Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q6AHN0 (Q6AHN0_LEIXX) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897
Gene names
Name:gyrA HAMAP MF_01897 EMBL AAT88115.1
Ordered Locus Names:Lxx00070
OrganismLeifsonia xyli subsp. xyli (strain CTCB07) [Complete proteome] [HAMAP]
Taxonomic identifier281090 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Microbacteriaceae › Leifsonia

Protein attributes

Sequence length858 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897

Subunit structure

Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897

Subcellular location

Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Sequences

Sequence LengthMass (Da)Tools
Q6AHN0 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: B6E0ACB4F4220F56

FASTA85895,040
        10         20         30         40         50         60 
MTDEENAGAV FGIHGKIDQV DLQSEMQRSY LDYAMSVIIG RALPEVRDGL KPVHRRVIYA 

        70         80         90        100        110        120 
MFDGGYRPDK AFSKCARVVG DVMGQFHPHG DSAIYDALVR LVQPWSLRYP LALGQGNFGS 

       130        140        150        160        170        180 
PGNDGAAAPR YTETKMAPLA LEMVRDIDED TVDFQDNYDG RTQEPSVLPS RFPNLLVNGS 

       190        200        210        220        230        240 
VGIAVGMATN IPPHNLREVA QGALWHLAHP EASREELLEE LIKRIKGPDF PTGAQILGVK 

       250        260        270        280        290        300 
GIQDTYRTGR GSITIRAVVS IEEIQGRVCL VVTELPYQVN PDNLAIKIAE LVKDGRVGGI 

       310        320        330        340        350        360 
ADIRDETSGR TGQRLVIVLK RDAVAKVVLN NLYKHTQLQE NFGANMLAIV DNVPRTLALD 

       370        380        390        400        410        420 
GFITAWVDHQ IEVIVRRTRF RLRKAEERAH ILRGYLKALD ALDEVIALIR RSATVDEARE 

       430        440        450        460        470        480 
GLKSLLEVDD IQADAILAMQ LRRLAALERQ KIIDEHDEIE RQITEFKAIL ADSARQRSIV 

       490        500        510        520        530        540 
SEELTEIVDR FGDDRRTEIM LGFDGDMSLE DLIPEEEMVI TVTRGGYIKR TRSDNYRSQH 

       550        560        570        580        590        600 
RGGKGVKGAQ LRGEDVVDHF FVTTTHHWLL FFTKKGRVYR AKAYEVQEAG RDAKGQHVAN 

       610        620        630        640        650        660 
LLALQPDEEI AEILDIRDYE VAQYLVLATR DGLIKKTALR EYDTNRSGGI IAIKLRDEDE 

       670        680        690        700        710        720 
LVSALLVEED SDLLLVSRKG MSIRFTATDE AMRPMGRSTS GVIGMHFRGD DSLLDASVVS 

       730        740        750        760        770        780 
DEGYVFVVTE GGYAKRTAAD QYRLQNRGGL GIKVAKLSDD RGDLVGALIV EEDDEVLVVL 

       790        800        810        820        830        840 
ASGKVVRSAV AEVPAKGRDT MGVVFARFAE TDKIIALAKN TERNLDSQET DADSSAETET 

       850 
VTGEDAGDGG KEETVDEQ

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016822 Genomic DNA. Translation: AAT88115.1.
RefSeqYP_061220.1. NC_006087.1.

3D structure databases

ProteinModelPortalQ6AHN0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2938465.
GenomeReviewsGene locus Lxx00070 in contig AE016822_GR.
KEGGlxx:Lxx00070.
NMPDRfig|281090.3.peg.1142.
PATRIC22333452. VBILeiXyl11655_0007.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG635183.
OMATGRGRIY.
ProtClustDBPRK05560.

Family and domain databases

HAMAPMF_01897. GyrA.
[Tree]
InterProIPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_cen.
[Graphical view]
Gene3DG3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit.
G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KOK02469.
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. GyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ6AHN0_LEIXX
AccessionPrimary (citable) accession number: Q6AHN0
Entry history
Integrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info