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Protein

Zinc finger protein 518A

Gene

ZNF518A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri150 – 17223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri207 – 22923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri234 – 25623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri262 – 28524C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1449 – 147123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 518A
Gene namesi
Name:ZNF518A
Synonyms:KIAA0335, ZNF518
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:29009. ZNF518A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410182.

Polymorphism and mutation databases

BioMutaiZNF518A.
DMDMi109896331.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14831483Zinc finger protein 518APRO_0000240849Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki24 – 24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki357 – 357Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki713 – 713Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki994 – 994Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1446 – 1446Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ6AHZ1.
MaxQBiQ6AHZ1.
PRIDEiQ6AHZ1.

PTM databases

iPTMnetiQ6AHZ1.
PhosphoSiteiQ6AHZ1.

Expressioni

Gene expression databases

CleanExiHS_ZNF518A.
ExpressionAtlasiQ6AHZ1. baseline and differential.
GenevisibleiQ6AHZ1. HS.

Interactioni

Protein-protein interaction databases

BioGridi115184. 15 interactions.
IntActiQ6AHZ1. 15 interactions.
MINTiMINT-1200026.

Structurei

3D structure databases

ProteinModelPortaliQ6AHZ1.
SMRiQ6AHZ1. Positions 207-287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri150 – 17223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri207 – 22923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri234 – 25623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri262 – 28524C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1449 – 147123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00530000064040.
HOGENOMiHOG000155775.
HOVERGENiHBG098619.
InParanoidiQ6AHZ1.
OMAiVDGKQHI.
OrthoDBiEOG7FJGZX.
PhylomeDBiQ6AHZ1.

Family and domain databases

InterProiIPR027775. C2H2_Znf_fam.
IPR027760. ZNF518A.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 4 hits.
PTHR10032:SF198. PTHR10032:SF198. 4 hits.
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6AHZ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSEQKQLFC DEKQTTLKKD YDVKNEIVDR SAPKPKISGS IHYALKNVKI
60 70 80 90 100
DLPKINIPNE VLLKHEVDKY RKLFQSKQQT ARKSISIKTV SCVEECTLLH
110 120 130 140 150
KSERAEEEGV KMSAKILNFS CLKCRDNTRY SPNDLQKHFQ MWHHGELPSY
160 170 180 190 200
PCEMCNFSAN DFQVFKQHRR THRSTLVKCD ICNNESVYTL LNLTKHFTST
210 220 230 240 250
HCVNGNFQCE KCKFSTQDVG TFVQHIHRHN EIHYKCGKCH HVCFTKGELQ
260 270 280 290 300
KHLHIHSGTF PFTCQYCSYG ATRREHLVRH VITLHKEHLY AKEKLEKDKY
310 320 330 340 350
EKRMAKTSAG LKLILKRYKI GASRKTFWKR KKINSGSDRS IEKNTQVLKK
360 370 380 390 400
MNKTQTKSED QSHVVQEHLS EEKDERLHCE NNDKAPESES EKPTPLSTGQ
410 420 430 440 450
GNRAEEGPNA SSGFMKTAVL GPTLKNVMMK NNKLAVSPNY NATFMGFKMM
460 470 480 490 500
DGKQHIVLKL VPIKQNVCSP GSQSGAAKDG TANLQPQTLD TNGFLTGVTT
510 520 530 540 550
ELNDTVYMKA ATPFSCSSSI LSGKASSEKE MTLISQRNNM LQTMDYEKSV
560 570 580 590 600
SSLSATSELV TASVNLTTKF ETRDNVDFWG NHLTQSHPEV LGTTIKSPDK
610 620 630 640 650
VNCVAKPNAY NSGDMHNYCI NYGNCELPVE SSNQGSLPFH NYSKVNNSNK
660 670 680 690 700
RRRFSGTAVY ENPQRESSSS KTVVQQPISE SFLSLVRQES SKPDSLLASI
710 720 730 740 750
SLLNDKDGTL KAKSEIEEQY VLEKGQNIDG QNLYSNENQN LECATEKSKW
760 770 780 790 800
EDFSNVDSPM MPRITSVFSL QSQQASEFLP PEVNQLLQDV LKIKPDVKQD
810 820 830 840 850
SSNTPNKGLP LHCDQSFQKH EREGKIVESS KDFKVQGIFP VPPGSVGINV
860 870 880 890 900
PTNDLNLKFG KEKQVSSIPQ DVRDSEKMPR ISGFGTLLKT QSDAIITQQL
910 920 930 940 950
VKDKLRATTQ NLGSFYMQSP LLNSEQKKTI IVQTSKGFLI PLNITNKPGL
960 970 980 990 1000
PVIPGNALPL VNSQGIPASL FVNKKPGMVL TLNNGKLEGV SAVKTEGAPA
1010 1020 1030 1040 1050
RGTVTKEPCK TPILKVEPNN NCLTPGLCSS IGSCLSMKSS SENTLPLKGP
1060 1070 1080 1090 1100
YILKPTSSVK AVLIPNMLSE QQSTKLNISD SVKQQNEIFP KPPLYTFLPD
1110 1120 1130 1140 1150
GKQAVFLKCV MPNKTELLKP KLVQNSTYQN IQPKKPEGTP QRILLKIFNP
1160 1170 1180 1190 1200
VLNVTAANNL SVSNSASSLQ KDNVPSNQII GGEQKEPESR DALPFLLDDL
1210 1220 1230 1240 1250
MPANEIVITS TATCPESSEE PICVSDCSES RVLRCKTNCR IERNFNRKKT
1260 1270 1280 1290 1300
SKKIFSKTKT HGSKDSETAF VSRNRNCKRK CRDSYQEPPR RKATLHRKCK
1310 1320 1330 1340 1350
EKAKPEDVRE TFGFSRPRLS KDSIRTLRLF PFSSKQLVKC PRRNQPVVVL
1360 1370 1380 1390 1400
NHPDADAPEV VSVMKTIAKF NGHVLKVSLS KRTINALLKP VCYNPPKTTY
1410 1420 1430 1440 1450
DDFSKRHKTF KPVSSVKERF VLKLTLKKTS KNNYQIVKTT SENILKAKFN
1460 1470 1480
CWFCGRVFDN QDTWAGHGQR HLMEATRDWN MLE
Length:1,483
Mass (Da):166,782
Last modified:June 27, 2006 - v2
Checksum:i8202CFBDD12F9CB0
GO
Isoform 2 (identifier: Q6AHZ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-530: Missing.

