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Q6AJ53

- MURG_DESPS

UniProt

Q6AJ53 - MURG_DESPS

Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Desulfotalea psychrophila (strain LSv54 / DSM 12343)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

    Catalytic activityi

    UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity Source: UniProtKB-EC
    3. undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. lipid glycosylation Source: UniProtKB-HAMAP
    4. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    5. regulation of cell shape Source: UniProtKB-KW
    6. UDP-N-acetylgalactosamine biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciDPSY177439:GJW5-2981-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotation (EC:2.4.1.227UniRule annotation)
    Alternative name(s):
    Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
    Gene namesi
    Name:murGUniRule annotation
    Ordered Locus Names:DP2898
    OrganismiDesulfotalea psychrophila (strain LSv54 / DSM 12343)
    Taxonomic identifieri177439 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea
    ProteomesiUP000000602: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 369369UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferasePRO_0000225050Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi177439.DP2898.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AJ53.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0707.
    HOGENOMiHOG000218323.
    KOiK02563.
    OMAiITHICGP.
    OrthoDBiEOG61VZFD.

    Family and domain databases

    HAMAPiMF_00033. MurG.
    InterProiIPR006009. GlcNAc_MurG.
    IPR004276. Glyco_trans_28.
    IPR007235. Glyco_trans_28_C.
    [Graphical view]
    PfamiPF04101. Glyco_tran_28_C. 1 hit.
    PF03033. Glyco_transf_28. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01133. murG. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6AJ53-1 [UniParc]FASTAAdd to Basket

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    MKETRRKRIL LTGGGTGGHL FPAIAAAQQF CREYPGAEVL FVGTKRKMDA    50
    ETLERYGFKG VAINSYGLKG KNMRELVKAL LVLPISCLQA LFILARFRPD 100
    LVLGVGGYVT GPVVAMAKLC RRPTLIHEQN SVPGLANRKL AKLVDRVCVS 150
    LPASASCFPA DKVVFTGNPV RENLVALAAK AREVKEGVTL LVLGGSQGAR 200
    SLNRLIVEAF VGVGSESLAG INLIHQTGTK DLAWVKQAYG DAGRDVWVEP 250
    FFKDMDAVYS QADILVSRAG ATTLAELATL GKPVILVPYP FAADNHQQKN 300
    AEYYVQGGGA LLFKESELTA PQLVEAVISI ATNREQRERM EFNQRRLAPT 350
    DAAGKIVAVC RQLINRDEL 369
    Length:369
    Mass (Da):40,003
    Last modified:September 13, 2004 - v1
    Checksum:i8E3DD41DCC10F5AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR522870 Genomic DNA. Translation: CAG37627.1.
    RefSeqiWP_011190139.1. NC_006138.1.
    YP_066634.1. NC_006138.1.

    Genome annotation databases

    EnsemblBacteriaiCAG37627; CAG37627; DP2898.
    GeneIDi2945804.
    KEGGidps:DP2898.
    PATRICi21715944. VBIDesPsy67261_3146.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR522870 Genomic DNA. Translation: CAG37627.1 .
    RefSeqi WP_011190139.1. NC_006138.1.
    YP_066634.1. NC_006138.1.

    3D structure databases

    ProteinModelPortali Q6AJ53.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 177439.DP2898.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG37627 ; CAG37627 ; DP2898 .
    GeneIDi 2945804.
    KEGGi dps:DP2898.
    PATRICi 21715944. VBIDesPsy67261_3146.

    Phylogenomic databases

    eggNOGi COG0707.
    HOGENOMi HOG000218323.
    KOi K02563.
    OMAi ITHICGP.
    OrthoDBi EOG61VZFD.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci DPSY177439:GJW5-2981-MONOMER.

    Family and domain databases

    HAMAPi MF_00033. MurG.
    InterProi IPR006009. GlcNAc_MurG.
    IPR004276. Glyco_trans_28.
    IPR007235. Glyco_trans_28_C.
    [Graphical view ]
    Pfami PF04101. Glyco_tran_28_C. 1 hit.
    PF03033. Glyco_transf_28. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01133. murG. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LSv54 / DSM 12343.

    Entry informationi

    Entry nameiMURG_DESPS
    AccessioniPrimary (citable) accession number: Q6AJ53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3