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Q6AHE8

- GSA_LEIXX

UniProt

Q6AHE8 - GSA_LEIXX

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Leifsonia xyli subsp. xyli (strain CTCB07)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciLXYL281090:GH0X-103-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:Lxx01130
    OrganismiLeifsonia xyli subsp. xyli (strain CTCB07)
    Taxonomic identifieri281090 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia
    ProteomesiUP000001306: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 447447Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000120416Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei272 – 2721N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi281090.Lxx01130.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AHE8.
    SMRiQ6AHE8. Positions 11-428.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiRFMVSGN.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6AHE8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAAIGEAN LAQFGRAQRV IPGGVNSPVR AFRSVGGTPR FMVFANGPYI    50
    VDAEGREYVD LVASWGPAIL GHAHPAVVSA VQEAAARGLS FGASTPAETE 100
    LAEAVIARVP FVEKLRLVST GTEATMTAIR LARGFTGRPL LIKFAGHYHG 150
    HSDSLLAEAG SGLATLSLPG SAGVTEATAA QTLVLPYNDL GAVRAVFEAN 200
    GPDIAAVIAE AAAANMGVVP PDEGFNAALT DLAHEYGALL ILDEVLTGFR 250
    VSEAGFWGLD RGYTPDLVAF GKVIGGGMPL AAVGGRAELM DILAPAGPVY 300
    QAGTLSGNPV AVAAGLATLA HAGEAVYDRL DIVAGTLSAA VSDALTAEGV 350
    AHSVQRAGNL FSFVFGDVAA APRTFAEVQR QEAFRYRAFF HAMLDAGVSL 400
    PPSVFEAWFV TAAHDDAAVG RVLEALPAAA RAAASACPGR PLLFVRR 447
    Length:447
    Mass (Da):45,819
    Last modified:September 13, 2004 - v1
    Checksum:iC080E3476230A568
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016822 Genomic DNA. Translation: AAT88197.1.
    RefSeqiYP_061302.1. NC_006087.1.

    Genome annotation databases

    EnsemblBacteriaiAAT88197; AAT88197; Lxx01130.
    GeneIDi2940479.
    KEGGilxx:Lxx01130.
    PATRICi22333666. VBILeiXyl11655_0111.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016822 Genomic DNA. Translation: AAT88197.1 .
    RefSeqi YP_061302.1. NC_006087.1.

    3D structure databases

    ProteinModelPortali Q6AHE8.
    SMRi Q6AHE8. Positions 11-428.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 281090.Lxx01130.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT88197 ; AAT88197 ; Lxx01130 .
    GeneIDi 2940479.
    KEGGi lxx:Lxx01130.
    PATRICi 22333666. VBILeiXyl11655_0111.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi RFMVSGN.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci LXYL281090:GH0X-103-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CTCB07.

    Entry informationi

    Entry nameiGSA_LEIXX
    AccessioniPrimary (citable) accession number: Q6AHE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 2, 2005
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3