Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6AGS4

- PCKG_LEIXX

UniProt

Q6AGS4 - PCKG_LEIXX

Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Leifsonia xyli subsp. xyli (strain CTCB07)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

    Catalytic activityi

    GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

    Cofactori

    Binds 1 manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei84 – 841SubstrateUniRule annotation
    Binding sitei229 – 2291Substrate; via amide nitrogenUniRule annotation
    Metal bindingi236 – 2361ManganeseUniRule annotation
    Binding sitei236 – 2361SubstrateUniRule annotation
    Metal bindingi256 – 2561Manganese; via tele nitrogenUniRule annotation
    Binding sitei278 – 2781SubstrateUniRule annotation
    Active sitei280 – 2801UniRule annotation
    Metal bindingi303 – 3031ManganeseUniRule annotation
    Binding sitei395 – 3951GTPUniRule annotation
    Binding sitei426 – 4261GTPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi520 – 5234GTPUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Gluconeogenesis

    Keywords - Ligandi

    GTP-binding, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLXYL281090:GH0X-394-MONOMER.
    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
    Short name:
    PEP carboxykinaseUniRule annotation
    Short name:
    PEPCKUniRule annotation
    Gene namesi
    Name:pckGUniRule annotation
    Ordered Locus Names:Lxx04240
    OrganismiLeifsonia xyli subsp. xyli (strain CTCB07)
    Taxonomic identifieri281090 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia
    ProteomesiUP000001306: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 612612Phosphoenolpyruvate carboxykinase [GTP]PRO_0000103606Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi281090.Lxx04240.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AGS4.
    SMRiQ6AGS4. Positions 17-610.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni393 – 3953Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1274.
    HOGENOMiHOG000191700.
    KOiK01596.
    OMAiINTEGLG.
    OrthoDBiEOG6MPWQS.

    Family and domain databases

    Gene3Di3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPiMF_00452. PEPCK_GTP.
    InterProiIPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view]
    PANTHERiPTHR11561. PTHR11561. 1 hit.
    PfamiPF00821. PEPCK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMiSSF68923. SSF68923. 1 hit.
    PROSITEiPS00505. PEPCK_GTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6AGS4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAPPRPTAP PGAAALTGLA ALHAWVDELA ALLQPDGIVW CDGSRGQTDR    50
    LTKQLVAEGK LIRLNPEWRP NSFLSRTDPS DVARVEDRTF ICSLDEADAG 100
    PTNNWREPEG MRAELREAFA GSMRGRTLYV VPFSMGPIGG PLSQLGVQLT 150
    DSAYVAVSMG IMTRVASAVL DLIAAGQPWV PTVHSVGAPL VDEAGVRQED 200
    VAWPCNPVKY IVQFPETREI WSYGSGYGGN AILAKKCFAL RIASVMARDE 250
    GWLAEHMLIV KVTSPEGRVF HFAAAFPSSC GKTNLAMLKP SIPGWTVETV 300
    CDDIAWLRPG PDGRLRAINP EAGFFGVAPG TGELTNKTAV EALWGNTIFT 350
    NVALRDDGDV WWEGLTAEPP AHLIDWEGND WTPASGRPAA HPNSRFTVSA 400
    AQCPVIADEW DVVDGVPIDA ILFGGRRATN VPLVAQARDW KHGVFIGATI 450
    SSEQTAAAEG TVGELRRDPF AMLPFCGYNM ADYWAHWLRM GEKLGADAPA 500
    IFQVNWFRKG DDGRFLWPGF SENARVIEWI ARRVEGSAGA EETAIGRLPL 550
    ADELDLDGLG LPAEDLAALF DIDTERWLAE CALTEQYFAR FGPRVPPALT 600
    AELASLRDKL RA 612
    Length:612
    Mass (Da):66,419
    Last modified:September 13, 2004 - v1
    Checksum:iBB6BD41B5049CE6A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016822 Genomic DNA. Translation: AAT88421.1.
    RefSeqiYP_061526.1. NC_006087.1.

    Genome annotation databases

    EnsemblBacteriaiAAT88421; AAT88421; Lxx04240.
    GeneIDi2939161.
    KEGGilxx:Lxx04240.
    PATRICi22334330. VBILeiXyl11655_0430.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016822 Genomic DNA. Translation: AAT88421.1 .
    RefSeqi YP_061526.1. NC_006087.1.

    3D structure databases

    ProteinModelPortali Q6AGS4.
    SMRi Q6AGS4. Positions 17-610.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 281090.Lxx04240.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT88421 ; AAT88421 ; Lxx04240 .
    GeneIDi 2939161.
    KEGGi lxx:Lxx04240.
    PATRICi 22334330. VBILeiXyl11655_0430.

    Phylogenomic databases

    eggNOGi COG1274.
    HOGENOMi HOG000191700.
    KOi K01596.
    OMAi INTEGLG.
    OrthoDBi EOG6MPWQS.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .
    BioCyci LXYL281090:GH0X-394-MONOMER.

    Family and domain databases

    Gene3Di 3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPi MF_00452. PEPCK_GTP.
    InterProi IPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view ]
    PANTHERi PTHR11561. PTHR11561. 1 hit.
    Pfami PF00821. PEPCK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMi SSF68923. SSF68923. 1 hit.
    PROSITEi PS00505. PEPCK_GTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CTCB07.

    Entry informationi

    Entry nameiPCKG_LEIXX
    AccessioniPrimary (citable) accession number: Q6AGS4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 2, 2005
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3