Note: No experimental confirmation available.
Show »
Length:953
Mass (Da):106,407
Checksum:i20E3A04EA85253B0
GO

Sequence cautioni

The sequence AAH30967.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA20793.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti231 – 2311E → G in AAH30967 (PubMed:15489334).Curated
Sequence conflicti978 – 9781M → V in CAH10523 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti946 – 9461N → H.
Corresponds to variant rs3814228 [ dbSNP | Ensembl ].
VAR_046310
Natural varianti1328 – 13281R → Q.
Corresponds to variant rs3814226 [ dbSNP | Ensembl ].
VAR_046311

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 530530Missing in isoform 2. 1 PublicationVSP_019436Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002333 mRNA. Translation: BAA20793.2. Different initiation.
CR627437 mRNA. Translation: CAH10523.1.
BC030967 mRNA. Translation: AAH30967.1. Sequence problems.
BC109045 mRNA. Translation: AAI09046.1.
BC109046 mRNA. Translation: AAI09047.1.
CCDSiCCDS73170.1. [Q6AHZ1-1]
RefSeqiNP_001265453.1. NM_001278524.1. [Q6AHZ1-1]
NP_001265454.1. NM_001278525.1. [Q6AHZ1-1]
NP_001265455.1. NM_001278526.1. [Q6AHZ1-2]
NP_055618.2. NM_014803.3. [Q6AHZ1-1]
XP_011538707.1. XM_011540405.1. [Q6AHZ1-1]
XP_011538708.1. XM_011540406.1. [Q6AHZ1-1]
XP_011538709.1. XM_011540407.1. [Q6AHZ1-1]
XP_011538710.1. XM_011540408.1. [Q6AHZ1-1]
XP_011538711.1. XM_011540409.1. [Q6AHZ1-1]
XP_011538712.1. XM_011540410.1. [Q6AHZ1-1]
XP_011538713.1. XM_011540411.1. [Q6AHZ1-1]
XP_011538714.1. XM_011540412.1. [Q6AHZ1-1]
XP_011538715.1. XM_011540413.1. [Q6AHZ1-1]
XP_011538716.1. XM_011540414.1. [Q6AHZ1-1]
XP_011538717.1. XM_011540415.1. [Q6AHZ1-1]
XP_011538718.1. XM_011540416.1. [Q6AHZ1-1]
XP_011538719.1. XM_011540417.1. [Q6AHZ1-1]
XP_011538720.1. XM_011540418.1. [Q6AHZ1-1]
XP_011538721.1. XM_011540419.1. [Q6AHZ1-1]
XP_011538722.1. XM_011540420.1. [Q6AHZ1-1]
XP_011538723.1. XM_011540421.1. [Q6AHZ1-1]
UniGeneiHs.600823.
Hs.651650.

