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Q6AF82 (KGUA_LEIXX) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanylate kinase

EC=2.7.4.8
Alternative name(s):
GMP kinase
Gene names
Name:gmk
Ordered Locus Names:Lxx11120
OrganismLeifsonia xyli subsp. xyli (strain CTCB07) [Complete proteome] [HAMAP]
Taxonomic identifier281090 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP-Rule MF_00328

Catalytic activity

ATP + GMP = ADP + GDP. HAMAP-Rule MF_00328

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00328.

Sequence similarities

Belongs to the guanylate kinase family.

Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpurine nucleotide metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

guanylate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 254254Guanylate kinase HAMAP-Rule MF_00328
PRO_0000266343

Regions

Domain64 – 243180Guanylate kinase-like
Nucleotide binding71 – 788ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AF82 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: DA832AE93BF3F6C1

FASTA25428,385
        10         20         30         40         50         60 
MEGRIRVTEF LLSVPAIGTT KTQDALRRLG IAPSKRLGGL GRHQRLRLRV FLIEREERPV 

        70         80         90        100        110        120 
RRRKHLVVLA GPTAVGKGTV SAYIRENYPE VLLSVSATTR SPRPGEVDGV NYYFVDDAAF 

       130        140        150        160        170        180 
DRMIAAGDLL EHATVHNAYR YGTPRAPIEK ALDDGRSVLL EIDLQGARQV RASMPEARLI 

       190        200        210        220        230        240 
FLLPPTWEEL VRRLTGRGTE DAAEQQRRLE TAKVELAAQN EFDHRVVNHT VADAAREVVD 

       250 
LMMVRPAPVR PSTA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016822 Genomic DNA. Translation: AAT88963.1.
RefSeqYP_062068.1. NC_006087.1.

3D structure databases

ProteinModelPortalQ6AF82.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING281090.Lxx11120.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT88963; AAT88963; Lxx11120.
GeneID2939739.
KEGGlxx:Lxx11120.
PATRIC22335798. VBILeiXyl11655_1149.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0194.
HOGENOMHOG000037640.
KOK00942.
OMAQGGFLEW.
OrthoDBEOG6CP410.

Enzyme and pathway databases

BioCycLXYL281090:GH0X-1041-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_00328. Guanylate_kinase.
InterProIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR03263. guanyl_kin. 1 hit.
PROSITEPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKGUA_LEIXX
AccessionPrimary (citable) accession number: Q6AF82
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: September 13, 2004
Last modified: June 11, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families