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Q6AJ53 (MURG_DESPS) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

EC=2.4.1.227
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Gene names
Name:murG
Ordered Locus Names:DP2898
OrganismDesulfotalea psychrophila (strain LSv54 / DSM 12343) [Complete proteome] [HAMAP]
Taxonomic identifier177439 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity. HAMAP-Rule MF_00033

Catalytic activity

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP-Rule MF_00033

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00033

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity HAMAP-Rule MF_00033.

Sequence similarities

Belongs to the glycosyltransferase 28 family. MurG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 369369UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase HAMAP-Rule MF_00033
PRO_0000225050

Sequences

Sequence LengthMass (Da)Tools
Q6AJ53 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 8E3DD41DCC10F5AB

FASTA36940,003
        10         20         30         40         50         60 
MKETRRKRIL LTGGGTGGHL FPAIAAAQQF CREYPGAEVL FVGTKRKMDA ETLERYGFKG 

        70         80         90        100        110        120 
VAINSYGLKG KNMRELVKAL LVLPISCLQA LFILARFRPD LVLGVGGYVT GPVVAMAKLC 

       130        140        150        160        170        180 
RRPTLIHEQN SVPGLANRKL AKLVDRVCVS LPASASCFPA DKVVFTGNPV RENLVALAAK 

       190        200        210        220        230        240 
AREVKEGVTL LVLGGSQGAR SLNRLIVEAF VGVGSESLAG INLIHQTGTK DLAWVKQAYG 

       250        260        270        280        290        300 
DAGRDVWVEP FFKDMDAVYS QADILVSRAG ATTLAELATL GKPVILVPYP FAADNHQQKN 

       310        320        330        340        350        360 
AEYYVQGGGA LLFKESELTA PQLVEAVISI ATNREQRERM EFNQRRLAPT DAAGKIVAVC 


RQLINRDEL 

« Hide

References

[1]"The genome of Desulfotalea psychrophila, a sulfate-reducing bacterium from permanently cold Arctic sediments."
Rabus R., Ruepp A., Frickey T., Rattei T., Fartmann B., Stark M., Bauer M., Zibat A., Lombardot T., Becker I., Amann J., Gellner K., Teeling H., Leuschner W.D., Gloeckner F.-O., Lupas A.N., Amann R., Klenk H.-P.
Environ. Microbiol. 6:887-902(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LSv54 / DSM 12343.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR522870 Genomic DNA. Translation: CAG37627.1.
RefSeqYP_066634.1. NC_006138.1.

3D structure databases

ProteinModelPortalQ6AJ53.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING177439.DP2898.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG37627; CAG37627; DP2898.
GeneID2945804.
KEGGdps:DP2898.
PATRIC21715944. VBIDesPsy67261_3146.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0707.
HOGENOMHOG000218323.
KOK02563.
OMAITHICGP.
OrthoDBEOG61VZFD.

Enzyme and pathway databases

BioCycDPSY177439:GJW5-2981-MONOMER.
UniPathwayUPA00219.

Family and domain databases

HAMAPMF_00033. MurG.
InterProIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view]
PfamPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsTIGR01133. murG. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURG_DESPS
AccessionPrimary (citable) accession number: Q6AJ53
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2004
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways