Reviewed, UniProtKB/Swiss-Prot Q6AHH7 (MTLD_LEIXX)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	Lxx00800

Organism

Leifsonia xyli subsp. xyli [Complete proteome] [HAMAP]

Taxonomic identifier

59736 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Microbacteriaceae › Leifsonia

Protein attributes

Sequence length	383 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 383	383	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_0000170710
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6AHH7-1 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 58D9F67985E459DC	FASTA	383	40,242
	10 20 30 40 50 60 MKAVHFGAGN IGRGFVGLLL HEAGYEVVFA DVNAELIEAL AAADSYDVRL VGDETVTKTV 70 80 90 100 110 120 TGFRALNSAT AEDELVGEIA TADVVTTAVG PRILRFVAPV IARGLGARAS GAPRLVVMAC 130 140 150 160 170 180 ENAIGATDLL AAELMDGLQD GDTRDELAAR AVFANTAVDR IVPAQDPASG VDVTVEAFFE 190 200 210 220 230 240 WVVDRSPFAG AEPPIPGAHF VDSLGPYIER KLFTVNTGHA TTAYTGFLEG AATISEAIAK 250 260 270 280 290 300 PSVLATVEAV LEETSAALTA KHGLDPEELA EYRAKILNRF RNPHLVDEVT RVGREPLRKL 310 320 330 340 350 360 GRNDRFIGPA SDYARYVGGA PSALLAAVGA ALRFDLPGDS QSAELQQLLR KTEPGGIVTE 370 380 VMGVEPGDAL YEPLVAVVRT AQG

References

[1]

"The genome sequence of the Gram-positive sugarcane pathogen Leifsonia xyli subsp. xyli." Monteiro-Vitorello C.B., Camargo L.E.A., Van Sluys M.A., Kitajima J.P., Truffi D., do Amaral A.M., Harakava R., de Oliveira J.C.F., Wood D., de Oliveira M.C., Miyaki C.Y., Takita M.A., da Silva A.C.R., Furlan L.R., Carraro D.M., Camarotte G., Almeida N.F. Jr., Carrer H. , Coutinho L.L., El-Dorry H.A., Ferro M.I.T., Gagliardi P.R., Giglioti E., Goldman M.H.S., Goldman G.H., Kimura E.T., Ferro E.S., Kuramae E.E., Lemos E.G.M., Lemos M.V.F., Mauro S.M.Z., Machado M.A., Marino C.L., Menck C.F., Nunes L.R., Oliveira R.C., Pereira G.G., Siqueira W., de Souza A.A., Tsai S.M., Zanca A.S., Simpson A.J.G., Brumbley S.M., Setubal J.C. Mol. Plant Microbe Interact. 17:827-836(2004) [PubMed: 15305603] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CTCB07.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016822 Genomic DNA. Translation: AAT88168.1.
RefSeq	YP_061273.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2938322.
GenomeReviews	Gene locus Lxx00800 in contig AE016822_GR.
KEGG	lxx:Lxx00800.
NMPDR	fig|281090.3.peg.1195.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG568825.
OMA	VDRIVPN.
Enzyme and pathway databases
BioCyc	LXYL281090:LXX00800-MONOMER.
BRENDA	1.1.1.17. 297084.
Family and domain databases
HAMAP	MF_00196. Mannitol_dehydrog. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_LEIXX

Accession

Primary (citable) accession number: Q6AHH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 2, 2005
Last sequence update:	September 13, 2004
Last modified:	January 19, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)