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Q6AET5 (Q6AET5_LEIXX) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyruvate dehydrogenase E1 component PIRNR PIRNR000156
EC=1.2.4.1 PIRNR PIRNR000156
Gene names
Name:aceE EMBL AAT89110.1
Ordered Locus Names:Lxx12700
OrganismLeifsonia xyli subsp. xyli (strain CTCB07) [Complete proteome] [HAMAP]
Taxonomic identifier281090 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Microbacteriaceae › Leifsonia

Protein attributes

Sequence length908 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. PIRNR PIRNR000156

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2. PIRNR PIRNR000156

Cofactor

Thiamine pyrophosphate By similarity. PIRNR PIRNR000156

Sequences

Sequence LengthMass (Da)Tools
Q6AET5 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 23512C69538159D9

FASTA908100,558
        10         20         30         40         50         60 
MTVNDQDPYS MSNIDSDPEE TAEWQESLDA LVAAHGHERA REIMLSLLKR SKELHLGVPM 

        70         80         90        100        110        120 
VPTTDYINTI SPENEPDFPG DEDIERRYRA WIRWNAAILV HRAQRPGIAV GGHISTYASS 

       130        140        150        160        170        180 
AALYEVGFNH FFRGQDHPGG GDQIFVQGHA SPGTYARAFL EGRLSADQLD GFRQEKSHAG 

       190        200        210        220        230        240 
GGLSSYPHPR LMPEFWQFPT VSMGLGPINA IYQAQLNKYL TNRGIKDASD QHVWAFLGDG 

       250        260        270        280        290        300 
EVDEVESRGQ LQVAANEQLD NLTFVINANL QRLDGPVRGN GKIIQELESY FRGAGWNVIK 

       310        320        330        340        350        360 
VIWGREWDDL LARDADGALV NLMNQTPDGD YQTYKTENGA YVRENFFGRD PRTLELVKDF 

       370        380        390        400        410        420 
SDDEVWNLKR GGHDYRKVYA AFKAAVEHKG QPTVIIAKTI KGYGLGPSFE GRNATHQMKK 

       430        440        450        460        470        480 
MTLDNLKTFR DAMRIPVTDA QLEENPYLPP YYNPGPQDEA IQYLHERRRA LGGYLPERRA 

       490        500        510        520        530        540 
TYTQVSLPDD SAYAIAKKGS GTQEIATTMA FVRLLKDLLR AKDFGHRIVP IIPDEARTFG 

       550        560        570        580        590        600 
MDAFFPNAKI YNPNGQHYTS VDRELLLAYK ESPQGQIIHV GINEAGALAA FTNVGTSYAT 

       610        620        630        640        650        660 
QGEPLIPVYV FYSMFGFQRT GDAIWAAGDQ MARGFMIGAT AGRTTLTGEG LQHADGHSLV 

       670        680        690        700        710        720 
LSNTNPAVVS YDPAYGYEIG HIVRSGLERM YGKSHPEPNV MYYLTVYNEP IVQPAEPENV 

       730        740        750        760        770        780 
DVDGIVRGIH KLSEGEGGGP KAQLLASGVS VPWALEAQHL LQQDWGVSAD VWSVTSWGEL 

       790        800        810        820        830        840 
RRDGLKAEEH NFLHPQQEKQ VPYVTRKLEG AEGPFVAVTD YMHAVPDKIR PFVPGEYATL 

       850        860        870        880        890        900 
GADGFGFSDT RAAARRFFKI DGPSLVVRTL ELLAAQGKVD PNAPAWAIEK YLLHDVNAGT 


TGTAGGDA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016822 Genomic DNA. Translation: AAT89110.1.
RefSeqYP_062215.1. NC_006087.1.

3D structure databases

ProteinModelPortalQ6AET5.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2938684.
GenomeReviewsGene locus Lxx12700 in contig AE016822_GR.
KEGGlxx:Lxx12700.
NMPDRfig|281090.3.peg.732.
PATRIC22336135. VBILeiXyl11655_1315.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG289271.
OMAFRQEKSH.
ProtClustDBPRK09405.

Family and domain databases

InterProIPR004660. 2-oxoA_DH_E1.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK00163.
PANTHERPTHR11624:SF37. PTHR11624:SF37. 1 hit.
PfamPF00456. Transketolase_N. 2 hits.
[Graphical view]
PIRSFPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00759. AceE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ6AET5_LEIXX
AccessionPrimary (citable) accession number: Q6AET5
Entry history
Integrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info