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Q6AGQ7 (SYW_LEIXX) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:Lxx04450
OrganismLeifsonia xyli subsp. xyli (strain CTCB07) [Complete proteome] [HAMAP]
Taxonomic identifier281090 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 337337Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136641

Regions

Motif13 – 2210"HIGH" region HAMAP-Rule MF_00140
Motif198 – 2025"KMSKS" region HAMAP-Rule MF_00140

Sites

Binding site2011ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AGQ7 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: F5285BA387FD598D

FASTA33736,667
        10         20         30         40         50         60 
MTDSPRLYSG MQPSADSLHL GNYVGALLQW KELQAAHDAF FSVVDLHAIT VAQDPHDLRE 

        70         80         90        100        110        120 
KTRRTAAQYI AAGIDPSVST LYVQSHVPAH AQLAWVLSTI TGYGEAARMT QFKDKSAKQG 

       130        140        150        160        170        180 
AEATSVGLFT YPVLMAADIL LFDADVVPVG DDQRQHVELT RDLAERFNSR FGETFVVPQA 

       190        200        210        220        230        240 
MILKDGARIY DLQSPESKMS KSADSGAGIV WLLDEPDIAR KKIMRAVTDT DGVVSYDRAG 

       250        260        270        280        290        300 
KPGVSNLLSI YSALSGRAIQ QIELDYEGKG YGDFKKGLVE VVVDALGPIR ERTLELLADP 

       310        320        330 
AELDRILAGN AARAGEAAEI TLAKAYEAIG FLQPTRR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016822 Genomic DNA. Translation: AAT88438.1.
RefSeqYP_061543.1. NC_006087.1.

3D structure databases

ProteinModelPortalQ6AGQ7.
SMRQ6AGQ7. Positions 5-332.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING281090.Lxx04450.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT88438; AAT88438; Lxx04450.
GeneID2939368.
KEGGlxx:Lxx04450.
PATRIC22334374. VBILeiXyl11655_0452.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000059940.
KOK01867.
OMAYFIPDMH.
OrthoDBEOG686NJQ.

Enzyme and pathway databases

BioCycLXYL281090:GH0X-413-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYW_LEIXX
AccessionPrimary (citable) accession number: Q6AGQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: September 13, 2004
Last modified: June 11, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries