Reviewed, UniProtKB/Swiss-Prot Q6AI12 (ANR40_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat domain-containing protein 40

Gene names

Name:

ANKRD40

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	368 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Contains 2 ANK repeats.

Ontologies

Keywords
Domain	ANK repeat Repeat
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 368	368	Ankyrin repeat domain-containing protein 40		PRO_0000244368
Regions
	Repeat	9 – 38	30	ANK 1
	Repeat	43 – 72	30	ANK 2
	Compositional bias	99 – 106	8	Poly-Asp
	Compositional bias	148 – 247	100	Pro-rich
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine
Experimental info
	Sequence conflict	352	1	T → A in CAH10502. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q6AI12-1 [UniParc]. Last modified June 27, 2006. Version 2. Checksum: 17999B7FDD3C6A52	FASTA	368	41,088
	10 20 30 40 50 60 MNALLEQKEQ QERLREAAAL GDIREVQKLV ESGVDVNSQN EVNGWTCLHW ACKRNHGQVV 70 80 90 100 110 120 SYLLKSGADK EILTTKGEMP VQLTSRREIR KIMGVEEEDD DDDDDDNLPQ LKKESELPFV 130 140 150 160 170 180 PNYLANPAFP FIYTPTAEDS AQMQNGGPST PPASPPADGS PPLLPPGEPP LLGTFPRDHT 190 200 210 220 230 240 SLALVQNGDV SAPSAILRTP ESTKPGPVCQ PPVSQSRSLF SSVPSKPPMS LEPQNGTYAG 250 260 270 280 290 300 PAPAFQPFFF TGAFPFNMQE LVLKVRIQNP SLRENDFIEI ELDRQELTYQ ELLRVCCCEL 310 320 330 340 350 360 GVNPDQVEKI RKLPNTLLRK DKDVARLQDF QELELVLMIS ENNFLFRNAA STLTERPCYN RRASKLTY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skeletal muscle.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
[3]	Bienvenut W.V., Lempens A., Norman J.C. Submitted (OCT-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 1-13 AND 178-198, ACETYLATION AT MET-1, MASS SPECTROMETRY. Tissue: Ovarian carcinoma.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR627413 mRNA. Translation: CAH10502.1. BC012978 mRNA. Translation: AAH12978.1.
IPI	IPI00061168.
RefSeq	NP_443087.1.
UniGene	Hs.463426
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q6AI12.
Proteomic databases
PeptideAtlas	Q6AI12.
PRIDE	Q6AI12.
Genome annotation databases
Ensembl	ENST00000285243; ENSP00000285243; ENSG00000154945; Homo sapiens. [Genome view]
GeneID	91369.
KEGG	hsa:91369.
UCSC	uc002iso.1. human.
Organism-specific databases
CTD	91369.
GeneCards	GC17M046128.
HGNC	HGNC:28233. ANKRD40.
HPA	HPA021668. HPA021759.
PharmGKB	PA142672607.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG715451.
HOVERGEN	Q6AI12.
InParanoid	Q6AI12.
OMA	QNEVNGW.
OrthoDB	EOG9BK7PR.
Gene expression databases
ArrayExpress	Q6AI12.
Bgee	Q6AI12.
CleanEx	HS_ANKRD40.
Genevestigator	Q6AI12.
GermOnline	ENSG00000154945. Homo sapiens.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 2 hits. [Graphical view]
SMART	SM00248. ANK. 2 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	77207.

Entry information

Entry name

ANR40_HUMAN

Accession

Primary (citable) accession number: Q6AI12
Secondary accession number(s): Q96E32

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	December 15, 2009
This is version 47 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.