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Q6AF44 (PGK_LEIXX) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:Lxx11530
OrganismLeifsonia xyli subsp. xyli (strain CTCB07) [Complete proteome] [HAMAP]
Taxonomic identifier281090 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 403403Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000145957

Regions

Nucleotide binding359 – 3624ATP By similarity
Region22 – 243Substrate binding By similarity
Region60 – 634Substrate binding By similarity

Sites

Binding site371Substrate By similarity
Binding site1191Substrate By similarity
Binding site1561Substrate By similarity
Binding site2061ATP By similarity
Binding site3021ATP; via carbonyl oxygen By similarity
Binding site3331ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AF44 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 3DCC1BF68C892355

FASTA40341,900
        10         20         30         40         50         60 
MALRTLDSLG SLAGKRVVVR CDLNVPLKDG KITDDGRVRA SIPTLHALIA QGAKVAIVSH 

        70         80         90        100        110        120 
LGRPEGAPDA QYSLAPVAQR LSELLGKPVT FASDTVGAGA AEAVSGLEDG DVALLENLRF 

       130        140        150        160        170        180 
NPGETSKDEG EREAFAAELA AFGDAFVSDG FGVVHRKQAS VYELAKALPS AAGALIATEL 

       190        200        210        220        230        240 
DVLDRLTENP ERPYTVLLGG SKVSDKLGVI GHLLPRVDSL LIGGGMLFTF LAALGHRVGS 

       250        260        270        280        290        300 
SLLEADQIGT VKGYLEQAKQ LGVEIVLPRD VVVASRFGVD AEHLVRPVDR IEDTGWGTSG 

       310        320        330        340        350        360 
LGLDIGPETA EVFSERIRAA RTVFWNGPMG VFELAPFAAG TKAVAQALTE VDGLGVVGGG 

       370        380        390        400 
DSAAAVHALG FSDDQFGHIS TGGGASLEFL EGKRLPGLEV LGW 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016822 Genomic DNA. Translation: AAT89001.1.
RefSeqYP_062106.1. NC_006087.1.

3D structure databases

ProteinModelPortalQ6AF44.
SMRQ6AF44. Positions 4-402.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING281090.Lxx11530.

Proteomic databases

PRIDEQ6AF44.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT89001; AAT89001; Lxx11530.
GeneID2940304.
KEGGlxx:Lxx11530.
PATRIC22335884. VBILeiXyl11655_1191.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227107.
KOK00927.
OMAHASVYDI.
OrthoDBEOG64N9Z0.

Enzyme and pathway databases

BioCycLXYL281090:GH0X-1081-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_LEIXX
AccessionPrimary (citable) accession number: Q6AF44
Entry history
Integrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: September 13, 2004
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways