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Q6AEW2

- SYL_LEIXX

UniProt

Q6AEW2 - SYL_LEIXX

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Protein
Leucine--tRNA ligase
Gene
leuS, Lxx12370
Organism
Leifsonia xyli subsp. xyli (strain CTCB07)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei631 – 6311ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLXYL281090:GH0X-1166-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Lxx12370
OrganismiLeifsonia xyli subsp. xyli (strain CTCB07)
Taxonomic identifieri281090 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeLeifsonia
ProteomesiUP000001306: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 866866Leucine--tRNA ligaseUniRule annotation
PRO_0000152034Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi281090.Lxx12370.

Structurei

3D structure databases

ProteinModelPortaliQ6AEW2.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi59 – 6911"HIGH" regionUniRule annotation
Add
BLAST
Motifi628 – 6325"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiDEIEPRW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6AEW2-1 [UniParc]FASTAAdd to Basket

« Hide

MAHQHDTGTA AAAAGKTAIH YDFAQIQAKW LPVWEKLKPF ATDDPEDNRP    50
RKYVLDMFPY PSGDLHMGHA EAYALGDVIA RYWRHQGFSV LHPIGWDAFG 100
LPAENAAIKR GLDPRGWTYD NIAQQKASMR RYAPSFDWDR VLQTCDPSYY 150
KWNQWLFLKL YEKGLAYRKA SQVNWCPFDQ TVLANEQVVN GRCERCDNLV 200
TKKKLTQWYF RITDYADRLL DDLNQLEGAW PAKVILMQRN WIGRSTGADV 250
QFAIEGREEP VAVYTTRPDT LYGVTFMVVA PDSELAAELA EDARPEVKQR 300
FEEYLAAVRG TTEMDRLSTE REKTGVFLER HAVNPLTGES IPIWAADYVL 350
SDYGHGAIMA VPAHDQRDLD FARAFDLPVR VVVDTTQPAT GAVPVIKTDP 400
QTGEPLLPES APLESPAETG QALTGEGRLI NSGPFDGLSK SNAIRRVTEA 450
LQGSGLGAPA KNFRLRDWLI SRQRYWGTPI PIVHCEACGE VPVPESELPV 500
LLPPAEGLDL QPKGRSPLGA ASDWVNVSCF SCGGPAQRDT DTMDTFVDSS 550
WYFLRFLNPN DDTRAFDPRE AEKWAPVDQY VGGVTHAILH LLYSRFITKV 600
LFDQGFVSFT EPFTVLLNQG MVLMDGSAMS KSRGNLVKLS DQLDAHGVDA 650
VRLTMSFAGP PEDDIDWADV SPSGSAKFLA RAWRVAHDVT SAPDVVWKSG 700
DPALRRVTHR FLADTPGLVE AFKFNVVVAR LMELVNATRK TIDSGAGPAD 750
RAVREAAEVT TMALNLFAPY TAEDMWARLG YEPSVSLVPW RKPDPTLLIE 800
EAVTAIVQVD GKVRDRVEVS PKISVDELEA LARSSEAVLR SVGDREIVTV 850
IVRAPKLVNI ATRSRS 866
Length:866
Mass (Da):96,258
Last modified:September 13, 2004 - v1
Checksum:iA550EF6D38634B63
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016822 Genomic DNA. Translation: AAT89083.1.
RefSeqiWP_011186079.1. NC_006087.1.
YP_062188.1. NC_006087.1.

Genome annotation databases

EnsemblBacteriaiAAT89083; AAT89083; Lxx12370.
GeneIDi2939631.
KEGGilxx:Lxx12370.
PATRICi22336067. VBILeiXyl11655_1282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016822 Genomic DNA. Translation: AAT89083.1 .
RefSeqi WP_011186079.1. NC_006087.1.
YP_062188.1. NC_006087.1.

3D structure databases

ProteinModelPortali Q6AEW2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 281090.Lxx12370.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT89083 ; AAT89083 ; Lxx12370 .
GeneIDi 2939631.
KEGGi lxx:Lxx12370.
PATRICi 22336067. VBILeiXyl11655_1282.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi DEIEPRW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci LXYL281090:GH0X-1166-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CTCB07.

Entry informationi

Entry nameiSYL_LEIXX
AccessioniPrimary (citable) accession number: Q6AEW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: September 13, 2004
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi