Q6AHN6 (DNAA_LEIXX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA

Gene names

Name:	dnaA
Ordered Locus Names:	Lxx00010

Organism

Leifsonia xyli subsp. xyli (strain CTCB07) [Complete proteome] [HAMAP]

Taxonomic identifier

281090 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Microbacteriaceae › Leifsonia

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Cytoplasm
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: InterPro regulation of DNA replication Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA replication origin binding Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 473	473	Chromosomal replication initiator protein DnaA HAMAP MF_00377		PRO_0000114198
Regions
	Nucleotide binding	174 – 181	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6AHN6 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 0CCE6EEB3D5F2CC0	FASTA	473	53,010
	10 20 30 40 50 60 MADGEESISV AWQSVLDKLE TDDRITPQLH GFLSLVEPKG IMAGTFYLEV PNEFTRGMIE 70 80 90 100 110 120 QRSRVPLLNA IGTLDNTLAV TTFAIVVNPE IQQESLSTVG EPEPTPAPYL DVATFTVAPP 130 140 150 160 170 180 AEITAPPRNG DTRLNSKYSF DNFVIGQSNR FAHAAAVAVA EAPAKAYNPL FIYGDSGLGK 190 200 210 220 230 240 THLLHAIGHY AMSLYPGIRV RYVSSEEFTN DFINSIANNR GSSFQARYRN IDILLIDDIQ 250 260 270 280 290 300 FLQRAVETQE AFFHTFNTLH DHNKQVVITS DLPPKHLTGF EDRMRSRFEW GLITDVQVPD 310 320 330 340 350 360 LETRIAILRK KAQSEKIQVP DDILEFMASK ISSNIRELEG TLIRVTAFAS LNRTPVDMPL 370 380 390 400 410 420 VQTVLKDLIT LDDDNVIAPT DIITNTAEYF KLTVDDLYGS SRSQAVATAR QIAMYLCREL 430 440 450 460 470 TNLSLPKIGQ LFGGRDHTTV MYANKKISEL MKERRSIYNQ VTELTSRIKQ NHR

References

[1]

"The genome sequence of the Gram-positive sugarcane pathogen Leifsonia xyli subsp. xyli." Monteiro-Vitorello C.B., Camargo L.E.A., Van Sluys M.A., Kitajima J.P., Truffi D., do Amaral A.M., Harakava R., de Oliveira J.C.F., Wood D., de Oliveira M.C., Miyaki C.Y., Takita M.A., da Silva A.C.R., Furlan L.R., Carraro D.M., Camarotte G., Almeida N.F. Jr., Carrer H. , Coutinho L.L., El-Dorry H.A., Ferro M.I.T., Gagliardi P.R., Giglioti E., Goldman M.H.S., Goldman G.H., Kimura E.T., Ferro E.S., Kuramae E.E., Lemos E.G.M., Lemos M.V.F., Mauro S.M.Z., Machado M.A., Marino C.L., Menck C.F., Nunes L.R., Oliveira R.C., Pereira G.G., Siqueira W., de Souza A.A., Tsai S.M., Zanca A.S., Simpson A.J.G., Brumbley S.M., Setubal J.C. Mol. Plant Microbe Interact. 17:827-836(2004) [PubMed: 15305603] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CTCB07.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016822 Genomic DNA. Translation: AAT88109.1.
RefSeq	YP_061214.1. NC_006087.1.
3D structure databases
ProteinModelPortal	Q6AHN6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2938735.
GenomeReviews	Gene locus Lxx00010 in contig AE016822_GR.
KEGG	lxx:Lxx00010.
NMPDR	fig|281090.3.peg.1136.
PATRIC	22333440. VBILeiXyl11655_0001.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG695666.
OMA	DEVAFLI.
ProtClustDB	PRK00149.
Enzyme and pathway databases
BioCyc	LXYL281090:LXX00010-MONOMER.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAA_LEIXX

Accession

Primary (citable) accession number: Q6AHN6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	September 13, 2004
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program