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Q6AEW2 (SYL_LEIXX) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:Lxx12370
OrganismLeifsonia xyli subsp. xyli (strain CTCB07) [Complete proteome] [HAMAP]
Taxonomic identifier281090 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia

Protein attributes

Sequence length866 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 866866Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000152034

Regions

Motif59 – 6911"HIGH" region HAMAP-Rule MF_00049
Motif628 – 6325"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6311ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6AEW2 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: A550EF6D38634B63

FASTA86696,258
        10         20         30         40         50         60 
MAHQHDTGTA AAAAGKTAIH YDFAQIQAKW LPVWEKLKPF ATDDPEDNRP RKYVLDMFPY 

        70         80         90        100        110        120 
PSGDLHMGHA EAYALGDVIA RYWRHQGFSV LHPIGWDAFG LPAENAAIKR GLDPRGWTYD 

       130        140        150        160        170        180 
NIAQQKASMR RYAPSFDWDR VLQTCDPSYY KWNQWLFLKL YEKGLAYRKA SQVNWCPFDQ 

       190        200        210        220        230        240 
TVLANEQVVN GRCERCDNLV TKKKLTQWYF RITDYADRLL DDLNQLEGAW PAKVILMQRN 

       250        260        270        280        290        300 
WIGRSTGADV QFAIEGREEP VAVYTTRPDT LYGVTFMVVA PDSELAAELA EDARPEVKQR 

       310        320        330        340        350        360 
FEEYLAAVRG TTEMDRLSTE REKTGVFLER HAVNPLTGES IPIWAADYVL SDYGHGAIMA 

       370        380        390        400        410        420 
VPAHDQRDLD FARAFDLPVR VVVDTTQPAT GAVPVIKTDP QTGEPLLPES APLESPAETG 

       430        440        450        460        470        480 
QALTGEGRLI NSGPFDGLSK SNAIRRVTEA LQGSGLGAPA KNFRLRDWLI SRQRYWGTPI 

       490        500        510        520        530        540 
PIVHCEACGE VPVPESELPV LLPPAEGLDL QPKGRSPLGA ASDWVNVSCF SCGGPAQRDT 

       550        560        570        580        590        600 
DTMDTFVDSS WYFLRFLNPN DDTRAFDPRE AEKWAPVDQY VGGVTHAILH LLYSRFITKV 

       610        620        630        640        650        660 
LFDQGFVSFT EPFTVLLNQG MVLMDGSAMS KSRGNLVKLS DQLDAHGVDA VRLTMSFAGP 

       670        680        690        700        710        720 
PEDDIDWADV SPSGSAKFLA RAWRVAHDVT SAPDVVWKSG DPALRRVTHR FLADTPGLVE 

       730        740        750        760        770        780 
AFKFNVVVAR LMELVNATRK TIDSGAGPAD RAVREAAEVT TMALNLFAPY TAEDMWARLG 

       790        800        810        820        830        840 
YEPSVSLVPW RKPDPTLLIE EAVTAIVQVD GKVRDRVEVS PKISVDELEA LARSSEAVLR 

       850        860 
SVGDREIVTV IVRAPKLVNI ATRSRS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016822 Genomic DNA. Translation: AAT89083.1.
RefSeqYP_062188.1. NC_006087.1.

3D structure databases

ProteinModelPortalQ6AEW2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING281090.Lxx12370.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT89083; AAT89083; Lxx12370.
GeneID2939631.
KEGGlxx:Lxx12370.
PATRIC22336067. VBILeiXyl11655_1282.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMALHMGHAE.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycLXYL281090:GH0X-1166-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_LEIXX
AccessionPrimary (citable) accession number: Q6AEW2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: September 13, 2004
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries