Q6AJV8 (HIS3_DESPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosyl-AMP cyclohydrolase
Short name=PRA-CH
EC=3.5.4.19

Gene names

Name:	hisI
Ordered Locus Names:	DP2639

Organism

Desulfotalea psychrophila (strain LSv54 / DSM 12343) [Complete proteome] [HAMAP]

Taxonomic identifier

177439 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfobacterales › Desulfobulbaceae › Desulfotalea › Desulfotalea psychrophila

Protein attributes

Sequence length	127 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP-Rule MF_01021
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. HAMAP-Rule MF_01021
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_01021.
Sequence similarities	Belongs to the PRA-CH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	phosphoribosyl-AMP cyclohydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 127	127	Phosphoribosyl-AMP cyclohydrolase HAMAP-Rule MF_01021		PRO_0000229820

Sequences

	Sequence		Length	Mass (Da)
	Q6AJV8 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: FF7F1355EA9B52F3	FASTA	127	14,242
	10 20 30 40 50 60 MVELNFEKSV DGLLPAVVQD YVSGEVLMLA YINKLSWEKT LETGQAHYWS RSRNSLWLKG 70 80 90 100 110 120 ESSGNVQVIH DILVDCDSDT VVFKVDQIGD AACHTGHRSC FFRRVHQGEL VVEGKPLFDP AQVYGSK

References

[1]

"The genome of Desulfotalea psychrophila, a sulfate-reducing bacterium from permanently cold Arctic sediments." Rabus R., Ruepp A., Frickey T., Rattei T., Fartmann B., Stark M., Bauer M., Zibat A., Lombardot T., Becker I., Amann J., Gellner K., Teeling H., Leuschner W.D., Gloeckner F.-O., Lupas A.N., Amann R., Klenk H.-P. Environ. Microbiol. 6:887-902(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LSv54 / DSM 12343.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR522870 Genomic DNA. Translation: CAG37368.1.
RefSeq	YP_066375.1. NC_006138.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	177439.DP2639.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAG37368; CAG37368; DP2639.
GeneID	2945313.
KEGG	dps:DP2639.
PATRIC	21715388. VBIDesPsy67261_2870.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0139.
HOGENOM	HOG000277504.
KO	K01496.
OMA	GACHVGY.
ProtClustDB	CLSK2765019.
Enzyme and pathway databases
BioCyc	DPSY177439:GJW5-2720-MONOMER.
UniPathway	UPA00031; UER00008.
Family and domain databases
HAMAP	MF_01021. HisI.
InterPro	IPR026660. PRA-CH. IPR002496. PRib_AMP_CycHydrolase_dom. [Graphical view]
Pfam	PF01502. PRA-CH. 1 hit. [Graphical view]
ProDom	PD002610. PRA_CycHdrlase. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

HIS3_DESPS

Accession

Primary (citable) accession number: Q6AJV8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	September 13, 2004
Last modified:	May 29, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program