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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Leifsonia xyli subsp. xyli (strain CTCB07)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei631 – 6311ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLXYL281090:GH0X-1166-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Lxx12370
OrganismiLeifsonia xyli subsp. xyli (strain CTCB07)
Taxonomic identifieri281090 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia
ProteomesiUP000001306: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 866866Leucine--tRNA ligasePRO_0000152034Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi281090.Lxx12370.

Structurei

3D structure databases

ProteinModelPortaliQ6AEW2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi59 – 6911"HIGH" regionAdd
BLAST
Motifi628 – 6325"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiLHMGHAE.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AEW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHQHDTGTA AAAAGKTAIH YDFAQIQAKW LPVWEKLKPF ATDDPEDNRP
60 70 80 90 100
RKYVLDMFPY PSGDLHMGHA EAYALGDVIA RYWRHQGFSV LHPIGWDAFG
110 120 130 140 150
LPAENAAIKR GLDPRGWTYD NIAQQKASMR RYAPSFDWDR VLQTCDPSYY
160 170 180 190 200
KWNQWLFLKL YEKGLAYRKA SQVNWCPFDQ TVLANEQVVN GRCERCDNLV
210 220 230 240 250
TKKKLTQWYF RITDYADRLL DDLNQLEGAW PAKVILMQRN WIGRSTGADV
260 270 280 290 300
QFAIEGREEP VAVYTTRPDT LYGVTFMVVA PDSELAAELA EDARPEVKQR
310 320 330 340 350
FEEYLAAVRG TTEMDRLSTE REKTGVFLER HAVNPLTGES IPIWAADYVL
360 370 380 390 400
SDYGHGAIMA VPAHDQRDLD FARAFDLPVR VVVDTTQPAT GAVPVIKTDP
410 420 430 440 450
QTGEPLLPES APLESPAETG QALTGEGRLI NSGPFDGLSK SNAIRRVTEA
460 470 480 490 500
LQGSGLGAPA KNFRLRDWLI SRQRYWGTPI PIVHCEACGE VPVPESELPV
510 520 530 540 550
LLPPAEGLDL QPKGRSPLGA ASDWVNVSCF SCGGPAQRDT DTMDTFVDSS
560 570 580 590 600
WYFLRFLNPN DDTRAFDPRE AEKWAPVDQY VGGVTHAILH LLYSRFITKV
610 620 630 640 650
LFDQGFVSFT EPFTVLLNQG MVLMDGSAMS KSRGNLVKLS DQLDAHGVDA
660 670 680 690 700
VRLTMSFAGP PEDDIDWADV SPSGSAKFLA RAWRVAHDVT SAPDVVWKSG
710 720 730 740 750
DPALRRVTHR FLADTPGLVE AFKFNVVVAR LMELVNATRK TIDSGAGPAD
760 770 780 790 800
RAVREAAEVT TMALNLFAPY TAEDMWARLG YEPSVSLVPW RKPDPTLLIE
810 820 830 840 850
EAVTAIVQVD GKVRDRVEVS PKISVDELEA LARSSEAVLR SVGDREIVTV
860
IVRAPKLVNI ATRSRS
Length:866
Mass (Da):96,258
Last modified:September 13, 2004 - v1
Checksum:iA550EF6D38634B63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016822 Genomic DNA. Translation: AAT89083.1.
RefSeqiWP_011186079.1. NC_006087.1.
YP_062188.1. NC_006087.1.

Genome annotation databases

EnsemblBacteriaiAAT89083; AAT89083; Lxx12370.
GeneIDi2939631.
KEGGilxx:Lxx12370.
PATRICi22336067. VBILeiXyl11655_1282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016822 Genomic DNA. Translation: AAT89083.1.
RefSeqiWP_011186079.1. NC_006087.1.
YP_062188.1. NC_006087.1.

3D structure databases

ProteinModelPortaliQ6AEW2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi281090.Lxx12370.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT89083; AAT89083; Lxx12370.
GeneIDi2939631.
KEGGilxx:Lxx12370.
PATRICi22336067. VBILeiXyl11655_1282.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiLHMGHAE.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciLXYL281090:GH0X-1166-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CTCB07.

Entry informationi

Entry nameiSYL_LEIXX
AccessioniPrimary (citable) accession number: Q6AEW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: September 13, 2004
Last modified: March 4, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.