Q6AGF6 (DER_LEIXX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTPase Der

Alternative name(s):
GTP-binding protein EngA

Gene names

Name:	der
Synonyms:	engA
Ordered Locus Names:	Lxx05740

Organism

Leifsonia xyli subsp. xyli (strain CTCB07) [Complete proteome] [HAMAP]

Taxonomic identifier

281090 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Microbacteriaceae › Leifsonia

Protein attributes

Sequence length	481 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	GTPase that plays an essential role in the late steps of ribosome biogenesis By similarity. HAMAP MF_00195
Subunit structure	Associates with the 50S ribosomal subunit By similarity.
Sequence similarities	Belongs to the Era/MnmE GTP-binding protein family. Der subfamily. Contains 2 G (guanine nucleotide-binding) domains. Contains 1 KH-like domain.

Ontologies

Keywords
Biological process	Ribosome biogenesis
Domain	Repeat
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ribosome biogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 481	481	GTPase Der HAMAP MF_00195		PRO_0000179005
Regions
	Domain	58 – 163	106	G 1
	Domain	232 – 340	109	G 2
	Domain	394 – 477	84	KH-like
	Nucleotide binding	53 – 60	8	GTP 1 Potential
	Nucleotide binding	100 – 104	5	GTP 1 Potential
	Nucleotide binding	162 – 165	4	GTP 1 Potential
	Nucleotide binding	227 – 234	8	GTP 2 Potential
	Nucleotide binding	274 – 278	5	GTP 2 Potential
	Nucleotide binding	339 – 342	4	GTP 2 Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6AGF6 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 2F5D362457DCA6EA	FASTA	481	53,098
	10 20 30 40 50 60 MDDDLALQRA VALRSGLDDY ELDDADLDLL EVDGEDADAI AFLPALPVLA IVGRPNVGKS 70 80 90 100 110 120 ALVNRILGRR EAVVEDTPGV TRDRVSYRAE WNGRRFTVVD TGGWEPDARG IDASVAAQAE 130 140 150 160 170 180 VAIDLADAVM FVVDAMVGAT STDEHVVRLL RKSDKPVFLA ANKVDDARQE PSATELWSLG 190 200 210 220 230 240 LGEPHPVSAL HGRGVADLLD KILKALPDVS AVAKQEVGGP RRVAILGRPN VGKSSLLNKA 250 260 270 280 290 300 AGEERVVVNE LAGTTRDPVD EQVELGGRVW RFVDTAGIRR RVHLQQGADF YASLRTSTAL 310 320 330 340 350 360 EKAEVAVVVL DVSQPISEQD VRIIDLVLES GRALVLAFNK WDLLDDERRR YLEREIEQDL 370 380 390 400 410 420 AHVSWAPRVN ISARTGRHLE KLVPALERAL ESWETRIPTG KFNAFLAELT SAHPHPVRGG 430 440 450 460 470 480 KQPRILFGTQ STSRPPTFVV FTTGFLDPGY RRYVIRRLRE VYGFEGTPIV LNMRVREKRK H

References

[1]

"The genome sequence of the Gram-positive sugarcane pathogen Leifsonia xyli subsp. xyli." Monteiro-Vitorello C.B., Camargo L.E.A., Van Sluys M.A., Kitajima J.P., Truffi D., do Amaral A.M., Harakava R., de Oliveira J.C.F., Wood D., de Oliveira M.C., Miyaki C.Y., Takita M.A., da Silva A.C.R., Furlan L.R., Carraro D.M., Camarotte G., Almeida N.F. Jr., Carrer H. , Coutinho L.L., El-Dorry H.A., Ferro M.I.T., Gagliardi P.R., Giglioti E., Goldman M.H.S., Goldman G.H., Kimura E.T., Ferro E.S., Kuramae E.E., Lemos E.G.M., Lemos M.V.F., Mauro S.M.Z., Machado M.A., Marino C.L., Menck C.F., Nunes L.R., Oliveira R.C., Pereira G.G., Siqueira W., de Souza A.A., Tsai S.M., Zanca A.S., Simpson A.J.G., Brumbley S.M., Setubal J.C. Mol. Plant Microbe Interact. 17:827-836(2004) [PubMed: 15305603] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CTCB07.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016822 Genomic DNA. Translation: AAT88539.1.
RefSeq	YP_061644.1. NC_006087.1.
3D structure databases
ProteinModelPortal	Q6AGF6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2938680.
GenomeReviews	Gene locus Lxx05740 in contig AE016822_GR.
KEGG	lxx:Lxx05740.
NMPDR	fig|281090.3.peg.1566.
PATRIC	22334632. VBILeiXyl11655_0581.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG592135.
OMA	QGADFYA.
ProtClustDB	PRK03003.
Enzyme and pathway databases
BioCyc	LXYL281090:LXX05740-MONOMER.
Family and domain databases
HAMAP	MF_00195. GTPase_Der. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR016484. GTP-bd_EngA. IPR006073. GTP_binding_domain. IPR015946. KH_dom-like_a/b. IPR005225. Small_GTP-bd_dom. [Graphical view]
Gene3D	G3DSA:3.30.300.20. KH_prok. 1 hit.
KO	K03977.
PANTHER	PTHR11649:SF5. PTHR11649:SF5. 1 hit.
Pfam	PF01926. MMR_HSR1. 2 hits. [Graphical view]
PIRSF	PIRSF006485. GTP-binding_EngA. 1 hit.
PRINTS	PR00326. GTP1OBG.
SMART	SM00382. AAA. 2 hits. [Graphical view]
TIGRFAMs	TIGR03594. GTPase_EngA. 1 hit. TIGR00231. Small_GTP. 2 hits.
ProtoNet	Search...

Entry information

Entry name

DER_LEIXX

Accession

Primary (citable) accession number: Q6AGF6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 2, 2005
Last sequence update:	September 13, 2004
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program