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Q6AFQ2

- PNP_LEIXX

UniProt

Q6AFQ2 - PNP_LEIXX

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, Lxx09030
Organism
Leifsonia xyli subsp. xyli (strain CTCB07)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi532 – 5321Magnesium By similarity
Metal bindingi538 – 5381Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciLXYL281090:GH0X-843-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:Lxx09030
OrganismiLeifsonia xyli subsp. xyli (strain CTCB07)
Taxonomic identifieri281090 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia
ProteomesiUP000001306: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 761761Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329696Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi281090.Lxx09030.

Structurei

3D structure databases

ProteinModelPortaliQ6AFQ2.
SMRiQ6AFQ2. Positions 5-735.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini598 – 65760KH
Add
BLAST
Domaini669 – 74173S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiTIAGKQD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 1 hit.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AFQ2-1 [UniParc]FASTAAdd to Basket

« Hide

MEGPEITFAE AMLDNGRFGA RTVRFETGRI AQQAQGAVAA YLDEETMLLS    50
ATSASKHPKD NFDFFPLTVD VEERSYAAGK IPGSFFRREG RPSTEAILVC 100
RLIDRPLRPS FVDGLRNEVQ IVVTVLSIAP DEFYDALAIN AASASTQISG 150
LPFSGPIAGV RLALIPGNGA HEDQWVAFPK ASQLEEAVFD LIVVGRVLTN 200
EDGTEGDVAI MMVEAEATEG SWNLIQGGAV KPNEEVVAQG LEAAKPFIRQ 250
LVGAQAALAK QSAKAIADYP VFLPYSQETY DSVAALAYDE LVNVYQIADK 300
VERQNADDAL KERVKAALAE KAQAGALDAE ALTQFSAAYK SVSKVVMRGR 350
VLREGVRIDG RGLTDIRPLD AEVQIIPRVH GSAVFQRGET QILGVTTLNM 400
LKMEQQIDSL SPVTKKRYLH HYNFPPYSTG ETGRVGSPKR REIGHGFLAE 450
RALVPVLPSR EEFPYAIRQV SEALSSNGST SMGSVCASTL SLLNAGVPLR 500
APVAGIAMGL ISDVIDGETR YAALTDILGA EDALGDMDFK VAGTSEFVTA 550
IQLDTKLDGI PSSVLASALK QAKDARTTIL SVLDAAIDAP DEMAPTAPRV 600
ISVQIPVDKI GELIGPKGKT INAIQDETGA DISIDEDGTV YIGAVDGPSA 650
EAARAQVNVI ANPTNPEVGE QFLGTVVKNA AFGAFVSLLP GKDGLLHISE 700
VRKLAGGKRV ESVDDVLSIG QKILVEITKI DDRGKLSLAP VLADEAETHG 750
HDAASEGPTE G 761
Length:761
Mass (Da):80,920
Last modified:September 13, 2004 - v1
Checksum:i927E5E10495426B8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016822 Genomic DNA. Translation: AAT88793.1.
RefSeqiYP_061898.1. NC_006087.1.

Genome annotation databases

EnsemblBacteriaiAAT88793; AAT88793; Lxx09030.
GeneIDi2939599.
KEGGilxx:Lxx09030.
PATRICi22335362. VBILeiXyl11655_0937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016822 Genomic DNA. Translation: AAT88793.1 .
RefSeqi YP_061898.1. NC_006087.1.

3D structure databases

ProteinModelPortali Q6AFQ2.
SMRi Q6AFQ2. Positions 5-735.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 281090.Lxx09030.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT88793 ; AAT88793 ; Lxx09030 .
GeneIDi 2939599.
KEGGi lxx:Lxx09030.
PATRICi 22335362. VBILeiXyl11655_0937.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi TIAGKQD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci LXYL281090:GH0X-843-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 1 hit.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CTCB07.

Entry informationi

Entry nameiPNP_LEIXX
AccessioniPrimary (citable) accession number: Q6AFQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 13, 2004
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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