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Q6AFR0

- TRMB_LEIXX

UniProt

Q6AFR0 - TRMB_LEIXX

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, Lxx08920
Organism
Leifsonia xyli subsp. xyli (strain CTCB07)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei57 – 571S-adenosyl-L-methionine By similarity
Binding sitei82 – 821S-adenosyl-L-methionine By similarity
Binding sitei109 – 1091S-adenosyl-L-methionine By similarity
Active sitei132 – 1321 By similarity
Binding sitei132 – 1321S-adenosyl-L-methionine By similarity
Binding sitei136 – 1361Substrate By similarity
Binding sitei168 – 1681Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciLXYL281090:GH0X-833-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:Lxx08920
OrganismiLeifsonia xyli subsp. xyli (strain CTCB07)
Taxonomic identifieri281090 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia
ProteomesiUP000001306: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_0000171340Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi281090.Lxx08920.

Structurei

3D structure databases

ProteinModelPortaliQ6AFR0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni205 – 2084Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiLHIATDH.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AFR0-1 [UniParc]FASTAAdd to Basket

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MEPAPLVRPR SYVVRGRKTD AQQRAIAEFW PAFGVDFAGG LLDLDALFGR    50
TAPRTVEIGF GNGENLLALA ERHPERDFLG VEVHGAGVGR VFAAMRERGL 100
SNIRVIRHDA VEVFETGLSA GSVAEALLFF PDPWPKARHH RRRLVQPDVV 150
RLLARALAAD GVLRLATDWE PYADHMLAVL DAEPVLVNVA GPGAFIPRPE 200
ARPVTKFERR GEKLGHSIFD LEYRPLP 227
Length:227
Mass (Da):25,120
Last modified:September 13, 2004 - v1
Checksum:i1F661B4CDB39E414
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016822 Genomic DNA. Translation: AAT88785.1.
RefSeqiWP_011185783.1. NC_006087.1.
YP_061890.1. NC_006087.1.

Genome annotation databases

EnsemblBacteriaiAAT88785; AAT88785; Lxx08920.
GeneIDi2940179.
KEGGilxx:Lxx08920.
PATRICi22335338. VBILeiXyl11655_0925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016822 Genomic DNA. Translation: AAT88785.1 .
RefSeqi WP_011185783.1. NC_006087.1.
YP_061890.1. NC_006087.1.

3D structure databases

ProteinModelPortali Q6AFR0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 281090.Lxx08920.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT88785 ; AAT88785 ; Lxx08920 .
GeneIDi 2940179.
KEGGi lxx:Lxx08920.
PATRICi 22335338. VBILeiXyl11655_0925.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi LHIATDH.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci LXYL281090:GH0X-833-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CTCB07.

Entry informationi

Entry nameiTRMB_LEIXX
AccessioniPrimary (citable) accession number: Q6AFR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: September 13, 2004
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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