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Q6AJ53

- MURG_DESPS

UniProt

Q6AJ53 - MURG_DESPS

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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Desulfotalea psychrophila (strain LSv54 / DSM 12343)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity Source: UniProtKB-EC
  3. undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. cell wall organization Source: UniProtKB-KW
  4. lipid glycosylation Source: UniProtKB-HAMAP
  5. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  6. regulation of cell shape Source: UniProtKB-KW
  7. UDP-N-acetylgalactosamine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciDPSY177439:GJW5-2981-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotation (EC:2.4.1.227UniRule annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
Gene namesi
Name:murGUniRule annotation
Ordered Locus Names:DP2898
OrganismiDesulfotalea psychrophila (strain LSv54 / DSM 12343)
Taxonomic identifieri177439 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobulbaceaeDesulfotalea
ProteomesiUP000000602: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferasePRO_0000225050Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi177439.DP2898.

Structurei

3D structure databases

ProteinModelPortaliQ6AJ53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0707.
HOGENOMiHOG000218323.
KOiK02563.
OMAiITHICGP.
OrthoDBiEOG61VZFD.

Family and domain databases

HAMAPiMF_00033. MurG.
InterProiIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view]
PfamiPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01133. murG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6AJ53-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKETRRKRIL LTGGGTGGHL FPAIAAAQQF CREYPGAEVL FVGTKRKMDA
60 70 80 90 100
ETLERYGFKG VAINSYGLKG KNMRELVKAL LVLPISCLQA LFILARFRPD
110 120 130 140 150
LVLGVGGYVT GPVVAMAKLC RRPTLIHEQN SVPGLANRKL AKLVDRVCVS
160 170 180 190 200
LPASASCFPA DKVVFTGNPV RENLVALAAK AREVKEGVTL LVLGGSQGAR
210 220 230 240 250
SLNRLIVEAF VGVGSESLAG INLIHQTGTK DLAWVKQAYG DAGRDVWVEP
260 270 280 290 300
FFKDMDAVYS QADILVSRAG ATTLAELATL GKPVILVPYP FAADNHQQKN
310 320 330 340 350
AEYYVQGGGA LLFKESELTA PQLVEAVISI ATNREQRERM EFNQRRLAPT
360
DAAGKIVAVC RQLINRDEL
Length:369
Mass (Da):40,003
Last modified:September 13, 2004 - v1
Checksum:i8E3DD41DCC10F5AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR522870 Genomic DNA. Translation: CAG37627.1.
RefSeqiYP_066634.1. NC_006138.1.

Genome annotation databases

EnsemblBacteriaiCAG37627; CAG37627; DP2898.
GeneIDi2945804.
KEGGidps:DP2898.
PATRICi21715944. VBIDesPsy67261_3146.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR522870 Genomic DNA. Translation: CAG37627.1 .
RefSeqi YP_066634.1. NC_006138.1.

3D structure databases

ProteinModelPortali Q6AJ53.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 177439.DP2898.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG37627 ; CAG37627 ; DP2898 .
GeneIDi 2945804.
KEGGi dps:DP2898.
PATRICi 21715944. VBIDesPsy67261_3146.

Phylogenomic databases

eggNOGi COG0707.
HOGENOMi HOG000218323.
KOi K02563.
OMAi ITHICGP.
OrthoDBi EOG61VZFD.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci DPSY177439:GJW5-2981-MONOMER.

Family and domain databases

HAMAPi MF_00033. MurG.
InterProi IPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view ]
Pfami PF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01133. murG. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LSv54 / DSM 12343.

Entry informationi

Entry nameiMURG_DESPS
AccessioniPrimary (citable) accession number: Q6AJ53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2004
Last modified: November 26, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3