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Q6AEW2

- SYL_LEIXX

UniProt

Q6AEW2 - SYL_LEIXX

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Leifsonia xyli subsp. xyli (strain CTCB07)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei631 – 6311ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLXYL281090:GH0X-1166-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Lxx12370
    OrganismiLeifsonia xyli subsp. xyli (strain CTCB07)
    Taxonomic identifieri281090 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia
    ProteomesiUP000001306: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 866866Leucine--tRNA ligasePRO_0000152034Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi281090.Lxx12370.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6AEW2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi59 – 6911"HIGH" regionAdd
    BLAST
    Motifi628 – 6325"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiDEIEPRW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6AEW2-1 [UniParc]FASTAAdd to Basket

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    MAHQHDTGTA AAAAGKTAIH YDFAQIQAKW LPVWEKLKPF ATDDPEDNRP    50
    RKYVLDMFPY PSGDLHMGHA EAYALGDVIA RYWRHQGFSV LHPIGWDAFG 100
    LPAENAAIKR GLDPRGWTYD NIAQQKASMR RYAPSFDWDR VLQTCDPSYY 150
    KWNQWLFLKL YEKGLAYRKA SQVNWCPFDQ TVLANEQVVN GRCERCDNLV 200
    TKKKLTQWYF RITDYADRLL DDLNQLEGAW PAKVILMQRN WIGRSTGADV 250
    QFAIEGREEP VAVYTTRPDT LYGVTFMVVA PDSELAAELA EDARPEVKQR 300
    FEEYLAAVRG TTEMDRLSTE REKTGVFLER HAVNPLTGES IPIWAADYVL 350
    SDYGHGAIMA VPAHDQRDLD FARAFDLPVR VVVDTTQPAT GAVPVIKTDP 400
    QTGEPLLPES APLESPAETG QALTGEGRLI NSGPFDGLSK SNAIRRVTEA 450
    LQGSGLGAPA KNFRLRDWLI SRQRYWGTPI PIVHCEACGE VPVPESELPV 500
    LLPPAEGLDL QPKGRSPLGA ASDWVNVSCF SCGGPAQRDT DTMDTFVDSS 550
    WYFLRFLNPN DDTRAFDPRE AEKWAPVDQY VGGVTHAILH LLYSRFITKV 600
    LFDQGFVSFT EPFTVLLNQG MVLMDGSAMS KSRGNLVKLS DQLDAHGVDA 650
    VRLTMSFAGP PEDDIDWADV SPSGSAKFLA RAWRVAHDVT SAPDVVWKSG 700
    DPALRRVTHR FLADTPGLVE AFKFNVVVAR LMELVNATRK TIDSGAGPAD 750
    RAVREAAEVT TMALNLFAPY TAEDMWARLG YEPSVSLVPW RKPDPTLLIE 800
    EAVTAIVQVD GKVRDRVEVS PKISVDELEA LARSSEAVLR SVGDREIVTV 850
    IVRAPKLVNI ATRSRS 866
    Length:866
    Mass (Da):96,258
    Last modified:September 13, 2004 - v1
    Checksum:iA550EF6D38634B63
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016822 Genomic DNA. Translation: AAT89083.1.
    RefSeqiWP_011186079.1. NC_006087.1.
    YP_062188.1. NC_006087.1.

    Genome annotation databases

    EnsemblBacteriaiAAT89083; AAT89083; Lxx12370.
    GeneIDi2939631.
    KEGGilxx:Lxx12370.
    PATRICi22336067. VBILeiXyl11655_1282.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016822 Genomic DNA. Translation: AAT89083.1 .
    RefSeqi WP_011186079.1. NC_006087.1.
    YP_062188.1. NC_006087.1.

    3D structure databases

    ProteinModelPortali Q6AEW2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 281090.Lxx12370.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT89083 ; AAT89083 ; Lxx12370 .
    GeneIDi 2939631.
    KEGGi lxx:Lxx12370.
    PATRICi 22336067. VBILeiXyl11655_1282.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi DEIEPRW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci LXYL281090:GH0X-1166-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CTCB07.

    Entry informationi

    Entry nameiSYL_LEIXX
    AccessioniPrimary (citable) accession number: Q6AEW2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 2, 2005
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3