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Q6AJ53

- MURG_DESPS

UniProt

Q6AJ53 - MURG_DESPS

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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene
murG, DP2898
Organism
Desulfotalea psychrophila (strain LSv54 / DSM 12343)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity.UniRule annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity Source: UniProtKB-EC
  3. undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. lipid glycosylation Source: UniProtKB-HAMAP
  4. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  5. regulation of cell shape Source: UniProtKB-KW
  6. UDP-N-acetylgalactosamine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciDPSY177439:GJW5-2981-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC:2.4.1.227)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Gene namesi
Name:murG
Ordered Locus Names:DP2898
OrganismiDesulfotalea psychrophila (strain LSv54 / DSM 12343)
Taxonomic identifieri177439 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea
ProteomesiUP000000602: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotationPRO_0000225050Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi177439.DP2898.

Structurei

3D structure databases

ProteinModelPortaliQ6AJ53.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0707.
HOGENOMiHOG000218323.
KOiK02563.
OMAiITHICGP.
OrthoDBiEOG61VZFD.

Family and domain databases

HAMAPiMF_00033. MurG.
InterProiIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view]
PfamiPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01133. murG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AJ53-1 [UniParc]FASTAAdd to Basket

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MKETRRKRIL LTGGGTGGHL FPAIAAAQQF CREYPGAEVL FVGTKRKMDA    50
ETLERYGFKG VAINSYGLKG KNMRELVKAL LVLPISCLQA LFILARFRPD 100
LVLGVGGYVT GPVVAMAKLC RRPTLIHEQN SVPGLANRKL AKLVDRVCVS 150
LPASASCFPA DKVVFTGNPV RENLVALAAK AREVKEGVTL LVLGGSQGAR 200
SLNRLIVEAF VGVGSESLAG INLIHQTGTK DLAWVKQAYG DAGRDVWVEP 250
FFKDMDAVYS QADILVSRAG ATTLAELATL GKPVILVPYP FAADNHQQKN 300
AEYYVQGGGA LLFKESELTA PQLVEAVISI ATNREQRERM EFNQRRLAPT 350
DAAGKIVAVC RQLINRDEL 369
Length:369
Mass (Da):40,003
Last modified:September 13, 2004 - v1
Checksum:i8E3DD41DCC10F5AB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR522870 Genomic DNA. Translation: CAG37627.1.
RefSeqiWP_011190139.1. NC_006138.1.
YP_066634.1. NC_006138.1.

Genome annotation databases

EnsemblBacteriaiCAG37627; CAG37627; DP2898.
GeneIDi2945804.
KEGGidps:DP2898.
PATRICi21715944. VBIDesPsy67261_3146.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR522870 Genomic DNA. Translation: CAG37627.1 .
RefSeqi WP_011190139.1. NC_006138.1.
YP_066634.1. NC_006138.1.

3D structure databases

ProteinModelPortali Q6AJ53.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 177439.DP2898.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG37627 ; CAG37627 ; DP2898 .
GeneIDi 2945804.
KEGGi dps:DP2898.
PATRICi 21715944. VBIDesPsy67261_3146.

Phylogenomic databases

eggNOGi COG0707.
HOGENOMi HOG000218323.
KOi K02563.
OMAi ITHICGP.
OrthoDBi EOG61VZFD.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci DPSY177439:GJW5-2981-MONOMER.

Family and domain databases

HAMAPi MF_00033. MurG.
InterProi IPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view ]
Pfami PF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01133. murG. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LSv54 / DSM 12343.

Entry informationi

Entry nameiMURG_DESPS
AccessioniPrimary (citable) accession number: Q6AJ53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2004
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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