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Protein

NAD kinase

Gene

nadK

Organism
Leifsonia xyli subsp. xyli (strain CTCB07)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei77Proton acceptorUniRule annotation1
Binding sitei82NADUniRule annotation1
Binding sitei162NADUniRule annotation1
Binding sitei181NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi77 – 78NADUniRule annotation2
Nucleotide bindingi151 – 152NADUniRule annotation2
Nucleotide bindingi192 – 197NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciLXYL281090:G1G06-573-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Lxx05620
OrganismiLeifsonia xyli subsp. xyli (strain CTCB07)
Taxonomic identifieri281090 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrobacteriaceaeLeifsonia
Proteomesi
  • UP000001306 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001206271 – 304NAD kinaseAdd BLAST304

Interactioni

Protein-protein interaction databases

STRINGi281090.Lxx05620

Structurei

3D structure databases

ProteinModelPortaliQ6AGG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227223
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q6AGG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQRYILVV AHTGRRDSLA AGVSVCRQLL AAGVVPVLSE GERRDLLAAE
60 70 80 90 100
PELATVVALG AEVPPAELEL VIVLGGDGTI LRAAELVRGC PAPLLGVNLG
110 120 130 140 150
HVGFLAESER DDLETAVARG LAKDYEVEER MTLSARVKVG EEVVYESWAL
160 170 180 190 200
NEATVEKANR ERVLEVVIEA DGRPMSSFGC DGVVMSTPTG STAYSFSAGG
210 220 230 240 250
PVVWPGVAAL LLVPLSAHAL FSRPLVVDAD SSLAVELLEG AGGEGVLWCD
260 270 280 290 300
GRRAFDLPRG ARVVVRRSPI PVRLARLHPG PFTDRLVRKF TLPVTGWRGP

DGRD
Length:304
Mass (Da):32,238
Last modified:September 13, 2004 - v1
Checksum:i3F00C16BA19E5128
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016822 Genomic DNA Translation: AAT88528.1
RefSeqiWP_011185528.1, NC_006087.1

Genome annotation databases

EnsemblBacteriaiAAT88528; AAT88528; Lxx05620
KEGGilxx:Lxx05620

Similar proteinsi

Entry informationi

Entry nameiNADK_LEIXX
AccessioniPrimary (citable) accession number: Q6AGG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: September 13, 2004
Last modified: April 25, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health