Q6AHF2 (HEMH_LEIXX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferrochelatase
EC=4.99.1.1

Alternative name(s):
Heme synthase
Protoheme ferro-lyase

Gene names

Name:	hemH
Ordered Locus Names:	Lxx01090

Organism

Leifsonia xyli subsp. xyli (strain CTCB07) [Complete proteome] [HAMAP]

Taxonomic identifier

281090 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Microbacteriaceae › Leifsonia

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323
Catalytic activity	Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323
Pathway	Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323
Subcellular location	Cytoplasm By similarity HAMAP MF_00323.
Sequence similarities	Belongs to the ferrochelatase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferrochelatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 389	389	Ferrochelatase HAMAP MF_00323		PRO_0000175157
Sites
	Metal binding	205	1	Iron By similarity
	Metal binding	303	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6AHF2 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: B86BEB3D80BCECC1	FASTA	389	42,217
	10 20 30 40 50 60 MLGATPAAAG VAEHVTEPVA YDAILLAGFG GPEGQDDVIP FLRNVTRGRG ILDERLEEVA 70 80 90 100 110 120 QHYRHFGGVS PINDQNRALK AALEAELASR GIDLPVLWGN RNWDPYLADA LTEADQRGFT 130 140 150 160 170 180 KLIAVATSAY SSYSSCRQYR EDFARALRET GLEGRIQIDK VRQFFDHPGF VEPFIEGVKN 190 200 210 220 230 240 AVEELRERAP EIHPATGVRI LFSTHSIPST DAGKSGPSGR PDSGEPWGEG GAYAAQHLAV 250 260 270 280 290 300 AEIVSHEATG GTIGWDLVYQ SRSGPPSMPW LEPDINDRIA ELPELGVKAI IIVPLGFVSD 310 320 330 340 350 360 HMEVLWDLDT EAMESSEENG LLAVRVPTPG THAKYVKGLV DLVLERRDGL PVAQRPSLTT 370 380 LGPWYDVCRP GCCENVRLGF KPAVAGLTP

References

[1]

"The genome sequence of the Gram-positive sugarcane pathogen Leifsonia xyli subsp. xyli." Monteiro-Vitorello C.B., Camargo L.E.A., Van Sluys M.A., Kitajima J.P., Truffi D., do Amaral A.M., Harakava R., de Oliveira J.C.F., Wood D., de Oliveira M.C., Miyaki C.Y., Takita M.A., da Silva A.C.R., Furlan L.R., Carraro D.M., Camarotte G., Almeida N.F. Jr., Carrer H. , Coutinho L.L., El-Dorry H.A., Ferro M.I.T., Gagliardi P.R., Giglioti E., Goldman M.H.S., Goldman G.H., Kimura E.T., Ferro E.S., Kuramae E.E., Lemos E.G.M., Lemos M.V.F., Mauro S.M.Z., Machado M.A., Marino C.L., Menck C.F., Nunes L.R., Oliveira R.C., Pereira G.G., Siqueira W., de Souza A.A., Tsai S.M., Zanca A.S., Simpson A.J.G., Brumbley S.M., Setubal J.C. Mol. Plant Microbe Interact. 17:827-836(2004) [PubMed: 15305603] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CTCB07.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016822 Genomic DNA. Translation: AAT88193.1.
RefSeq	YP_061298.1. NC_006087.1.
3D structure databases
ProteinModelPortal	Q6AHF2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2938895.
GenomeReviews	Gene locus Lxx01090 in contig AE016822_GR.
KEGG	lxx:Lxx01090.
NMPDR	fig|281090.3.peg.1220.
PATRIC	22333658. VBILeiXyl11655_0107.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG697135.
OMA	PAVVMAP.
ProtClustDB	PRK00035.
Enzyme and pathway databases
BioCyc	LXYL281090:LXX01090-MONOMER.
Family and domain databases
HAMAP	MF_00323. Ferrochelatase. [Tree]
InterPro	IPR001015. Ferrochelatase. [Graphical view]
KO	K01772.
PANTHER	PTHR11108. Ferrochelatase. 1 hit.
Pfam	PF00762. Ferrochelatase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00109. HemH. 1 hit.
PROSITE	PS00534. FERROCHELATASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEMH_LEIXX

Accession

Primary (citable) accession number: Q6AHF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	September 13, 2004
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program