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Protein

Ankyrin repeat domain-containing protein 40

Gene

ANKRD40

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 40
Gene namesi
Name:ANKRD40
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28233. ANKRD40.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672607.

Polymorphism and mutation databases

BioMutaiANKRD40.
DMDMi109940224.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Ankyrin repeat domain-containing protein 40PRO_0000244368Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ6AI12.
MaxQBiQ6AI12.
PaxDbiQ6AI12.
PeptideAtlasiQ6AI12.
PRIDEiQ6AI12.

PTM databases

iPTMnetiQ6AI12.
PhosphoSiteiQ6AI12.

Expressioni

Gene expression databases

BgeeiENSG00000154945.
CleanExiHS_ANKRD40.
ExpressionAtlasiQ6AI12. baseline and differential.
GenevisibleiQ6AI12. HS.

Organism-specific databases

HPAiHPA021668.
HPA021759.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AHCYP235263EBI-2838246,EBI-1053240
PIN1Q135263EBI-2838246,EBI-714158
RAD23AP547253EBI-2838246,EBI-746453
SDCBPO005603EBI-2838246,EBI-727004

Protein-protein interaction databases

BioGridi124821. 31 interactions.
IntActiQ6AI12. 7 interactions.
STRINGi9606.ENSP00000285243.

Structurei

3D structure databases

ProteinModelPortaliQ6AI12.
SMRiQ6AI12. Positions 12-104.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati9 – 3830ANK 1Add
BLAST
Repeati43 – 7230ANK 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi99 – 1068Poly-Asp
Compositional biasi148 – 247100Pro-richAdd
BLAST

Sequence similaritiesi

Contains 2 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IN88. Eukaryota.
ENOG410XSX1. LUCA.
GeneTreeiENSGT00390000007792.
HOGENOMiHOG000294200.
HOVERGENiHBG058022.
InParanoidiQ6AI12.
OMAiPFFFTGA.
OrthoDBiEOG091G0X80.
PhylomeDBiQ6AI12.
TreeFamiTF331472.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AI12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNALLEQKEQ QERLREAAAL GDIREVQKLV ESGVDVNSQN EVNGWTCLHW
60 70 80 90 100
ACKRNHGQVV SYLLKSGADK EILTTKGEMP VQLTSRREIR KIMGVEEEDD
110 120 130 140 150
DDDDDDNLPQ LKKESELPFV PNYLANPAFP FIYTPTAEDS AQMQNGGPST
160 170 180 190 200
PPASPPADGS PPLLPPGEPP LLGTFPRDHT SLALVQNGDV SAPSAILRTP
210 220 230 240 250
ESTKPGPVCQ PPVSQSRSLF SSVPSKPPMS LEPQNGTYAG PAPAFQPFFF
260 270 280 290 300
TGAFPFNMQE LVLKVRIQNP SLRENDFIEI ELDRQELTYQ ELLRVCCCEL
310 320 330 340 350
GVNPDQVEKI RKLPNTLLRK DKDVARLQDF QELELVLMIS ENNFLFRNAA
360
STLTERPCYN RRASKLTY
Length:368
Mass (Da):41,088
Last modified:June 27, 2006 - v2
Checksum:i17999B7FDD3C6A52
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti352 – 3521T → A in CAH10502 (PubMed:17974005).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR627413 mRNA. Translation: CAH10502.1.
BC012978 mRNA. Translation: AAH12978.1.
CCDSiCCDS11572.1.
RefSeqiNP_443087.1. NM_052855.3.
UniGeneiHs.463426.

Genome annotation databases

EnsembliENST00000285243; ENSP00000285243; ENSG00000154945.
GeneIDi91369.
KEGGihsa:91369.
UCSCiuc002iso.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR627413 mRNA. Translation: CAH10502.1.
BC012978 mRNA. Translation: AAH12978.1.
CCDSiCCDS11572.1.
RefSeqiNP_443087.1. NM_052855.3.
UniGeneiHs.463426.

3D structure databases

ProteinModelPortaliQ6AI12.
SMRiQ6AI12. Positions 12-104.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124821. 31 interactions.
IntActiQ6AI12. 7 interactions.
STRINGi9606.ENSP00000285243.

PTM databases

iPTMnetiQ6AI12.
PhosphoSiteiQ6AI12.

Polymorphism and mutation databases

BioMutaiANKRD40.
DMDMi109940224.

Proteomic databases

EPDiQ6AI12.
MaxQBiQ6AI12.
PaxDbiQ6AI12.
PeptideAtlasiQ6AI12.
PRIDEiQ6AI12.

Protocols and materials databases

DNASUi91369.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285243; ENSP00000285243; ENSG00000154945.
GeneIDi91369.
KEGGihsa:91369.
UCSCiuc002iso.4. human.

Organism-specific databases

CTDi91369.
GeneCardsiANKRD40.
HGNCiHGNC:28233. ANKRD40.
HPAiHPA021668.
HPA021759.
neXtProtiNX_Q6AI12.
PharmGKBiPA142672607.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IN88. Eukaryota.
ENOG410XSX1. LUCA.
GeneTreeiENSGT00390000007792.
HOGENOMiHOG000294200.
HOVERGENiHBG058022.
InParanoidiQ6AI12.
OMAiPFFFTGA.
OrthoDBiEOG091G0X80.
PhylomeDBiQ6AI12.
TreeFamiTF331472.

Miscellaneous databases

ChiTaRSiANKRD40. human.
GenomeRNAii91369.
PROiQ6AI12.

Gene expression databases

BgeeiENSG00000154945.
CleanExiHS_ANKRD40.
ExpressionAtlasiQ6AI12. baseline and differential.
GenevisibleiQ6AI12. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANR40_HUMAN
AccessioniPrimary (citable) accession number: Q6AI12
Secondary accession number(s): Q96E32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: September 7, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.