Genomic DNA. Translation: CAG37368.1 .
    RefSeqi YP_066375.1. NC_006138.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 177439.DP2639.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG37368 ; CAG37368 ; DP2639 .
    GeneIDi 2945313.
    KEGGi dps:DP2639.
    PATRICi 21715388. VBIDesPsy67261_2870.

    Phylogenomic databases

    eggNOGi COG0139.
    HOGENOMi HOG000277504.
    KOi K01496.
    OMAi HEPGIAC.
    OrthoDBi EOG6PGKB6.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00008 .
    BioCyci DPSY177439:GJW5-2720-MONOMER.

    Family and domain databases

    HAMAPi MF_01021. HisI.
    InterProi IPR026660. PRA-CH.
    IPR002496. PRib_AMP_CycHydrolase_dom.
    [Graphical view ]
    Pfami PF01502. PRA-CH. 1 hit.
    [Graphical view ]
    ProDomi PD002610. PRA_CycHdrlase. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LSv54 / DSM 12343.

    Entry informationi

    Entry nameiHIS3_DESPS
    AccessioniPrimary (citable) accession number: Q6AJV8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3