Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Leifsonia xyli subsp. xyli (strain CTCB07)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei631ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLXYL281090:G1G06-1270-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Lxx12370
OrganismiLeifsonia xyli subsp. xyli (strain CTCB07)
Taxonomic identifieri281090 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrobacteriaceaeLeifsonia
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001520341 – 866Leucine--tRNA ligaseAdd BLAST866

Proteomic databases

PRIDEiQ6AEW2

Interactioni

Protein-protein interaction databases

STRINGi281090.Lxx12370

Structurei

3D structure databases

ProteinModelPortaliQ6AEW2
SMRiQ6AEW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi59 – 69"HIGH" regionAdd BLAST11
Motifi628 – 632"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiDIDWADV
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q6AEW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHQHDTGTA AAAAGKTAIH YDFAQIQAKW LPVWEKLKPF ATDDPEDNRP
60 70 80 90 100
RKYVLDMFPY PSGDLHMGHA EAYALGDVIA RYWRHQGFSV LHPIGWDAFG
110 120 130 140 150
LPAENAAIKR GLDPRGWTYD NIAQQKASMR RYAPSFDWDR VLQTCDPSYY
160 170 180 190 200
KWNQWLFLKL YEKGLAYRKA SQVNWCPFDQ TVLANEQVVN GRCERCDNLV
210 220 230 240 250
TKKKLTQWYF RITDYADRLL DDLNQLEGAW PAKVILMQRN WIGRSTGADV
260 270 280 290 300
QFAIEGREEP VAVYTTRPDT LYGVTFMVVA PDSELAAELA EDARPEVKQR
310 320 330 340 350
FEEYLAAVRG TTEMDRLSTE REKTGVFLER HAVNPLTGES IPIWAADYVL
360 370 380 390 400
SDYGHGAIMA VPAHDQRDLD FARAFDLPVR VVVDTTQPAT GAVPVIKTDP
410 420 430 440 450
QTGEPLLPES APLESPAETG QALTGEGRLI NSGPFDGLSK SNAIRRVTEA
460 470 480 490 500
LQGSGLGAPA KNFRLRDWLI SRQRYWGTPI PIVHCEACGE VPVPESELPV
510 520 530 540 550
LLPPAEGLDL QPKGRSPLGA ASDWVNVSCF SCGGPAQRDT DTMDTFVDSS
560 570 580 590 600
WYFLRFLNPN DDTRAFDPRE AEKWAPVDQY VGGVTHAILH LLYSRFITKV
610 620 630 640 650
LFDQGFVSFT EPFTVLLNQG MVLMDGSAMS KSRGNLVKLS DQLDAHGVDA
660 670 680 690 700
VRLTMSFAGP PEDDIDWADV SPSGSAKFLA RAWRVAHDVT SAPDVVWKSG
710 720 730 740 750
DPALRRVTHR FLADTPGLVE AFKFNVVVAR LMELVNATRK TIDSGAGPAD
760 770 780 790 800
RAVREAAEVT TMALNLFAPY TAEDMWARLG YEPSVSLVPW RKPDPTLLIE
810 820 830 840 850
EAVTAIVQVD GKVRDRVEVS PKISVDELEA LARSSEAVLR SVGDREIVTV
860
IVRAPKLVNI ATRSRS
Length:866
Mass (Da):96,258
Last modified:September 13, 2004 - v1
Checksum:iA550EF6D38634B63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016822 Genomic DNA Translation: AAT89083.1
RefSeqiWP_011186079.1, NC_006087.1

Genome annotation databases

EnsemblBacteriaiAAT89083; AAT89083; Lxx12370
KEGGilxx:Lxx12370

Similar proteinsi

Entry informationi

Entry nameiSYL_LEIXX
AccessioniPrimary (citable) accession number: Q6AEW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health