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Q6AFB6 (RUVC_LEIXX) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Crossover junction endodeoxyribonuclease RuvC

EC=3.1.22.4
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene names
Name:ruvC
Ordered Locus Names:Lxx10760
OrganismLeifsonia xyli subsp. xyli (strain CTCB07) [Complete proteome] [HAMAP]
Taxonomic identifier281090 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity. HAMAP-Rule MF_00034

Catalytic activity

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). HAMAP-Rule MF_00034

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_00034

Sequence similarities

Belongs to the RuvC family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 208208Crossover junction endodeoxyribonuclease RuvC HAMAP-Rule MF_00034
PRO_0000183107

Sites

Metal binding91Magnesium By similarity
Metal binding701Magnesium By similarity
Metal binding1431Magnesium By similarity
Metal binding1461Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AFB6 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 4F9039BF2B0BCFFC

FASTA20821,349
        10         20         30         40         50         60 
MTIRVLGIDP GLTRCGVGVV DVRRDRRATL VEVTVIRTPA EMPLEQRLLA VGDGIAALLD 

        70         80         90        100        110        120 
RYSPAAVAIE RVFAQHNLRT VIGVAQVSGV ALHTAAQRGL PVALHTPSEV KAAITGYGSA 

       130        140        150        160        170        180 
DKKQVQAMVA RVLGLPEAPK PADAADALAI AICHAWRGGL AALSTSGAVG AAGPAAVPGA 

       190        200 
ALTPAQAAWR AAERSTARTS SAPRRLAR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016822 Genomic DNA. Translation: AAT88929.1.
RefSeqYP_062034.1. NC_006087.1.

3D structure databases

ProteinModelPortalQ6AFB6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING281090.Lxx10760.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT88929; AAT88929; Lxx10760.
GeneID2938347.
KEGGlxx:Lxx10760.
PATRIC22335720. VBILeiXyl11655_1110.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0817.
HOGENOMHOG000012182.
KOK01159.
OMACHAWRGG.
OrthoDBEOG6RG044.

Enzyme and pathway databases

BioCycLXYL281090:GH0X-1006-MONOMER.

Family and domain databases

Gene3D3.30.420.10. 1 hit.
HAMAPMF_00034. RuvC.
InterProIPR012337. RNaseH-like_dom.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSPR00696. RSOLVASERUVC.
SUPFAMSSF53098. SSF53098. 1 hit.
TIGRFAMsTIGR00228. ruvC. 1 hit.
PROSITEPS01321. RUVC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRUVC_LEIXX
AccessionPrimary (citable) accession number: Q6AFB6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: September 13, 2004
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families