Genome annotation databases

EnsembliENST00000316045; ENSP00000479684; ENSG00000177853. [Q6AHZ1-1]
ENST00000614149; ENSP00000481657; ENSG00000177853. [Q6AHZ1-1]
ENST00000624776; ENSP00000485614; ENSG00000177853. [Q6AHZ1-1]
GeneIDi9849.
KEGGihsa:9849.
UCSCiuc031wpm.2. human. [Q6AHZ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002333 mRNA. Translation: BAA20793.2. Different initiation.
CR627437 mRNA. Translation: CAH10523.1.
BC030967 mRNA. Translation: AAH30967.1. Sequence problems.
BC109045 mRNA. Translation: AAI09046.1.
BC109046 mRNA. Translation: AAI09047.1.
CCDSiCCDS73170.1. [Q6AHZ1-1]
RefSeqiNP_001265453.1. NM_001278524.1. [Q6AHZ1-1]
NP_001265454.1. NM_001278525.1. [Q6AHZ1-1]
NP_001265455.1. NM_001278526.1. [Q6AHZ1-2]
NP_055618.2. NM_014803.3. [Q6AHZ1-1]
XP_011538707.1. XM_011540405.1. [Q6AHZ1-1]
XP_011538708.1. XM_011540406.1. [Q6AHZ1-1]
XP_011538709.1. XM_011540407.1. [Q6AHZ1-1]
XP_011538710.1. XM_011540408.1. [Q6AHZ1-1]
XP_011538711.1. XM_011540409.1. [Q6AHZ1-1]
XP_011538712.1. XM_011540410.1. [Q6AHZ1-1]
XP_011538713.1. XM_011540411.1. [Q6AHZ1-1]
XP_011538714.1. XM_011540412.1. [Q6AHZ1-1]
XP_011538715.1. XM_011540413.1. [Q6AHZ1-1]
XP_011538716.1. XM_011540414.1. [Q6AHZ1-1]
XP_011538717.1. XM_011540415.1. [Q6AHZ1-1]
XP_011538718.1. XM_011540416.1. [Q6AHZ1-1]
XP_011538719.1. XM_011540417.1. [Q6AHZ1-1]
XP_011538720.1. XM_011540418.1. [Q6AHZ1-1]
XP_011538721.1. XM_011540419.1. [Q6AHZ1-1]
XP_011538722.1. XM_011540420.1. [Q6AHZ1-1]
XP_011538723.1. XM_011540421.1. [Q6AHZ1-1]
UniGeneiHs.600823.
Hs.651650.

3D structure databases

ProteinModelPortaliQ6AHZ1.
SMRiQ6AHZ1. Positions 207-287.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115184. 15 interactions.
IntActiQ6AHZ1. 15 interactions.
MINTiMINT-1200026.

PTM databases

iPTMnetiQ6AHZ1.
PhosphoSiteiQ6AHZ1.

Polymorphism and mutation databases

BioMutaiZNF518A.
DMDMi109896331.

Proteomic databases

EPDiQ6AHZ1.
MaxQBiQ6AHZ1.
PRIDEiQ6AHZ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316045; ENSP00000479684; ENSG00000177853. [Q6AHZ1-1]
ENST00000614149; ENSP00000481657; ENSG00000177853. [Q6AHZ1-1]
ENST00000624776; ENSP00000485614; ENSG00000177853. [Q6AHZ1-1]
GeneIDi9849.
KEGGihsa:9849.
UCSCiuc031wpm.2. human. [Q6AHZ1-1]

Organism-specific databases

CTDi9849.
GeneCardsiZNF518A.
HGNCiHGNC:29009. ZNF518A.
neXtProtiNX_Q6AHZ1.
PharmGKBiPA162410182.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000064040.
HOGENOMiHOG000155775.
HOVERGENiHBG098619.
InParanoidiQ6AHZ1.
OMAiVDGKQHI.
OrthoDBiEOG7FJGZX.
PhylomeDBiQ6AHZ1.

Miscellaneous databases

GenomeRNAii9849.
NextBioi37122.
PROiQ6AHZ1.

Gene expression databases

CleanExiHS_ZNF518A.
ExpressionAtlasiQ6AHZ1. baseline and differential.
GenevisibleiQ6AHZ1. HS.

Family and domain databases

InterProiIPR027775. C2H2_Znf_fam.
IPR027760. ZNF518A.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 4 hits.
PTHR10032:SF198. PTHR10032:SF198. 4 hits.
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Retina.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-338 (ISOFORM 1).
    Tissue: Lung.
  5. "Uncovering global SUMOylation signaling networks in a site-specific manner."
    Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M., Vertegaal A.C.
    Nat. Struct. Mol. Biol. 21:927-936(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-713 AND LYS-994, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability."
    Xiao Z., Chang J.G., Hendriks I.A., Sigurdsson J.O., Olsen J.V., Vertegaal A.C.
    Mol. Cell. Proteomics 14:1419-1434(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-24; LYS-357; LYS-713; LYS-994 AND LYS-1446, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZ518A_HUMAN
AccessioniPrimary (citable) accession number: Q6AHZ1
Secondary accession number(s): A0PJI5, O15044, Q32MP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: April 13, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.